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Ionized Water An Alternative Therapy for Cellular Stress

Ionized Water An Alternative Therapy for Cellular Stress. Tim McKnight, MD, MS, FAAFP May 15, 2011 Palm Desert, California. My background. Fit For Life. Healthy Community Outreach Program Rural Health Services Outreach Grant Department of Health & Human Services.

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Ionized Water An Alternative Therapy for Cellular Stress

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  1. Ionized WaterAn Alternative Therapy for Cellular Stress Tim McKnight, MD, MS, FAAFP May 15, 2011 Palm Desert, California

  2. My background

  3. Fit For Life Healthy Community Outreach Program Rural Health Services Outreach Grant Department of Health & Human Services

  4. The American Wellness Crisis Obesity Heart Disease Hypertension Elevated Lipids Cancer Diabetes Acid Reflux Gallstones Arthritis Sleep Apnea Substance Abuse Depression Anxiety ADHD Back Pain Irritable Bowel Syndrome Autoimmune disease Rheumatoid arthritis Inflammatory Bowel Thyroiditis

  5. Leading Causes of Death Anderson RN. “Deaths: leading causes for 2000.” National Vital Statistics Reports 50(16), 2002 Heart Disease…………………710,760 Cancer…………………………553,091 Medical Care………………….225,400 Stroke………………………….167,661 COPD………………………….122,009 Accidents……………………….97,900 Diabetes………………………...69,301 Influenza/Pneumonia………….65,313 Alzheimer’s Disease…………..49,558

  6. Death by Health Care1 1- Starfield B. “Is U.S. health really the best in the world?” JAMA 284 (2000): 483-85 2- Phillips D, et al “Increase in U.S. medication-error death between 1983-1993.” Lancet 351 (1998): 643-644 3- Leape L. “Unnecessary surgery.” Ann. Rev. Publ. Health 13 (1992): 363-383 4- lazorou J. Pomeranz B, Corey PN. “Incidence of adverse drug reaction in hospitalized patients. “JAMA 279 (1998):1200-1205 Medical Errors……………………….…7,4002 Unnecessary Surgery……………..…12,0003 Other Preventable Hospital Errors….20,000 Hospital Borne Infections………….…80,000 Adverse Drug Effects ……………....106,0004

  7. Prescription Practices among American Doctors Number of drugs ordered or provided: 2.0 billion Average number of drugs ordered or provided per visit: 2.1 Percent of visits involving drug therapy: 71 Most frequently prescribed therapeutic class: Antidepressants Source:U.S. DEPARTMENT OF HEALTH & HUMAN SERVICESCenters for Disease Control and Prevention

  8. Big Rx $ales winners in 2002 √ 1. Lipitor (cholesterol-lowering): $5.58 billion (up 18%)√ 2. Zocor (cholesterol-lowering): $4.069 billion (up 18%)√ 3. Prevacid (ulcers, reflux): $3.894 billion (up 4%)√ 4. Prilosec (ulcers, reflux): $3.341 billion(↓ 22% after going generic in 2002)5. Procrit: >$2 billion, exact numbers N/A√6. Zyprexa (neuroleptic): $2.716 billion (up 15%) √ 7. Paxil (SSRI antidepressant): $2.509 billion (up 13%)√ 8. Zoloft (SSRI antidepressant): $2.445 billion (up 13%) 9. Epogen: >$2 billion, exact numbers N/A√ 10. Celebrex (anti-inflammatory): $2.380 billion (up 5.3%)√ 11. Nexium (ulcers, reflux): $2.000 billion (new drug) 12. Neurontin (seizures, pain): $2.000 billion√ 13. Norvasc (antihypertensive): $1.814 billion (up 5%)

  9. Per Capita Total Current Health Care Expenditures, U.S. and Selected Countries, 2006 US Ranking # 1 Responsiveness # 1 Expenditures # 37 Performance # 72 Health WHO data (n=191 Countries) Source: Organization for Economic Co-operation and Development. OECD Health Data 2008, from the Source OECD Internet subscription database updated October 2008.

  10. The Changing American Diet • 1900 – industrialization/urbanization; local grocers Challenge: How to extend the shelf-life of foods? • 1940s – nutritional deficiencies  Enrichment Act • 1950s – Animal proteins (meat & milk) promoted • 1960s – Growth of fast food chains; “diet” pills emerge • 1970s – Food Pyramid developed (anti-fat campaign) HFCS enters food supply Trans (hydrogenated fats) enter the food supply • 1980s – Microwave ovens; loss of family dinner hour • 1990s – “Super-sizes” • 2000s – ? 10

  11. Diet and CancerIncrease RiskDecrease Risk Meats Dairy Total Fat Saturated Fat Refined Sugar Total Calories Alcohol Fish Whole grains Legumes Cabbages Broccoli, cauliflower, cabbage Vegetables Nuts Fruits 11

  12. Preventing Heart Disease High Blood Pressure – diet, exercise, ideal weight Diabetes – diet, exercise, ideal weight Elevated Cholesterol - diet, exercise, ideal weight Smoking – STOP! Family history - ? 12

  13. Percent of Avoidable Chronic Diseases 91% 82% 71% 70% Source:The Culprit & The Cure, p 5; Steven G. Aldana, PhD. Maple Mountain Press, 2005. NEJM 2000. July 6:343(1);16-22, Cancer Causes Control 2000. August;11(7):579-88, NEJM 2001.Sept 13;345(11):790-7

  14. Sometimes in our quest for wellness, we fail to see that WE are the solution!

  15. A Truth:The body is designed to heal itself • Digestive System = absorbs nutrients • Cardio Pulmonary System = circulates nutrients • Renal System = removes waste products • Nervous System = communication center • Endocrine System = relay system • Immune System = protects against cancer/microbes

  16. The Miraculous Cell • Each cell has it’s own unique machinery to repair & heal itself. • MILLIONS of DNA repairs occur each second. • Every day 10,000 free radicals attack the DNA of EVERY cell • Each cell contains “organs” • A lesson of harmony, balance, order & interdependence • Cells sense and respond to their environment • Redox potentials (ORP) signal imbalance (stress) and initiates cellular repair • Cells communicate with and warn each other • All proteins, lipids, nucleic acid interact with water

  17. Lessons from Nature • Stress & Recovery • We are designed to adapt to short-term bursts of stress, NOT chronic! • Day and Night • Summer and Winter • Muscular stress & Recovery • Stress & Recovery in Healing?

  18. Our health is primarily threatened by … STRESS

  19. STRESS An imbalance of forces

  20. Healing & Wellness Balance (Harmony with natural law) Stress Imbalance (disharmony with natural law) Dysfunction & Disease

  21. Oxidative Stress THE mechanism of disease AND aging

  22. “Unpaired”, negatively charged particles Move at very high speeds “Steal” electrons from adjacent molecules, making them “unstable” and reactive Like sparks from a fire (lifespan is 1 trillionth of a second) Free Radicals were proposed as the root cause of AGING in1956 (Harman D. Aging: Theory based on free radical and radiation chemistry. J Gerontology 11:298-300, 1956.) Oxidative stress via “Free Radicals”

  23. Sources of Free Radicals • Normal respiration & metabolism • Exercise • Microbes: viruses, bacteria, parasites, fungi • Air pollutants, pesticides, herbicides, tobacco • Radiation: X-rays, UV light & microwaves • Drugs (alcohol, medications, etc) • Dietary • Fats (esp. hydrogenated fats, rancid fats, fried fats, or charred fats) • High sugar diets • Stress (cortisol) • Injury/trauma

  24. Free RadicalsReactive Oxygen Species (ROS) • Superoxide anion radical (O2 . -) • Singlet Oxygen (1O2) • Hydroxyl radicals (OH-) • Hydrogen Peroxide (H2O2) ROS have a positive ORP !

  25. Free Radicalsthe good, the bad, the ugly • Immune processes generate free radicals to destroy microbial invasion • A byproduct of ATP synthesis and cellular detoxification • Oral (food/medications) and air-borne free radical exposures can be significant • ONE puff of cigarette smoke contains how many free radicals? • Answer: 100,000,000,000,000,000 !!!

  26. Ionizing radiation Exercise STRESS!!!

  27. Free radicals & oxidative stress

  28. Free Radicals and Oxidative Structural Damage • Damages collagen cross-links → wrinkles • Damages elastin in arteries → hypertension • Damages intimal lining → atherosclerosis (hs-CRP) • Damage to DNA/RNA → mutations, inefficient repair processes and cancer • Damage to Insulin Receptor → diabetes

  29. Nature’s PrescriptionagainstFree Radical Damage

  30. Cellular Anti-oxidants • Cell membrane protection • Vitamin E and beta-carotene • Extracellular fluid protection • Vitamin C and Glutathione • Intracellular protection • Glutathione, Vitamin C, Selenium • CoQ10 (mitochondria) • Melatonin (protects brain nDNA and mDNA)

  31. Cellular Anti-oxidants • Vitamins A (β-carotene), E, C • Selenium, Zinc, Manganese, Copper, Iron • Glutathione (GSH) • α-Lipoic Acid • N-acetylcysteine

  32. Anti-oxidants regenerate each other • Vit C + Vit E + Selenium β-carotene • CoQ10 in mitochondria  Vit E • α-Lipoic Acid + proanthocyanidines  Vit C

  33. With nearly all vegetables, conventional boiling reduces the ORAC value significantly, while steaming retains more of the antioxidants

  34. Anti-oxidant Supplements(Anti-Free Radicals)

  35. Anti-oxidants • Herbs • Turmeric, Ginko • Supplements • CoQ10, DHEA-S, Grape Seed Extract, Lipoic Acid, Lycopene • Enzyme Systems (require adequate Se, Cu, Mn, Zn, Fe) • Catalase • Super Oxide Dismutase (SOD) • Glutathione Peroxidase

  36. Acidic Stress A precursor to Oxidative Stress

  37. Acids Loads • Blood pH range is 7.35 – 7.45 • Acid is a byproduct of cell metabolism and repair, yielding a net gain in acid load • i.e. Urine pH is 6.0 (not 7.4) due to acid excretion • The body must maintain relative neutrality by buffering systems • 3 systems suggest the importance of acid-base balance (fluid buffers, kidneys, lungs)

  38. Acids, Bases, Buffers & Balance • Lungs • The primary buffer of blood pH; • 1-2 times as potent as chemical buffers (fast) • Kidneys • The secondary buffer of blood pH; (slow) • urine pH=6.0 • Chemical Buffers • Intracellular • Proteins – provides ¾ of all chemical buffering • Bone via Calcium carbonate and Calcium phosphate • Extracellular • Fluids Buffers • Sodium Bicarbonate • Sodium Phosphate Guyton A., Textbook of Medical Physiology;8th Ed, 1991, WB Saunders Co.

  39. pH of various body fluids • Inside Cell 7.2-7.4 • Blood 7.4 • Urine 6.0 • Stomach 2.5 • Intestines 8.0 • Skin 4.5-6.0 • Saliva 6.0-7.4 • Vagina 3.8-4.5

  40. Acidic Loads ?

  41. Chronic Acidic States • Acid Reflux • Cancer • Gout • Kidney Stones • Osteoporosis • Dental Disease

  42. Alkaline Foods Spinach Broccoli Olive Oil Apples Almonds Carrots Cabbage Acid Foods Coffee White Bread Beef Pastries Pasta Dairy products Soft Drinks D D

  43. Alternative Therapies, Jul/Aug 2007, Vol. 13, No. 4, p 62-65. Over time, ingestion of a high dietary acid load can progress to a chronic low-grade level of metabolic acidosis…. Increasing evidence suggests that such persisting, allbeit low-grade, acidosis, and the relentless operation of responding homeostatic mechanisms, result in numerous injurious effects on the body including dissolution of bone, muscle wasting, kidney stone formation, and damage to the kidney.

  44. Acid or Alkaline? Otto Warburg Nobel Peace Prize 1931 Discovered The Cause of Cancer Cancer thrives in an acidic, oxygen-depleted environment Excess sugars & processed flour, dairy, meats, soft drinks, STRESS Inactivity → oxygen depletion Cancer cannot grow in an alkaline, oxygen-rich environment

  45. Dehydration Stress

  46. Dehydration • We are 75% water • We are one big biochemical reaction • Water is the ideal solvent • Thirst mechanism activated after we are 5% dehydrated • We are dehydrated in the morning • Caffeine is the most common diuretic on the planet • Youngsters dehydrate faster than adults

  47. Dehydration States • Physical activity • Sun/heat exposure • Aging • Sleep • Constipation • Kidney stones • Diuretic use

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