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Storyline MD3

Storyline MD3. Medicines that send messages to nerves. Designer medicines. Need a biological understanding of the disease Need a lead compound – provides a lead / gives some clues. Adrenal gland. Flight. Fight. Adrenaline. Increases blood pressure Increases heart rate

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Storyline MD3

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  1. Storyline MD3 Medicines that send messages to nerves.

  2. Designer medicines • Need a biological understanding of the disease • Need a lead compound – provides a lead / gives some clues.

  3. Adrenal gland Flight Fight • Adrenaline • Increases blood pressure • Increases heart rate • Dilates bronchioles

  4. NORADRENALINE • NEUROTRANSMITTER • Fits into and interacts with receptor sites so: • Increases blood pressure • Increases heart rate • Dilates bronchioles • Increases sweating

  5. Asthma

  6. ISOPRENALENE • AGONIST • Fits into and interacts with 3 receptor sites so: • Increases blood pressure • Increases heart rate • Dilates bronchioles • NORADRENALINE • NEUROTRANSMITTER • Fits into and interacts with receptor sites so: • Increases blood pressure • Increases heart rate • Dilates bronchioles • Increases sweating Can be dangerous!

  7. SALBUTAMOL • AGONIST • Selective – only fits into one receptor site. • Dilates bronchioles. Also CH2OH slows down breakdown.

  8. SALMETEROL AGONIST Longer lasting protection

  9. Do Ass 6 and 7.

  10. Pharmocore – group of atoms which make the molecule pharmacologically active.

  11. The structural fragment which is the pharmocophore has: • A shape which precisely fits that of the receptor site • Functional groups which are correctly positioned to interact with the receptor site. • This is called molecular recognition.

  12. Are they all the same colour? chromophore

  13. Solubility?

  14. Agonists and antagonists Salbutomol is an agonist – behave like a natural substance from the body.

  15. Antagonists

  16. Do Ass 8

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