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The Genomic, Epigenomic , and Quality of Life Characteristics of Long-Term Survivors of Ovarian Cancer: A Department of Defense-Funded Project. Michael Birrer, PI, Director, Gynecologic Medical Oncology, MGH Lari Wenzel, Co-PI, Prof. of Medicine, University of California, Irvine

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The Genomic, Epigenomic, and Quality of Life Characteristics ofLong-Term Survivors of Ovarian Cancer:ADepartment of Defense-Funded Project

Michael Birrer, PI, Director, Gynecologic Medical Oncology, MGH

Lari Wenzel, Co-PI, Prof. of Medicine, University of California, Irvine

longtermsurvivors@gmail.com

Finding the Key to Long-Term Survival for All Women

ovarian cancer a deadly disease with hope
Ovarian CancerA Deadly Disease with Hope

23,000 women in the USA each year are diagnosed with

Ovarian Cancer

80% have an advanced stage cancer (Stage III or IV)

16,000 women in USA die of Ovarian Cancer each year

But 10% Do Survive Long Term !

Finding the Key to Long-Term Survival for All Women

who are we
Who Are We?

Finding the Key to Long-Term Survival for All Women

why am i still alive
Why Am I Still Alive?

What is different about long-term (10+ years) survivors?

Is it something about the patient or the tumor or both?

What are the long-term consequences of the diagnosis and

treatment of ovarian cancer?

Finding the Key to Long-Term Survival for All Women

goals
Goals

PROs

QOL

Finding the Key to Long-Term Survival for All Women

a holistic approach study
A Holistic Approach Study
  • Identify Stage 3 or 4 Ovarian Cancer Long-Term Survivors
  • Collect Tissues and Characterize
    • Molecular markers (genetic, biochemical, immunology)
    • PatientQuality of Life
  • Identify a Link Between 1 and 2
  • Establish Clinical Tools and Targeted Therapies

Finding the Key to Long-Term Survival for All Women

consortium structure
Consortium Structure

PATIENTS

Scientific Advisory Board

Chair: Phil DiSaia

Advocate Advisory Board

Chair: Mary Scroggins

Coordinating Center: MGH

PI: Michael J. Birrer

Co-PI: Lari Wenzel, Ph.D.

Scientific Committee

Research Sites

GOG Clinical Trials

39 Institutions

GOG Tissue Bank

39 Institutions

Genomic, Biologic, Psychosocial

Data Collection

Clinical Conclusions: Tools and Targets

the gynecology oncology group
The Gynecology Oncology Group

Tissue Repository

Patients Database

50 Principal Centers and 187 Participating Hospitals

Multi-Modality Group with Over 2100 Participants

GOG Clinical Trials Brought ALL the Major Improvements

in the Management of Ovarian Cancer

Finding the Key to Long-Term Survival for All Women

the advocate advisory board
The Advocate Advisory Board

Ensures the project remains patient- and goal-focused, scientifically sound, and clinically relevant

Finding the Key to Long-Term Survival for All Women

what is needed
What Is Needed?

Identification of Long-Term Survivors (10+ years) with Advanced Stage Ovarian Cancer (Stage III and IV only)

Paraffin-Embedded Tumor Specimen from

ANY Biopsy or Surgery

“Quality of Life”, Toxicity and Medical Treatment Reports

Finding the Key to Long-Term Survival for All Women

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Without You…….Nothing Can Happen!

Please Contact

The Long-Term Survivors Group: longtermsurvivors@gmail.com

Finding the Key to Long-Term Survival for All Women