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PROGNOSIS dan PREDIKTIF pada KANKER. d r. Daan Khambri, SpB(K)Onk, M.Kes Subbagian Bedah Onkologi, Bagian Bedah FK-UNAND / RS UP Dr.M.Djamil. Dr. H. Daan Khambri, SpB (K) Onk, M.Kes Dokter Spesialis Bedah Konsultan Bedah Onkologi / HNB (Bedah Tumor) Lahir di DUMAI, tanggal 6 Mei 1967.

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prognosis dan prediktif pada kanker

PROGNOSIS dan PREDIKTIF pada KANKER

dr. Daan Khambri, SpB(K)Onk, M.Kes

Subbagian Bedah Onkologi, Bagian Bedah FK-UNAND / RSUP Dr.M.Djamil

slide2

Dr. H. Daan Khambri, SpB (K) Onk, M.Kes

Dokter Spesialis Bedah

Konsultan Bedah Onkologi / HNB

(Bedah Tumor)

Lahir di DUMAI, tanggal 6 Mei 1967

Pendidikan : SD, SMP, SMA di DUMAI s/d Th 1985.

S1 – Dokter Umum (FK-UNAND Padang, 1991).

Sp1 – Spesialis Bedah (FK-UNAND Padang, 2003).

S2 – Magister Kesehatan (FK-UNPAD Bandung, 2007).

Sp2 – Konsultan Bedah Onkologi (FK-UNPAD Bandung, 2007).

Pekerjaan :- Staf Subbagian Bedah Onkologi, Bagian Bedah FK-UNAND /

RSUP Dr.M.Djamil

Organisasi Profesi :IDI, IKABI, PABI, PERABOI, POI

Riwayat Pekerjaan : 1992-95 PUSKESMAS Rantau Pandan Bungo Tebo JAMBI.

1995-96 PUSKESMAS SALIMPAUNG Tanah Datar SUMBAR.

2003-04 RSUD SUNGAI DAREH Kab. DHARMASRAYA.

2007- RSUP Dr.M.Djamil / FK-UNAND Padang.

Padang, 2011

Curiculum Vitae

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

buku rujukan
BUKU RUJUKAN
  • Bradley KT. CAP Cancer Committee. Prognostic and Predictive Factors in Breast Cancer. Newspath. Sept 1. 2007.
  • UICC, International Union Against Cancer. Prognostic Factors in Cancer. 3rd Ed. 2006.
  • Gede Sukardja. Onkologi Klinik. Edisi 2. 2000.

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

cara terapi kanker
CARA TERAPI KANKER
  • SURGERY
  • RADIATION THERAPY
  • CHEMOTHERAPY
  • HORMONAL THERAPY
  • MOLECULAR-TARGET THERAPY

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

combination therapy multimodalitas
Combination Therapy : MULTIMODALITAS

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

prognostic factor
prognostic factor

Definisi :

  • a measurablevariable that correlates with the natural history of the disease

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

prognostic factor1
prognostic factor
  • Faktor yang dapat dipakai untuk meramalkan perjalanan penyakit kanker

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

prognostic factor2
PROGNOSTIC FACTOR
  • PENDERITA
  • TUMOR
  • TERAPI

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

penderita
PENDERITA
  • Umur
  • Kelamin
  • Suku Bangsa
  • Genetik
  • Status Umum
  • Status Penampilan
  • Imunitas
  • Co-Morbiditas
  • Gizi
  • Sosial Ekonomi

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

tumor
TUMOR
  • Topografi/Jenis Kanker
  • Morfologi/Patologi
  • Derajat Keganasan
  • Stadium
  • Luas Ekstensi Tumor
  • Lokasi dan luas meta
  • Reseptor Hormon
  • Petanda Tumor
  • Multisentris
  • Radio/Khemo sensitivitas

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

terapi
TERAPI
  • Jenis terapi
  • Lengkap / tidak
  • Radikalitas operasi
  • Respon terhadap terapi
  • Fasilitas
  • Keahlian Dokter
  • Kerjasama tim multidisiplin

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

p redictive f actor
Predictive Factor

Definisi :

  • is associated with response to a given therapy.

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

p redictive f actor1
Predictive Factor
  • Faktor prediksi adalah sesuatu yang berpengaruh secara spesifik terhadap jenis pengobatan tertentu

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

prognostic factors in breast cancer
Prognostic Factors inBreast Cancer
  • Age
  • Tumor size
  • Axillary node status
  • Histological tumor type
  • Pathologic grade
  • Hormonal receptor
  • HER-2/neu

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

breast cancer stage i
BREAST CANCERStage I

T1 N0 M0

T1a: T  0.5 cm

T1b: 0.5 cm < T  1 cm

T1c: 1 cm < T  2 cm

T1

T  2 cm

N0 = no regional lymph node metastasisM0 = no distant metastasis

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

breast cancer stage iv
BREAST CANCERStage IV

Any T any N M1

M1 = distant metastasis (including metastases to ipsilateral supraclavicular, cervical, or contralateral internal mammary lymph nodes)

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

reseptor hormon
RESEPTOR HORMON
  • Estrogen reseptor (ER)
  • Progesteron Reseptor (PR)
  • Epidermoid growth factor reseptor (EGFR) / Her2

Daan K, Blok 2.1 Prognosis & Prediktif Kanker

jenis reseptor
JENIS RESEPTOR
  • Reseptor hormon positif
  • Reseptor hormon negatif

Reseptor hormon menentukan sensitivitas kanker

terhadap hormon

Daan K, Blok 2.1 Prognosis & Prediktif Kanker