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Board Review. Paul O’Keefe April 16, 2003. Skin/Soft Tissue Infections. Impetigo Cellulitis Fasciitis. Impetigo. Group A streptococcus, Staphylococcus arueus Superficial blisters honey colored crusts on erythematous base No systemic signs Mainly in children

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board review

Board Review

Paul O’Keefe

April 16, 2003

skin soft tissue infections
Skin/Soft Tissue Infections
  • Impetigo
  • Cellulitis
  • Fasciitis
impetigo
Impetigo
  • Group A streptococcus, Staphylococcus arueus
  • Superficial blistershoney colored crusts on erythematous base
  • No systemic signs
  • Mainly in children
  • May be associated with glomerulonephritis
  • Treat with penicillin/antistaphylococcal penicillin
cellulitis
Cellulitis
  • Deeper infection usually involving skin and subcutaneous tissue
  • Erythema, pain and swelling often with distinct border (erysipelas)
  • Fever and lymphangitis or adenitis common
  • Gp A streptococcus, Staphylococcus aureus most common
  • Treat with antistaphylococcal penicillin unless culture positive
necrotizing fasciitis
Necrotizing Fasciitis
  • Streptococcal gangrene (Gp A strept)
  • Deeper infection involving fascia and often muscle
  • Extreme toxicity and rapid spread (“flesh-eating virus”)
  • May have associated toxic shock
  • Treatment – surgical removal of necrotic tissue and antibiotics
    • Penicillin and clinidamycin
slide6
Staphylococcus aureus

Coagulase negative staphylococcus

Streptococcus pyogenes

Sterptococcus pneumoniae

Enterococcus faecalis

A three year old boy presents with an itchy rash that is spreading. Afebrile with numerous cursted lesions in erythematous base involving left shoulder and upper chest and back with few lesions in the right thigh. Culture growing gram positive coccus, beta hemolytic on SBA, catalase negative, inhibited by bacitracin disc. The isolated agent is

slide7

A 13 year old develops high fever and a severely

  • painful red rash on the right arm beginning at the
  • site of a minor laceration. He has high fever, hypo-
  • tension and extreme toxicity. The arm is red, very
  • swollen, firm and there are areas of black discolor-
  • ation of the skin. The remainder of the skin has a
  • red sunburned appearance. The extreme toxicity
  • is thought to be caused by
  • Streptolysin O
  • Hyaluronidase
  • M Protein
  • Pyrogenic exotoxin
  • Peptidoglycan
upper respiratory tract infection
Upper Respiratory Tract Infection
  • Pharyngitis
  • Sinusitis
  • Otitis media
pharyngitis
Pharyngitis
  • Viral
  • Group A streptococcus (S. pyogenes)
  • Corynebacterium diphtheriae
  • Infectious mononucleosis
pharyngitis and fatigue
Pharyngitis and Fatigue

A 15 year old presents with fever, sore throat and extreme

fatigue. Temperature is 103.2 and there is a yellowish exudate

covering both enlarged tonsils. Submandibular, anterior cer-

vical, and posterior cervical lymph nodes are enlarged on both

sides. Which of the following is most characteristic of infectious

mononucleosis?

  • Atypical lymphocytosis
  • Positive culture for Group A streptococcus
  • Neutrophilia with left shift
  • Low serum globulin
  • Hematuria
sinusitis
Sinusitis

A 15 yo woman presents with fever, facial pain and severe

nasal congestion. She has been suffering with hay fever.

CT showed opacification of the R maxillary sinus and an air-

fluid level in the left. Gram stain of material obtained by

antral puncture disclosed gram negative coccobacilli. Which of

the following characterizes the organism most likely respon-

sible for the infection?

  • Requires neither X nor V factor for growth
  • Requires X factor but not V factor
  • Requires V factor but not X factor
  • Requires both X and V factors
  • Exuberant growth on sheep blood agar
otitis media
Otitis Media

A 9 month old child with fever and congestion is diagnosed

with right otitis media. Common causes of this infection are?

  • Gp A streptococcus and Gp B streptococcus
  • Neisseria meningitidis and Streptococcus pneumoniae
  • Streptococcus pneumoniae and Haemophilus influenzae
  • Haemophilus parainfluenzae and Gp A streptococcus
  • Staphylococcus aureus and Gp A streptococcus
community acquired pneumonia
Community Acquired Pneumonia
  • Streptococcus pneumoniae
  • Mycoplasma pneumoniae
  • Legionella pneumophila
  • Haemophilus influenzae
  • Chlamydia pneumoniae
  • Tuberculosis
community acquired pneumonia15
Community acquired pneumonia

A 33 year old male presents with fever and cough 3 weeks

after his 7 year old son was treated for pneumonia. X-ray

shows a patchy bronchopneumonia involving the right middle

and lower lung field. Cold agglutinin test is positive

What is the likely cause?

communinty acquired pneumonia
Communinty Acquired Pneumonia

A 26 year old woman complained of fever, night sweats and

cough for 2 months. She had occasional hemoptysis and 15

pound weight loss. Chest x-ray showed fibronodular infiltrates

with a cavity in the posterior segment of the right upper lobe.

Please answer the following:

What type of isolation would you order?What diagnostic tests would you order?

Sputum smear returned positive for AFB.

What treatment would you order?

Why are multiple drugs necessary for treatment of tuberculosis?

cause of diarrhea 4 hours after eating fried rice
Cause of diarrhea 4 hours after eating fried rice
  • B. cereus
  • S. aureus
  • Salmonella
  • Shigella
  • C. jejuni
  • Yersinia enterocolitica
  • Vibrio parahemolyticus
contaminated poultry is the most likely source of
Contaminated poultry is the most likely source of
  • Salmonella
  • Vibrio cholerae
  • Shigella dysenteriae
  • Campylobacter jejuni
  • S. aureus
slide22
An important virulence factor of the organism found on biopsy of the stomach in patients with chornic epigastric pain is
  • Enterotoxin
  • Polysaccharide capsule
  • Endotoxin
  • Urease
  • Beta-lactamase
urinary tract infection
Urinary Tract Infection

A 23 year old woman presents with acute dysuria one

day after intercourse. Urinalysis discloses 15-20 WBC’s

/HPF. Gram stain discloses gram negative rods.

What is the recommended treatment?

  • Penicillin V
  • Erythromycin
  • Trimethoprim/sulfamethosoxazole
  • Gentamicin
  • Clindamycin
which of the following strongly favors the diagnosis of pyelonephritis
Which of the following strongly favors the diagnosis of pyelonephritis?
  • Burning on urination
  • Hematuria
  • Suprapubic tenderness
  • Fever
  • WBC casts on urinalysis
meningitis
Meningitis

A 6 year old boy presents with fever and lethargy. He has

nuchal rigidity on examination. Lumbar puncture discloses

many PMN’s and Gram positive cocci in pairs.

Which of the following characterizes this organism?

  • Beta hemolytic on sheep’s blood agar
  • Inhibited by bacitracin dise
  • Inhibited by optichin disc
  • Beta-lactamase positive
  • Growth on MacConkey agar
vaccines are available to prevent meningitis caused by which organisms
Vaccines are available to prevent meningitis caused by which organisms ?
  • E. coli and Streptococcus pneumoniae
  • Haemophilus influenzae and Listeria monocytogenes
  • Group B streptococcus and E. coli
  • Neisseria meningitidis and Haemophilus influenzae
  • Streptococcus pneumoniae and Group B streptococcus
bone and joint infections
Bone and Joint Infections

A 22 year-old woman with sickle cell disease presents with

fever and pain in the left upper arm. X-ray of the humerus

shows a lytic lesion. Biopsy is growing gram negative

Bacilli.

Which of the following best describes the organism?

  • Comma-shaped with single polar flagellum
  • Motile and oxidase positive
  • Nonmotile facultative anaerobe
  • Motile and does not ferment lactose
  • Coccobacilli that require X and V factors
sexually transmitted diseases
Sexually Transmitted Diseases

A 16 year old man presents with burning on urination and a

scant urethral discharge 3 days after intercourse with a new

partner. Gram stain of discharge discloses many PMN’s but

no bacteria.

The organism most likely responsible for the infection is

  • Gram positive coccus, catalase positive
  • Gram positive coccus, catalase negarive, beta-hemolytic
  • Has infectious elementary body and intracellular reticulate body
  • Gram negarive coccus, oxidase positive
  • Gram negarive rod, ixidase negarive lactose fermenting
arthritis
Arthritis

A 29 yo female presents with fever, rash and arthritis 5 days

after onset of menses. She has a new sex partner. Exam

discloses about 25 papular lesions on distal extremities and

inflamed tendon sheaths of the wrists and ankles with painful

motion but no fluid in the joints.

Cultures of blood and endocervix are growing

  • Catalase positive, gram positive coccus
  • Gram negative coccus that ferments glucose but not maltose
  • Gram negative coccus that ferments glucose and maltose
  • Gram negative coccus that requries X and V factors for growth
  • Gram negative bacillus that ferments lactose
neisseria gonorrhoeae undergoes antigenic variation by altering
Neisseria gonorrhoeae undergoes antigenic variation by altering
  • Antigenic structure of pilus or expression of outer membrane protein II
  • Antigenic structure of OMP II or expression of OMP I
  • Expression of polysaccharide capsule
  • Antigenic structure of pilus and expression of OMP I
  • Expression of cytochrome c (Oxidase)
lesion
Lesion

A 32 yo homosexual man presents with a painless lesion on

the penis of one week’s duration. It developed 3 weeks after

unprotected sex with an anonymous partner.

The cause of the infection is identified from a specimen obtained

from the lesion which shows.

  • Gram negative coccobacilli
  • Gram positive cocci in clusters
  • Gram negative diplococci
  • Gram negative bacilli
  • Motile corkscrew-shaped organisms on darkfield microscopy
response to treatment
Response to Treatment

A 20 yo asymptomatic woman in the 6th week of pregnancy has

a positive RPR of 1:16. FTA Abs is positive. She is treated with

3 doses of benzathine penicillin.

Follow up testing after treatment should demonstrate

  • Progressive rise in RPR and reversion of FTA Abs to negative
  • No fall in RPR and reversion of FTA to negative
  • Progressive fall in RPR and reversion of FTA to negative
  • Progressive fall in RPR while FTA remains positive
  • No change in RPR while FTA remains positive
discharge
Discharge

A 33 yo sexually active woman complains of vaginal discharge.

Examination of the greenish frothy discharge discloses pH of

5.5 with numerous WBC’s and organisms with a jerking motion

on saline wet mount.

Treatment is best accomplished with

  • Doxycycline for 5 days
  • Metronidazole – single dose
  • Ciprofloxacin – single dose
  • Ceftriaxone intramuscular – one dose
  • Benzathine penicillin G IM – one dose
fever and abdominal pain
Fever and Abdominal Pain

An 18 yo woman presents with fever and lower abdominal pain.

She has recently had intercourse with a new partner. Pelvic

examination discloses vaginal discharge, pain on motion of the

cervix and bilateral adnexal fullness.

Causes of these symptoms include?

  • Neisseria gonorrhoeae
  • Treponema pallidum
  • Chlamydia trachomatis
  • E. coli, Prevotella bivia, enterococcus
  • Herpes simplex
vaginitis
Vaginitis

A 35 year old woman complains of scant vaginal discharge and

itching. Exam discloses erythema of the vaginal mucosa with

patches of white discharge. The pH is 4.3.

What is appropriate treatment for this condition?

  • Metronidazole for 5 days
  • Ciprofloxacin – one dose
  • Doxycycline for 5 days
  • Topical acetic acid
  • Topical miconazole
plague yersinia pestis
Plague – Yersinia pestis
  • Highly virulent, encapsulated, small gram negative rod
  • Endemic in wild rodents Europe and Western N. America
  • Transmitted by flea
  • Virulence: endotoxin, exotoxin, proteins
  • Spreads to nodes – Buboes, severe sepsis
  • Pneumonic plague – droplet spread
  • Diagnosis – aspirate bubo, blood (careful in lab)
  • Treatment – Gentamicin, Streptomycin, tetracycline
pastuerella multocida
Pastuerella multocida
  • Short, gram-negative rod
  • Cellulitis or osteomyelitis following cat bite or dog bite
  • Treatment penicillin
anthrax bacillus anthracis
Anthrax – Bacillus anthracis
  • Gram positive, spore-forming rod with capsule “Box cars”. Spores in soil, on animal productrs
  • Enter through skin, alimentary, respiratory tracts
  • Toxin: Protective antigen, edema factor (cyclase), lethal factor
  • Painless ulcer with marked local edema
  • Pneumonia (mediastinitis) meningitis
  • Necrotizing enteritismeningitis
  • Diagnosis-culture
  • Treatment: ciprofloxacin+clindamycin+rifampin, penicillin if susceptible
tularemia
Tularemia
  • Francisella tularensis – small gram negative rod, enzootic in wild animals (rabbit)
  • Transmission – ticks or contact with dead animal
  • Clinical
    • Ulceroglandular – ulcer with swollen regional lymph nodes
    • Typhoidal – fever, adenopathy
    • Pulmonary
  • Diagnosis – Culture dangerous in lab; serology and direct fluorescence
  • Treatment – Gentamicin or tobramycin
brucellosis
Brucellosis
  • Small, slow growing gram negative rod
  • B. melitensis (goats, sheep), B. abortus (cattle), B. suis (swine)
  • Transmission – Occupation, milk
  • Small granulomas in lymph nodes, spleen, marrow
  • Fever, weakness, fatigue
  • Diagnosis – cluture blood and tissue, serology
  • Treatment – tetracycline, gentamicin
rocky mountain spotted fever
Rocky Mountain Spotted Fever
  • Tick borne rash illness caused by Rickettsia rickettsii, a small gram negative rod. Obligate intracellular parasite. Eastern and Midwestern US
  • Vasculitis – organism in endothelium
  • Fever, headache, weakness followed by rash, DiC and shock
  • Diagnosis: Clinical, serology, ElISA, Weil Felix (Culture dangerous)
  • Treatment – Doxycycline
q fever
Q Fever
  • Coxiella burnetti
  • Transmission – contact with infectious aerosol from cattle, sheep, goats. Parturient cats
  • Fever, headache, cough; frequent hepatitis, endocarditis
  • Diagnosis – serology
  • Treatment – Doxycycline
lyme disease
Lyme Disease
  • Borrelia burgdorferi – spirochete transmitted by Ixodes ticks
    • Reservoir – field mice and deer
  • Erythema migrans, meningitis, encephalitis
  • Heart disease, arthritis
  • Diagnosis – Serology ELISA and Western blot
  • Treatment – Doxycycline, amoxicillin, ceftriaxone
histoplasmosis
Histoplasmosis
  • Dimorphic fungus – mold in soil, yeast in tissue
  • Ohio and Mississippi river valleys, disturbed soil with bird droppings, bat caves
  • Small oval yeast in macrophages
  • Clinical
    • Pulmonary – acute pneumonia, chronic like tuberculosis
    • Disseminated in immunocompromised – esp AIDS
  • Diagnosis – Culture, Serology, Antigen in urine
  • Treatment – Self limited, Itraconazole, Amphotericin b
blastomycosis
Blastomycosis
  • Dimorphic fungus – large refractile yeast with broad based budding
  • Ohio, Mississippi, St. Lawrence river valleys, Great Lakes. Soil with decaying organic material
  • Clinical
    • Pulmonary, pneumonia (refractory)
    • Dissemination to skin common
  • Diagnosis – culture, histology
  • Treatment – Itraconazole, Amphotericin b
coccidioidomycosis
Coccidioidomycosis
  • Dimorphic fungus – mold in soil, spherule in tissue
  • Southwestern US (CA, AZ, NM, TX), Mexico. Arthrospores carried by wind
  • Clinical
    • Valley fever – flu, pneumonitis, erythema nodosum
    • Chronic pulmonary – thin-walled cavity, nodule
    • Disseminated – Filipinos, African Americans, Immunosuppressed, pregnant
      • Skin, bone, joint. CNS common – chronic meningitis
  • Diagnosis – Sperules in tissue, culture (DANGER), serology
  • Treatment – Amphotericin b, fluconazole, itraconazole
candida
Candida
  • Oval yeast with single bud. ‘Pseudohyphae’ in tissue. Many species. Germ tube distinguish C. albicans from others
  • Impaired defenses:
    • Mucosal disease – mouth, esophagus, vagina, skin (warm, moist areas)
    • Greater immune compromise – dissemination to many organs
  • Diagnosis – seen on KOH, Culture
  • Treatment
    • Topical – nystatin, azoles
    • Systemic – fluconazole, amphotericin b, caspofungin
cryptococcus neoformans
Cryptococcus neoformans
  • Oval, budding yeast with polysaccharide capsule
  • Ubiquitous in soil containing bird droppings. Inhaled
  • Compromised: AIDS, diabetes, malignancy, transplant
  • Lung infection
    • Aymptomatic nodule
    • Pneumonia
  • Meningitis common
  • Diagnosis – India ink on CSF, Culture, antigen in CSF and serum (follow titer during treatment)
  • Treatment – Amphotericin b + flucytosine, Fluconazole
aspergillus
Aspergillus
  • Mold (no yeast form), ubiquitous, several species (A. fumigatus most common), Airborne conidia
  • Manifestations
    • Hypersensitivity – sinusitis, asthma-like illness (ABPA)
    • Mycetoma – fungus ball in pre-existing lung cavity
    • Invasive – Severely immunocompromised. sinus and lung
      • Causes thrombosis and infarction
      • Disseminated especially to CNS
  • Diagnosis – culture and histology
  • Treatment – Amphotericin b, Voriconazole, itraconazole
zygomycosis
Zygomycosis
  • Mucor, Rhizopus, Absidia – saprophytic molds
  • Invade blood vessels in paranasal sinuses or lung
    • Progressive destruction across tissue planes
  • Diagnosis – culture, histology
  • Treatment
    • Surgical debridement
    • Amphotericin b, newer azoles
fever in returning traveler
Fever in Returning Traveler
  • Malaria if exposed
    • Africa – falciparum
    • India – vivix
  • Blood smear
  • Chloroquine plus primaquine, Quinine plus doxycycline
  • Typhoid fever. Fever, rash, splenomegaly
  • Dengue – fever and headache
scenarios
Scenarios
  • Returned from Philippines and passed a worm?
  • Young Mexican immigrant with headache and new seizure. CT Cysts in brain
  • Sepsis and severe diarrhea in WWII veteran who has just finished chemotherapy for NHL. Eosinophilia and microscopic worm in sputum