CRCHD: Cancer Health Disparities Research and Diversity Training Opportunities Mary Ann S. Van Duyn, PhD Center to Reduce Cancer Health Disparities NCI Division of Cancer Biology New Grantee Workshop March 12, 2014
URMs Truly Are Underrepresented in the Cancer Research Workforce Drew, ASBMB Today, Jan 2010.
Why is Diversity Important? • Broadens the research “lens” to include new viewpoints from those from diverse backgrounds • Enhances innovation and creativity in cancer research • Contributes to reducing cancer disparities by more effectively addressing existing disparities within the population • Promotes fairness in the use of public funds for cancer research • Consistent with NIH’s Commitment to Excellence: providing support for talented individuals to explore ideas at the highest level of inquiry
Probability of NIH R01 awards by Race and Ethnicity (FY 2000-FY 2006 ) (N = 83,188)
NCI CRCHD Mission Within CRCHD and Across the NCI Divisions, Offices and Centers • Leads NCI’s efforts in the training of students and investigators from diverse populations in cancer and cancer health disparities (CHD) research • Coordinates and strengthens the NCI cancer research portfolio in basic, clinical, translational and population-based research to reduce cancer health disparities
Basic Research – CRCHD/DCB Collaboration CRCHD R21/U01 • Understanding Biological Variations • Determining Mechanisms and Pathways • Creating Tailored Diagnostics/Therapies
Exploratory/Developmental Grant for Basic Cancer Research in Cancer Health Disparities (R21) PAR-12-094 To support pilot and feasibility studies and innovative mechanistic studies that investigate biological/genetic bases of cancer health disparities • All Eligible • Preliminary data is not required • $275K Direct Cost Limit for 2 year project period • http://grants.nih.gov/grants/guide/pa-files/PAR-12-094.html
Basic Cancer Research in Cancer Health Disparities (U01) PAR-12-095 To conduct basic, mechanistic research into the biological/genetic causes of cancer health disparities. • All Eligible • Preliminary Data Required • $250K Direct Cost Limit per year and not to exceed 5 years • http://grants.nih.gov/grants/guide/pa-files/PAR-12-095.html
R21/U01 Basic Research in Cancer Health Disparities (PAR-12-094/095) * 1 Lymphoma, 1 Liver Cancer, 1 Wilms‘ Tumor , 3 Multiple Cancers • Topics of U01 grants funded in FY 2013 • Role of Chemokine Receptors in Prostate Cancer Progression Disparities • Investigations on HPV Variants and Ethnic Disparities in Cervical Cancer • Metabolic Profiles and Racial/Ethnic Disparities in Breast Cancer • Topics of R21 grants funded in FY 2012 • Significance of Cancer Stem/Stem-like Cells in African-Americans with Colorectal Cancer • Viral and Immune Host Response Factors as Biological Bases of Disparity in Liver Cancer Survival among Asian Americans • Role Of MicroRNAs in Prostate Cancer among African-Americans • Glycation as a Mechanism Promoting Cancer Health Disparity • Significance of Mitochondrial DNA in African-American Prostate Cancer Patients
Provocative Questions RFA • Group A • Cancer Prevention and Risk • Group B • Mechanisms of Tumor Develop-ment or Recurrence • Group C • Tumor Detection, Diagnosis, and Prognosis • Group D • Cancer Therapy and Outcomes • Group D • Clinical Effectiveness R01 and R21 mechanisms are available for each PQ PQC – 3: How do variations in tumor-associated immune responses among patients from distinct well-defined populations, such as various racial/ethnic or age groups, contribute to differences in cancer outcomes? For more information: http://provocativequestions.nci.nih.gov/
Diversity Training Training CURE Promoting Workforce Diversity in Cancer Research (R21)
Continuing Umbrella of Research Experiences (CURE) Expand and extend the period of training Emphasize scientific areas of greatest need Increase the size of the talent pool TRAINEES Pre -doctoral Early Stage Investigators High School Undergraduate Postdoctoral
Continuing Umbrella Research Experiences HS Undergrad. Predoctoral Postdoctoral Early Stage Investigator Diversity Supplements R 0 1 Re-Entry Supplements NRSA Fellowships: F31 R21 NRSA Training Grants:T32S P30 Supplements for HS and UG students R25TS: Cancer Prevention and Control Clinical Oncology Training Grants: K12S Career Awards: K01 K08 K23 Transition Career: K22
Research Supplements to Promote Diversity and Re-Entry Research Supplements to Promote Diversity in Health-Related Research (Administrative Supplements http://grants.nih.gov/grants/guide/pa-files/PA-12-149.html • Improve the diversity of the research workforce • Students, post doctorates, and eligible investigators • Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Administrative Supplement) • http://grants.nih.gov/grants/guide/pa-files/PA-12-150.html • Individuals with high-potential to re-enter an active research career after an interruption for family responsibilities or other qualifying circumstances • Support for full-time or part-time research, salary and supplies within the missions of all the program areas of NIH.
Research Supplements to Promote Diversity and Re-Entry Research Supplements to Promote Diversity in Health-Related Research (Administrative Supplement) http://grants.nih.gov/grants/guide/pa-files/PA-12-149.html • Improve the diversity of the research workforce • Students, post doctorates, and eligible investigators • Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers (Administrative Supplement) • http://grants.nih.gov/grants/guide/pa-files/PA-12-150.html • Individuals with high-potential to re-enter an active research career after an interruption for family responsibilities or other qualifying circumstances • Support for full-time or part-time research, salary and supplies within the missions of all the program areas of NIH.
CURE – NRSA Fellowships (F31) • Ruth L. Kirschstein National Research Service Awards for Individual Pre-doctoral Fellowships • Pre-doctoral (up to 5 years) support for candidates in • biomedical, behavioral, or clinical sciences • Fellowship Requirements – Experienced mentor, enrollment in a • graduate school • Allowable Costs – Annual stipend for Fellow’s living expenses, • tuition & fees, and health insurance • Submission dates – 4/13, 8/13, 12/13 (Electronic Submission) • http://grants.nih.gov/grants/guide/pa-files/PA-10-109.html
Mentored Career Development Award (K01) • NCI Mentored Research Scientist Development Award to Promote Diversity (K01) • PAR-12-050 • BASIC & POPULATION SCIENCE • Individuals with research or health professional doctorate degree • 100K Salary/30K R&D; 3-5 years support • Submission Dates: 2/12, 6/12, 10/12
Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21) PAR-12-096 To improve the diversity of the research workforce by supporting and recruiting eligible investigators from groups that have been shown to be underrepresented. • Eligibility: Investigators from Diverse Backgrounds • Preliminary Data is not required • $275K Direct Cost limit for 2 year project period • http://grants.nih.gov/grants/guide/pa-files/PAR-12-096.html
Geographical Management Program (GMaP) • Foster team science • Promote cross-training in emergent areas of science and in basic, clinical, and population-based science • Enhance personalized career mentoring • Share successful training and research models • Link ESI from CURE to available academic job opportunities to build critical mass
Basic Cancer Health Disparities Research (R21 and U01) • Dr. Rina Das firstname.lastname@example.org • Community Networks Program Centers • Dr. Rina Das email@example.com • Dr. Liz Perruccio firstname.lastname@example.org • Dr. Precilla Belin email@example.com • Diversity Supplements and U54 • Dr. Alison Lin firstname.lastname@example.org • NRSA (F31 and T32S) • Dr. Anil Wali email@example.com • Supplements to the CURE (P30S, R25TS, K12S) • Dr. Alison Lin alision.Lin@mail.nih.gov • Career Development Awards (K) • Dr. John Ojeifo (K01, K08, K23) Ojeifojo@mail.nih.gov • Exploratory Grant (Diversity R21) • Dr. Anil Wali firstname.lastname@example.org • PACHE Program (P20, U54) • Dr. Carmen Moten email@example.com • CRCHD General Contact Number: 240-276-6170
Promoting the Mission New! New! http://crchd.cancer.gov