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Introduction. FACILITATING TRANSLATIONAL RESEARCH AND MEDICINE INSTITUTE FOR CANCER/STEM CELL BIOLOGY AND MEDICINE. Stanford School of Medicine Leadership Retreat January 30 - February 1, 2003. Principal Goals.

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Introduction l.jpg
Introduction

FACILITATING TRANSLATIONAL RESEARCH AND MEDICINE

INSTITUTE FOR CANCER/STEM CELL BIOLOGY AND MEDICINE

Stanford School of Medicine Leadership Retreat

January 30 - February 1, 2003


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Principal Goals

  • Broaden and help integrate basic research in stem cell biology and cancer biology.

  • Initiate and Expand translational research in Cancer/Stem Cell Biology and Medicine.

  • Support (or establish) clinical trials derived from Institute’s translational research.

  • Pursue an organizational structure to accomplish these goals.

    • NCI-designated Cancer Center; either a

    • Fully integrated Comprehensive Cancer Center, or a

    • Research Cancer Center


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Current Areas of Research Interests

Critical advances in research and medicine in last 10-15 years.

  • Hematopoietic Stem and Progenitor Cells and Transplantation

  • Other Adult Tissue or Organ Stem Cells

  • Stem Cell and Progenitor Cell Gene Expression Pathways: Self-Renewal

  • Cancer Stem Cells

  • Pluripotent Stem Cells

  • Nuclear Transplantation to Produce Pluripotent Stem Cells: Nuclear Reprogramming


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Research Collaborations

Current Stem/Cancer Cell Collaborations:

  • Developmental Biology (Scott, Fuller, Nusse and Kim)

  • Biochemistry (Spudich)

  • Ob/Gyn (Husain, Polan and Teng)

  • Neurology (Mobley)

  • Neurosurgery (Tse, Skirbol and Palmer)

  • Medicine/BMT (Shizuru, Negrin and JWBrown)

  • Pathology (Cleary;van der Rijn and Galli)

  • MCP (Nelson)

  • Urology (Shortliffe,pending)

  • Interdepartmental Mouse Gene Array Program (PBrown, Barsh, et al.)

  • Residents and MD Fellows from Pediatrics, Hematology, Pathology and Oncology.


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Teaching Programs

  • Interface with departmental and IDP graduate programs in:

    • Cancer Biology, Immunology, Development Biology, Neurosciences, Neurobiology, etc.

  • MSTP and future Stem Cell/Cancer Biology Scholarly Concentration for medical students.


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Faculty

  • Small number of Associates

  • Collaborative searches for Associate Faculty

  • Search: Deputy Director for Scientific Programs (Cancer Biology)

  • Search: Pluripotent Stem Cell Biologist

  • Deputy Director for Clinical Programs: Karl Blume

  • Large number of Affiliates

  • Located in departments

  • Access to “hotel” space in Institutes


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Expectations

Unique roles of Institute in Translational Research and Medicine:

  • All appointments of faculty associates only in basic to translational fields in cancer or stem cell biology

  • Affiliates have opportunity to apply for 2-3 year bench in Institute, selected by Steering Committee and Directorate

  • Specialized facilities in Institute available to Associates and Affiliates

  • Spearhead development of a NCI Cancer Center

  • Organize course and Medical Scholar track, including research and clinical training

  • In the future, if legal and feasible, provide human pluripotent stem cell lines derived from defined disease nuclei to Stanford investigators