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ISW TBE Int. Press Workshop 28.01.2010

ISW TBE Int. Press Workshop 28.01.2010. F.X.Heinz Changing endemic areas – proven effectiveness of TBE vaccination in the field. Kokkola. S-Norway 1998. Endemic areas of TBE virus in Europe. Skane 2001. Zealand 2009. Saarland 1994. Alps. Friuli 2003. Alpine valleys Higher altidudes.

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ISW TBE Int. Press Workshop 28.01.2010

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  1. ISW TBE Int. Press Workshop28.01.2010 F.X.Heinz Changing endemic areas – proven effectiveness of TBE vaccination in the field

  2. Kokkola S-Norway 1998 Endemic areas of TBE virus in Europe Skane 2001 Zealand 2009 Saarland 1994 Alps Friuli 2003

  3. Alpine valleys Higher altidudes Goat cheese transmission > 1,500 m altitude TBE in Austria: New sites of infection 2005 -2009

  4. Field effectiveness of vaccination against tick-borne encephalitisFranz X. Heinz*, Heidemarie Holzmann, Astrid Essl, Michael Kundi*Institute of Virology, Medical University of Vienna, Austria Vaccine 25: 7559-7567 (2007)

  5. Field effectiveness (FE) of TBE vaccination in different age groups within the regular vaccination schedule (Austria 2000 to 2006) A. best case Unvaccinated Regularly vaccinated Age group Incidence/100,000 Incidence/100,000 FE 95% CI 0-15 y 1.435 0.043 97.0 86.81-99.02 16-49 y 4.964 0.009 99.8 99.52-99.90 50-59 y 6.444 0.059 99.1 97.25-99.57 60+ y 6.790 0.075 98.9 97.88-99.32 Total 5.922 0.039 99.3 98.92-99.56 B. worst case Unvaccinated Regularly vaccinated Age group Incidence/100,000 Incidence/100,000 FE 95% CI 0-15 y 1.435 0.057 96.0 84.24-98.67 16-49 y 4.964 0.039 99.2 98.29-99.59 50-59 y 6.444 0.118 98.2 95.29-99.14 60+ y 6.790 0.113 98.3 96.99-98.97 5.922 0.079 98.7 97.98-99.09 Total FE ~ 99%

  6. Estimated number of TBE cases prevented by vaccination in Austria 2000 – 2006 Regularly vaccinated Irregularly vaccinated Cases in unvaccinated Prevented by vaccination Expected cases Observed cases Observed cases Expected cases Age group 0-15 y 22 3 101 1 22 119 16-49 y 157 2 11 349 1,132 1,486 50-59 y 71 3 327 3 120 441 60+ y 189 6 542 12 248 772 Total 2,102 27 739 2,800 439 14

  7. TBE in Austria and Czech Republic 1979-2009 Percent vaccinated No. of TBE cases Czech Republic (Nat. Ref. Center of Epidemiol., Prague) Austria Vaccination coverage in Austria (at least 1 vaccination)

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