Hepatocyte Growth Factor Signaling Pathway

1. Hepatocyte Growth Factor Signaling Pathway Hepatocyte growth factor (HGF) is produced by various types of cells. It has a wide distribution of tissues and can participate in the maintenance and renewal of vital organs such as liver, lung, and kidney, then promote the regeneration of these organs. The specific binding of HGF to the c-Met receptor protein induces a change in the confirmation of the c-Met protein, activates the tyrosine protein kinase (PTK) in the receptor's intracellular protein kinase phosphorylation of various substrate proteins, such as phospholipase (PLC γ ), phosphatidylinositol 3-kinase (PI3k), Gab1, Grb2 and other molecules containing Src homology. domain, which in turn leads to It activates the downstream signaling pathways (such as Ras/MAPK, PI3K/Akt, and STAT, etc.), which in turn amplifies the signal and finally transfers it into the transcriptional machinery in the nucleus, regulating cell proliferation, differentiation, contraction, movement, secretion, and division. In summary, the biological effects of HGF are diverse, and many studies have been carried out on them. They have certain reference value in the diagnosis and treatment of cardiovascular diseases, respiratory diseases, tumors, liver diseases, etc. At the same time, there are still many biological mechanisms and functions that are still unclear. It is still necessary to continue to explore. In recent years, HGF has attracted the attention of many scholars at home and abroad and has begun a lot of experimental research and made some new progress. Find more at: https://www.creative-diagnostics.com/hepatocyte-growth-factor-signaling-pathway. htm