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Cancer Biomarkers

Biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. So cancer biomarkers refer to a substance or process that is a sign of the presence of cancer in the body.

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Cancer Biomarkers

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  1. Cancer Biomarkers Biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. So cancer biomarkers refer to a substance or process that is a sign of the presence of cancer in the body. The biomarkers may be a molecule secreted by a tumor or a specific response of the body to the presence of cancer. Ideally, such biomarkers can be assayed in non-invasively collected biofluids like blood or serum. As cancer diagnosis is a difficult thing in early stage. So this is an urgent need, which detect noninvasive molecular to assist in the detection and diagnosis of cancers in a cost ‑ effective manner at an early stage, when curative interventions are still possible. With development of studies, a number of genes and protein based biomarkers have already been used at some point in patient care; including, AFP (Liver Cancer), BCR-ABL (Chronic Myeloid Leukemia), BRCA1 / BRCA2 (Breast/Ovarian Cancer), BRAF V600E (Melanoma/Colorectal Cancer), CA-125 (Ovarian Cancer), CA19.9 (Pancreatic Cancer), CEA (Colorectal Cancer), EGFR (Non-small-cell lung carcinoma), HER-2 (Breast Cancer), KIT (Gastrointestinal stromal tumor), PSA (Prostate Specific Antigen) (Prostate Cancer), S100 (Melanoma), and many others. Mutant proteins themselves detected by Selected Reaction Monitoring (SRM) have been declared to be the most specific biomarkersfor cancers because they can only come from an existing tumor.

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