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Aim

Prior housing conditions and sleep loss may affect recovery from brain injury in rats: A pilot study. Ronald G. Riechers, MD; Jaime L. Shuster, MA; Kathryn J. Bryan, PhD; Christopher Burant, PhD; Sherry L. Ball, PhD. Aim

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Aim

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  1. Prior housing conditions and sleep loss may affect recovery from brain injury in rats: A pilot study Ronald G. Riechers, MD; Jaime L. Shuster, MA; Kathryn J. Bryan, PhD; Christopher Burant, PhD; Sherry L. Ball, PhD

  2. Aim • Understand effect of combat-associated conditions such as sleep deprivation (SD) on subsequent traumatic brain injury (TBI). • Relevance • Combat operations are associated with high stress and prolonged SD. • TBI is signature injury of conflicts in Iraq and Afghanistan.

  3. Method • Tested 4 groups of rats: • 24 h of SD in isolation followed by TBI (SD+CCI). • No SD in isolation followed by TBI (no SD+CCI). • Normal housing followed by TBI. • Normal housing and no TBI. • Tested rats with beam walk test and adhesive removal test at baseline and 4, 7, and 14 days after TBI.

  4. Results • SD+CCI group: • Earlier recovery than no SD+CCI group. • No SD+CCI group: • Recovered slower than all other groups. • Data suggest that: • 24 h of preinjury SD results in faster recovery. • Novel or social isolation conditions impedes recovery.

  5. Conclusion • Combat environment may contribute to complexities associated with TBIs common in U.S. servicemembers.

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