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Bone Morphogenetic Protein. By: Kim Stephens. What is Bone M orphogenetic P rotein?. Stimulates a patient's own cells to induce the formation of  bone and cartilage Recombinant human bone morphogenetic protein-2 , or rhBMP-2 Generates and repairs bone faster and more reliably

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what is bone m orphogenetic p rotein
What is Bone Morphogenetic Protein?
  • Stimulates a patient's own cells to induce the formation of bone and cartilage
  • Recombinant human bone morphogenetic protein-2, or rhBMP-2
  • Generates and repairs bone faster and more reliably
  • Latest in bone growth enhancement
changing points
Changing Points

1965: Dr. Marshall Urist, UCLA Department of Orthopedic Surgery in Los Angeles, CA discovered that the proteins needed to heal bone was inside bones

1997: First clinical trial with 11 patients

2001: New Hampshire Spine Institute

  • Available in an oral form
    • A supplement for bone and joint health

Regenerative Medicine:

  • Delivered to the site of the fracture
  • Released gradually to allow bone formation
  • Delivery in a purified collagen matrix
potential applications
Potential Applications
  • Osteoinductive characteristics make BMPs valuable as an alternative to bone grafts
  • Other methods of delivering BMPs to patients are undergoing evaluation
  • Non-skeletal tissues
  • Organogenesis


BMP has only been FDA approved for one type of spinal fusion


Side effects are not fully understood

  • Less pain, shorter hospital stays
  • More rapid return to a normal life
  • As effective as bone grafts
  • Eliminate the need for bone transplantation
  • Avoids the potential side effects and complications of bone harvesting or grafts
  • Use of BMP will potentially extend beyond skeletal disease and injury
  • Approval from the FDA to use BMP’s for dental work
  • Better understand these proteins and their benefits
works cited
Works cited