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Commercial awareness of bioscience industry Dr. Daria Olijnyk Sistemic Ltd. Sistemic Ltd. - Corporate overview. Venture capital-funded (2009) Product development and service company HQ and Labs - Glasgow (UK); North American Sales Office – Boston (US)

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slide1

Commercial awareness of bioscience industry

Dr. Daria Olijnyk

Sistemic Ltd.

slide2

Sistemic Ltd. - Corporate overview

  • Venture capital-funded (2009)
  • Product development and service company
  • HQ and Labs - Glasgow (UK); North American Sales Office –

Boston (US)

  • broad IP portfolio of miRNA-based products

robust microRNA profiling

customised multilayered statistical and contextual analysis

Designed to identify the key miRNAs (kmiRs™) – biomarkers of phenotype,

together with their underlying biological interpretation to study changes

in biological systems

slide3

About miRNAs

  • Non-coding RNAs
  • Short (17-24nt), endogenous
  • Single stranded
  • Regulate gene expression by transcriptional

silencing and/or mRNA degradation

  • 1898 human miRNAs (miRBase v.18)
  • Target ~60% of human genes
  • miRNA signature is:
  • - Reproducible
  • - Highly conserved between species
  • - Tissue/cell type/biological process specific
  • - Discriminative of healthy and diseased tissue
  • - Analytically robust
  • - Potent in delivery of reliable biomarkers

Joshi S. R., et al. MicroRNAs-control of essential genes : implications for pulmonary vascular disease. Pulmonary Circulation. 1 (3) 357-364 2011

slide4

About Sistemic Ltd. Methodology

SistemQC™

SistemRNA™

  • Stem Cell Research
  • Cell Therapy
  • Bio processing
  • Drug Development
slide5

The utility of Sistemic Methodology

Novel, Potent and Broadly Applicable

SistemQC™

SistemRNA™

Cell Characterisation/Cell QC

Drug Discovery

  • Identity markers
  • Potency assays
  • Purity assessment
  • Differentiation staging
  • optimisation/monitoring
  • Benchmarking cell models
  • QC of batch-to-batch consistency
  • Positioning/Repurposing
  • Predictive and Investigative Toxicology
  • Discover robust companion biomarkers
slide6

The utility of Sistemic Methodology

Novel, Potent and Broadly Applicable

SistemQC™

SistemRNA™

Cell Characterisation/Cell QC

Drug Discovery

  • Identity markers
  • Potency assays
  • Purity assessment
  • Differentiation staging
  • optimisation/monitoring
  • Benchmarking cell models
  • QC of batch-to-batch consistency
  • Positioning/Repurposing
  • Predictive and Investigative Toxicology
  • Discover robust companion biomarkers
slide7

About SistemQC™

Cell identity and cell model evaluation

Private and confidential

slide8

The utility of Sistemic Methodology

Novel, Potent and Broadly Applicable

SistemQC™

SistemRNA™

Cell Characterisation/Cell QC

Drug Discovery

  • Identity markers
  • Potency assays
  • Purity assessment
  • Differentiation staging
  • optimisation/monitoring
  • Benchmarking cell models
  • QC of batch-to-batch consistency
  • Positioning/Repurposing
  • Predictive and Investigative Toxicology
  • Discover robust companion biomarkers
slide9

About SistemQC™

Adult mesenchymal stem cell discrimination

Private and confidential

slide10

Rapid growth at Sistemic continues

Commercial Sector

Sales continue to grow

Customer base expanded over 3 continents

slide12

Customer Base

Private and confidential

slide13

Rapid growth at Sistemic continues

Research and Development

Industrial collaborations

Commercial Sector

Academic collaborations

Sales continue to grow

Internal R&D

Customer base expanded over 3 continents

slide15

Rapid growth at Sistemic continues

Research and Development

Industrial collaborations

Commercial Sector

Academic collaborations

Sales continue to grow

Internal R&D

Customer base expanded over 3 continents

Company profile

Teaching

Plan to increase the number

of staff

Joined PhD studentship

BSc student placements

Plan to move to new

premises

slide16

Career progression

FROM ACADEMIA TO INDUSTRY

  • Becoming aware and able to identify transferable skills that you gain

throughout your academic career and life experiences

slide17

You will be surprised...

COMMUNICATION, MANAGMENT AND LEADERSHIP SKILLS

BSc in

Biotechnology

Erasmus-Socrates

placement

  • proactive
  • determination

Bar supervisor at

Blanket night club

Postgraduate

Teaching Assistant

and Tutor

PhD in Pubertal

Mouse Mammary

Gland Development

Research Technician

for MD Biosciences

Inflammation Discovery

Sciences

MRes in Biomedical

and Life Sciences

Mentoring

Charity work

  • time management skills
  • familiar with immunological techniques
  • used in drug development
  • ability to work under stress
  • ability to meet deadlines
  • team working skills
  • communication skills
  • good customer care
  • reliability and punctuality
  • broad set of project/time
  • management skills
  • broad set of written and oral
  • communication skills
  • organisation skills
  • leadership skills
  • team working skills and ability to work
  • unsupervised
slide18

Career progression

FROM ACADEMIA TO INDUSTRY

  • Becoming aware and able to identify transferable skills that you gain

throughout your academic career and life experiences

  • Be enthusiastic, flexible and prepared to spend time learning
  • and polishing a new set of skills needed to adapt a different way of
  • working/carrying out research
slide19

I still learn every day...

  • The way you talk about your research and results
  • Higher level of documentation
  • - lab book – evidence for patenting (very accurate, signed off by another person
  • every day, be aware not to put any personal observations that may prove
  • incorrect but may jeopardise patent application)
  • - client sample/analysis – standardised way of recording information
  • Experiments are carried out according to accepted/standard protocols proprietary

to the company (SSOP)

  • Another layer of communication skills – speaking to customers, company
  • representatives, company marketing
  • Small-medium company allows interactions with multidisciplinary team - often
  • you will be involved in a variety of different tasks
slide20

Career progression

FROM ACADEMIA TO INDUSTRY

  • Becoming aware and able to identify transferable skills that you gain

throughout your academic career and life experiences

  • Be enthusiastic, flexible and prepared to spend time learning
  • and polishing a new set of skills needed to adapt a different way of
  • working/carrying out research
  • Be open minded and versatile and not afraid to step out of your comfort

zone

  • “ To progress your carrier in industry you have to think about science
  • from a broader, more managerial, business-like perspective”
  • Jim Reid Chairman/CEO at Sistemic
slide21

There is hope!

o

  • Life Sciences has been identified by Government and Scottish
  • Enterprise as a key sector for Scottish economy
  • A lot of financial support for Life Sciences sector in Scotland
  • Scotland - one of the largest Life Sciences clusters in Europe (560 companies)
  • The number of jobs in Life Sciences sector are sill growing
slide22

Good luck!

daria.olijnyk@sistemic.co.uk