The Cleanse: Balancing the effects of the Environment on Your Health

1. The Cleanse: Balancing the effects of the Environment on Your Health Brought to you by Sam Russo ND, LAc Vermont Naturopathic Clinic

2. What is the Cleanse and Metabolic Detoxification? • Detoxification is primarily the act of taking fat soluble toxins and making them more water soluble in order to be eliminated from the body. • Detoxification is also called “biotransformation” as other necessary substances are transformed in this process Sam Russo ND, LAc Vermont Naturopathic Clinic

3. Other Concepts of Detoxification • Movement of lymphatic congestion in massage therapy, physical therapy and osteopathy • Transformation, resolution or drainage of dampness and phlegm in Chinese medicine • Elimination of ama in Ayurvedic Sam Russo ND, LAc Vermont Naturopathic Clinic

4. Multiple published studies, including those by the Centers for Disease Control, have clearly shown that we all are carrying burdens of multiple environmental toxins, such as : Sam Russo ND, LAc Vermont Naturopathic Clinic

5. Toxic Burden • EPA's limit of 1 microgram of mercury per gram of hair was exceeded in 21 percent (126 out of 597) of women of childbearing age tested. • A study of 285 four year old children in Michigan • DDT was present in >70%, PCB were present in >50% , PBB was present in >21 %. • A study of 5994 persons age 12-74 looked for 16 organochlorine compounds (OCC), which are common pesticides • 99.5% had p,p-DDE >_1 ppb up to 378.6 ppb • 17.2% had pBHC, 10.6% had dieldrin , 10.5% had p,p-DDT residues. • Increasing age, residing on a farm, and being male brought increased risk Sam Russo ND, LAc Vermont Naturopathic Clinic

6. Toxic Burden • Evaluation of 35 human adipose samples from autopsy of persons with no known occupational exposure to OCC revealed: • o,p-DDT - 54%, avg. .014 ppm, p,p-DDT -97%, avg. .294 ppm • o,p-DDE - 54%, avg. .008 ppm, p,p-DDE - 100%, avg. .679ppm • Dieldrin -100%, avg. .036 ppm • Oxychlordane -100%, avg. .095ppm • Heptachlor epoxide 100%, avg. .086 ppm • BHC - 100%, ave .163 ppm Sam Russo ND, LAc Vermont Naturopathic Clinic

7. Two Major Pathways ofHepatic Detoxification Fat Soluble Compound Phase I • Hydroxylation Reactions • Cytochrome P450 enzymes Phase II Conjugation Reactions (“attachment”) Activated Intermediate (Free Radical!) Water Soluble Compound Excretion Sam Russo ND, LAc Vermont Naturopathic Clinic

8. Imbalanced Hepatic Detoxification Increased Free Radicals in Circulation Fat Soluble Toxin Increased Phase I Activated Intermediate (Free Radical!) Phase II Conjugation Reactions (“attachment”) Decreased Water Soluble Compound Decreased Excretion Sam Russo ND, LAc Vermont Naturopathic Clinic

9. Two Major Pathways ofHepatic Detoxification Fat Soluble Compound Heavy Metal, Genetic predisposition, Solvents Decreased Phase I Back into circulation Decreased Phase II Decreased Decreased Decreased Water Soluble Compound Decreased Excretion Decreased Sam Russo ND, LAc Vermont Naturopathic Clinic

10. Increased Phase 1 Intermediates Damage to cellular structures occurs • DNA and RNA → impaired cell replication • Mitochondria → impaired energy production • Enzymes → impaired metabolism, energy production, immune function, neurotransmitter function… Sam Russo ND, LAc Vermont Naturopathic Clinic

11. So what about more radicals? It’s not just radicals that are a problem as Phase 1 Activation is necessary beyond detoxification For example: • Cholesterol to bile acids • Steroid metabolism • Vitamin D3 • Conversion of fatty acids to eicosanoids That is why “biotransformation” is a better term! Sam Russo ND, LAc Vermont Naturopathic Clinic

12. Symptom Picture of General Toxicity • General Symptoms • Malaise • Chronic fatigue • Headache, especially frontal • Waking with a “sour stomach” • Chronic mucous production • Poor exercise tolerance Sam Russo ND, LAc Vermont Naturopathic Clinic

13. Symptom Picture of Imbalanced Detoxifiers • Cycle of Pain & Inflammation • myofascial & joint pain • recurring headaches • chronic low grade fever • fatigue & malaise • Chronic Fatigue Syndrome • Fibromyalgia • Medication/ supplement /substance intolerance Sam Russo ND, LAc Vermont Naturopathic Clinic

14. How do you support detoxification? • Environmental modification • Diet • Exercise • Hydration • Botanical Medicine • Clinical Nutrients Sam Russo ND, LAc Vermont Naturopathic Clinic

15. What is the Cleanse? • Week 1: Priming of the detoxification pathways, removal of detoxification obstacles • Week 2: Core detoxification • Week 3: Transition and reintroduction of avoided foods • Lymphatic drainage massage and constitutional hydrotherapy each week. Sam Russo ND, LAc Vermont Naturopathic Clinic

16. Why do I need to come in for an office visit? • To rule out contraindications to a detoxification protocol • To address individual needs Sam Russo ND, LAc Vermont Naturopathic Clinic

17. Why do I need to get hydrotherapy? • Increases circulation throughout all tissues of the body • Improves all routes of elimination through the skin, lungs, digestive system, kidneys • Improves mobilization of stored fat soluble toxins to be eliminated Sam Russo ND, LAc Vermont Naturopathic Clinic

18. What are some symptoms of enhanced detoxification? Usually there is a period, a few days to a week, where you may experience minor complaints: • Headaches (often associated with caffeine withdrawal) • Muscle aches • Changes in digestive function • Decreased energy (possible through week 2) • Changes in mood Sam Russo ND, LAc Vermont Naturopathic Clinic

19. What will I gain from this program? • Increased vitality • Improved digestion • Chronic disease prevention • Education and self-empowerment These effects may take 1-2 weeks to develop. Note: this is not a weight loss program. Sam Russo ND, LAc Vermont Naturopathic Clinic

20. How do I participate in the Cleanse? Call Vermont Naturopathic Clinic to schedule your individual appointment and your weekly hydrotherapy sessions Sam Russo ND, LAc Vermont Naturopathic Clinic