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LB145 Sec 001-004. Happy Valentine’s Day!. Today’s Announcements. StudyNotes5 AND Homework4 are due on Tuesday Feb 19 th . **Download HW VERSION 2.0** Field Trip sign up – started! Glycolysis and the Krebs Cycle. Oxidative Phosphorylation, the ETC. Track the Carbons and Phosphates:

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slide1

LB145Sec 001-004

Happy Valentine’s Day!

today s announcements
Today’s Announcements
  • StudyNotes5 AND Homework4 are due on Tuesday Feb 19th.
  • **Download HW VERSION 2.0**
  • Field Trip sign up – started!
  • Glycolysis and the Krebs Cycle.
  • Oxidative Phosphorylation, the ETC.
slide6

Track the Carbons and Phosphates:

Glucose + ATP  Fructose-P + ADP

Fructose-P + ATP  P-Fructose-P

P-Fructose-P  P-CCC + P-CCC

P-CCC + P-CCC + 2NAD+ + 2Pi P-CCC-P + P-CCC-P + 2NADH

P-CCC-P + P-CCC-P + 2ADP  P-CCC + P-CCC + 2ATP

P-CCC + P-CCC + 2ADP  Pyruvate + Pyruvate + 2ATP

Glycolysis: What do you need to know?

methods of producing atp
Methods of Producing ATP

GLYCOLYSIS & CITRIC ACID CYCLE

Substrate-level phosphorylation occurs when ATP is produced by the enzyme-catalyzed transfer of a phosphate group from an intermediate substrate to ADP.

slide9

Campbell: Fig. 9-6-3

Electrons carried

via NADH and

FADH2

Electrons

carried

via NADH

Oxidative

phosphorylation:

electron transport

and

chemiosmosis

Citric

acid

cycle

Glycolysis

Pyruvate

Glucose

Mitochondrion

Cytosol

ATP

ATP

ATP

Substrate-level

phosphorylation

Substrate-level

phosphorylation

Oxidative

phosphorylation

slide10

Fig. 9-10

CYTOSOL

MITOCHONDRION

NAD+

NADH

+ H+

2

1

3

Acetyl CoA

Coenzyme A

Pyruvate

CO2

Transport protein

slide12

Fig. 9-11

Pyruvate

CO2

NAD+

CoA

NADH

+ H+

Acetyl CoA

CoA

CoA

Citric

acid

cycle

2

CO2

FADH2

3 NAD+

NADH

3

FAD

+ 3 H+

ADP +

P

i

ATP

bitter melon
Bitter Melon

Selling my Body to Science

Consume a cup of liquid glucose.

Consume capsules that contain bitter melon OR placebo.

Lie still on a bed with a dome over my head and allow breath to be analyzed for an hour.

QUESTIONS:

Q1: On a molecular level, what is happening if bitter melon aids weight loss?

Q2: On a molecular level, what is happening if bitter melon does not aid weight loss?

Q3: Why were they interested in the air I exhaled?

Q4: What do you think might happen to excess glucose in your body?

etc the main pieces
ETC: The main pieces
  • Complex I: NADH dehydrogenase
    • removes e- from NADH
    • pumps 4 H+ into inter-membrane space
  • Complex II: succinate dehydrogenase
    • moves e- from FADH2 to Q
  • Complex III: Cytochrome bc1
    • transfers e- from Q to Cytc
    • pumps 2 H+ into intermembrane space
  • Complex IV: cytochrome c oxidase
    • transfers e- from Cytc to O2
    • pumps 2H+ into intermembrane space
    • Q: ubiquinone, pumps 2 H+ into intermembrane space
  • Cytc: cytochrome c
    • e- shuttles
disrupting cellular respiration what happens if1
Disrupting cellular respiration:What happens if…..?
  • Cyanide
    • Binds to Cytochromeoxidase (Complex IV)
    • Immediate Effect?
    • Ultimate Effect?
disrupting cellular respiration what happens if2
Disrupting cellular respiration:What happens if…..?
  • Rotenone
    • Binds to ubiquinone binding site of Complex I
    • Immediate Effect?
    • Ultimate Effect?
disrupting cellular respiration what happens if3
Disrupting cellular respiration:What happens if…..?
  • Dinitrophenol
    • Protonophore (makes membrane completely permeable to H+ ions)
    • Immediate Effect?
    • Ultimate Effect?
slide31

Anaerobic Respiration

(from wikipedia)

slide32

Homework Problem:

Question: The Glucose Problem

In the molecular process known as cellular respiration, how many ATP molecules can be made from the electron transport chain after one molecule of glucose is catabolized in glycolysis, pyruvate processing and the citric acid cycle.

Assume that 1 ATP is produced when 3.5 protons pass through ATP synthase.

**What pieces of information do I need to know to solve this problem?

slide34

Problem solving…

What would be the implications if a mitochondria was missing Complex II?

slide35

Problem solving…

If Complex I was missing, what would net more ATP: Krebs Cycle OR ETC?

slide36

Problem solving…

Can the ETC make energy (ATP) when we are not breathing? Why or why not?

slide37

Problem solving…

Assume there was an unlimited supply of readily available NADH and an unlimited supply of readily available photons. If you had to choose one of the below two processes to make ATP, which would you choose (and why!)

for tuesday
For TUESDAY:
  • SN5 and HW4 (Version 2.0)
  • Honors Option Students – SIGN UP FOR THE FIELD TRIP (and show me the money)