LB145 Sec 001-004. Happy Valentine’s Day!. Today’s Announcements. StudyNotes5 AND Homework4 are due on Tuesday Feb 19 th . **Download HW VERSION 2.0** Field Trip sign up – started! Glycolysis and the Krebs Cycle. Oxidative Phosphorylation, the ETC. Track the Carbons and Phosphates:
Happy Valentine’s Day!
Glucose + ATP Fructose-P + ADP
Fructose-P + ATP P-Fructose-P
P-Fructose-P P-CCC + P-CCC
P-CCC + P-CCC + 2NAD+ + 2Pi P-CCC-P + P-CCC-P + 2NADH
P-CCC-P + P-CCC-P + 2ADP P-CCC + P-CCC + 2ATP
P-CCC + P-CCC + 2ADP Pyruvate + Pyruvate + 2ATP
Glycolysis: What do you need to know?
GLYCOLYSIS & CITRIC ACID CYCLE
Substrate-level phosphorylation occurs when ATP is produced by the enzyme-catalyzed transfer of a phosphate group from an intermediate substrate to ADP.
via NADH and
+ 3 H+
Selling my Body to Science
Consume a cup of liquid glucose.
Consume capsules that contain bitter melon OR placebo.
Lie still on a bed with a dome over my head and allow breath to be analyzed for an hour.
Q1: On a molecular level, what is happening if bitter melon aids weight loss?
Q2: On a molecular level, what is happening if bitter melon does not aid weight loss?
Q3: Why were they interested in the air I exhaled?
Q4: What do you think might happen to excess glucose in your body?
Question: The Glucose Problem
In the molecular process known as cellular respiration, how many ATP molecules can be made from the electron transport chain after one molecule of glucose is catabolized in glycolysis, pyruvate processing and the citric acid cycle.
Assume that 1 ATP is produced when 3.5 protons pass through ATP synthase.
**What pieces of information do I need to know to solve this problem?
What would be the implications if a mitochondria was missing Complex II?
If Complex I was missing, what would net more ATP: Krebs Cycle OR ETC?
Can the ETC make energy (ATP) when we are not breathing? Why or why not?
Assume there was an unlimited supply of readily available NADH and an unlimited supply of readily available photons. If you had to choose one of the below two processes to make ATP, which would you choose (and why!)