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LIPOSOM. Agustina Setiawati. DEFINISI. Hydrophilic. Hydrophobic. Liposom adalah dimensi koloid berupa vesikel yang mempunyai struktur fosfolipid bilayer dan mempunyai muatan permukaan tertentu ( positif , negatif atau netral ). STRUKTUR UMUM. Classes of Liposomes. Conventiona l.

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liposom

LIPOSOM

AgustinaSetiawati

definisi
DEFINISI

Hydrophilic

Hydrophobic

Liposomadalahdimensikoloidberupavesikel yang mempunyaistrukturfosfolipidbilayerdanmempunyaimuatanpermukaantertentu (positif, negatifataunetral)

classes of liposomes
Classes of Liposomes
  • Conventional

Cationic

  • Immuno
slide5

Liposome kationik

Liposome anionik

Liposome non-ionik

Liposome Zwitterionik

Which one can form complexes with DNA?

kationik liposome
Kationik Liposome

Cationik liposome forms complex with DNA (negative charge)

Net charge of the complexes is positive so it can be interact to cell membrane

anionik liposom
AnionikLiposom

Can’t it deliver DNA? Yess

Mekanisme?

DNA tidakbisamembentukkompleksdgnliposomanionik (muatannegatif-negatif)

Supayabs, DNA dibuatkomplekslebihdahuludgnkation (Ca2+)

1995 liposome
1995 liposome

Cystic Fibrosis

  • Trials using liposome-mediated CFTR gene transfer began in 1995.
  • Non-viral vectors have the potential to avoid some of the critical problems observed with viral vectors, such as the immune response, limited packaging capacity, and random integration5 .
  • Liposomes may be mildly effective, but their activity does not last. For this approach to work, researchers need to figure out how to improve delivery, make the effects more permanent and reduce the adverse side effects.
  • To date, only cationic liposome-based systems have been tested in clinical trials in cystic fibrosis subjects6.
kelebihan
Kelebihan

Tidakmenimbulkanresponimunologis

Ukuran DNA yang dapatdibawaberagam

Modifikasilebihfleksibel

slide13

http://www.wellesley.edu/Biology/Courses/219/Gen_news/i3_Gene_Therapy.jpghttp://www.wellesley.edu/Biology/Courses/219/Gen_news/i3_Gene_Therapy.jpg