TUMOR MARKERS. Dr. Ismet M. Nur Sp.PA (K), MM. Dept. of Pathology Anatomy UNPAD / Hasan Sadikin Hospital Bandung. Tumor markers are :. Biochemical indicators of the presence of a tumor
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Dr. Ismet M. NurSp.PA (K), MM.
Dept. of Pathology Anatomy UNPAD/ HasanSadikin Hospital
Diagnosis of cancer
- keratin for carcinoma ( epithelial origin)
- desmin for neoplasm of muscle cell origin
- breast cancer : ER, PR, c-erbB2, p53
- ovarian cancer / endometrial cancer :
ER, PR, c-erbB2, BRCA1/ BRCA2
Molecular Diagnosis by
The predictive power of combined ER/PR phenotypes in patients with advanced/metastatic breast cancer receiving endocrine therapy (American Univ of Beirut) :Phenotype Incidence Response rateER+/PR+ 58% 77%ER+/PR- 23% 27%ER-/PR+ 4% 46%ER-/PR- 15% 11%