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Some stuff about cortical network modelling what I done. Richard Tomsett 1,2 , Miles Whittington 3 , Mark Cunningham 4 , Marcus Kaiser 2,4

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some stuff about cortical network modelling what i done

Some stuff about cortical network modelling what I done

Richard Tomsett1,2, Miles Whittington3,Mark Cunningham4, Marcus Kaiser2,4

Institute of Ageing and Health, Newcastle University2. School of Computing Science, Newcastle University3. Hull York Medical School, University of York4. Institute of Neuroscience, Newcastle University

OSB Hackathon, UCL, 6th November 2013

slide2

Matthew Ainsworth

OSB Hackathon, UCL, 6th November 2013

slide3

Matthew Ainsworth

OSB Hackathon, UCL, 6th November 2013

slide5

NB: wrong dimensions in Bush & Sejnowski 1993

OSB Hackathon, UCL, 6th November 2013

slide6

Thanks to:

  • Anna Simon
  • Mark Cunningham
  • Marcus Kaiser
  • BBSRC, Wellcome Trust

OSB Hackathon, UCL, 6th November 2013

slide9

LFP simulation

100um – 1000um

OSB Hackathon, UCL, 6th November 2013

slide10

LFP simulation

OSB Hackathon, UCL, 6th November 2013

slide11

LFP simulation

100um – 1000um

OSB Hackathon, UCL, 6th November 2013

slide12

LFP simulation

Edge Half-way to gamma generating region

OSB Hackathon, UCL, 6th November 2013

slide13

LFP simulation

100um – 1000um

OSB Hackathon, UCL, 6th November 2013

slide14

LFP simulation

Top Middle Bottom

OSB Hackathon, UCL, 6th November 2013

slide15

Kawaguchi & Kondo, 2002

OSB Hackathon, UCL, 6th November 2013

slide16

“Regular spiking non pyramidal cell”

GABAA

GABAA

Bitufted cell

GABAA

+GABAB

Neurogliaform cell

Basket cell

GABAA

GABAA

Axo-axonic cell

Pyramidal cell

Slide courtesy of Anna Simon

slide17

GABAA

Other interneurons

?

Basket cell

Pyramidal cell

slide18

90% basket cell reduction in central 2mm section, replaced by non-basket interneurons (regular spiking)

OSB Hackathon, UCL, 6th November 2013

slide19

Thanks to:

  • - Matt Ainsworth (York)
  • Anna Simon (Newcastle)
  • Mark Cunningham (Newcastle)
  • Miles Whittington (York)
  • Marcus Kaiser (Newcastle)
  • BBSRC, EPSRC, Wellcome Trust

OSB Hackathon, UCL, 6th November 2013