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NBC2 Builds the Biomanufacturing Infrastructure for the Bioeconomy. Sonia Wallman Executive Director NBC2. What is Biomanufacturing ?. “Biomanufacturing… It is about 21 st century advanced technology manufacturing inside living cells” -NSF Proposal 0903208. NBC2 Hub Partners.
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Sonia WallmanExecutive DirectorNBC2
“Biomanufacturing… It is about 21st century advanced technology manufacturing inside living cells”
-NSF Proposal 0903208
Metrology: SOPs for Equipment
Quality Assurance: cGMP, SOPs, Batch Records, Equipment Logs
Quality Control Microbiology SOPs
Upstream Processing SOPs:
E. coli recombinant for GFP, CHO recombinant for tPA Cell Culture,
Pichia pastoris recombinant for HSA Cell Culture
Downstream Processing SOPs: Purification of human tPA from CHO Cell Culture
Purification of human serum albumin from Pichia pastoris Cell Culture
Quality Control Biochemistry SOPs: SDS-PAGE, tPA and HSA ELISAs
Marti Mathews, Biogen Idec
Brian Shingle, Centocor
Gene Kernan, HGSI
Patrick Sheehy, HGSI
John Piampiano, Kodak
Olga Mollin, Lonza
Jane Flanagan, Lonza
Paul O’Neil, Pall Euroflow
Ezster Birck Wilson
Can be found at: www.biomanonline.org
Joe was an apprentice at Lonza in the first year of his Biotechnology Associate’s degree from GBCC in 2008. With 12 credits transferred in from college classes taken in high school (Running Start), he graduated early and worked at Lonza prior to attending UMBC this Fall 2009.
Virtual Chromatography – The Power of Interactive Visualization in Understanding a STEM Field of Study
A screenshot of the Virtual Liquid Chromatography Laboratory.
3D images of major system components are delivered as you click on them.
The Virtual Liquid Chromatography Laboratory showing the interactive controller which
enables students to operate the system and set process parameters.
The Virtual Chromatography Laboratory teaches students how to make calculations on chromatograms such as the efficiency of column packing (HETP).
The Virtual Chromatography Laboratory showing the operation of the chromatography system during the ‘load’ phase, the chromatogram showing the flow through of proteins that do not attach to the chromatographic matrix, and a nanoscale view inside the column of the affinity bead with the protein of interest in the filtrate (green) attached and proteins not specific for the bead flowing through the column.
The Virtual Chromatography Laboratory showing the operation of the chromatography system during the ‘elution’ phase, the chromatogram showing the beginning of the peak of the protein of interest, and a nanoscale view inside the column of the affinity bead showing the protein of interest detaching from the bead as the elution buffer (red) moves through the column.
Photo Bubble Bioreactor
Biohydrogen from Bacteria
Making tPA in CHO Cells
Five Days/Five Topics
Online support at www.biomanonline.org
Total number = 103 teachers
Career and Technical HS
QC Biochemistry – SDS PAGE
Total number = 71 teachers
GFP Column Chromatorgraphy
at Blue Grass CTC
Alltech Tour: The Future Farm