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ANEMIA

ANEMIA. DEFINISI : Hb Ht < NORMAL -  INDIVIDU Eri TSB KLASIFIKASI : - PATOGENESIS - MORFOLOGIS - ERITROKINETIK. KLASIFIKASI. SST. Bahan : Fe Folid Acid Vit B12 Protein.

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ANEMIA

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  1. ANEMIA • DEFINISI : Hb Ht < NORMAL - INDIVIDU Eri TSB KLASIFIKASI : - PATOGENESIS - MORFOLOGIS - ERITROKINETIK

  2. KLASIFIKASI SST Bahan : Fe Folid Acid Vit B12 Protein OUTPUT Perdarahan Hipoplasi

  3. ANEMIA HEMOLITIK • DEFINISI : HEMOLITIK BERLEBIHAN KOMPENSASI S.S.T -> N • KLASIFIKASI BERDASARKAN : - KLINIS - LOKALISASI - HEREDITER/DIDAPAT - ETIOLOGI

  4. (LANJUTAN) • KLINIS : AKUT/KRONIS • LOKALISASI : - INTRA-KORPUSKULER : - ENZIM - HEMOGLOBIN - MEMBRAN - EKSTRA-KORPUSKULER : - A.I.H.A - TRANSFUSI YANG SALAH

  5. MANIFESTASI KLINIK • GEJALA ANEMIA • GEJALA HEMOLITIK • KELAINAN LABORATORIUM : - TANDA HEMOLITIK MENINGKAT - TANDA PENINGKATAN ERITRO POESIS - TANDA KHAS PENYAKIT

  6. MANIFESTASI KLINIK • TERGANTUNG KEPADA : - DERAJAT BERKURANG KAPASITAS MEMBAWA O.2 - DERAJAT BERKURANG VOL DARAH - PENYAKIT DASARNYA - KEMAMPUAN KOMPENSASI SIST KARDIOVASKULER

  7. MANIFESTASI KLINIK • SISTEM KARDIOVASKULER • KULIT DAN SEL LENDIR • SISTEM NEUROMUSKULER • SISTEM PENCERNAAN • SISTEM UROGENITAL • SISTEM METABOLIK

  8. Manifestasi klinik Hemolitik • Demam, bisa samopai menggigil • Sakit pinggang • Sklera sub-ikterik • Splenomegali • Pemeriksaan laboratorium - Anemia - Darah tepi : poikilositosis, anisositosis, polikromasi - Hiperbilirubinemia ( Bil I meningkat) - Ferritin meningkat • Sumsum tulang hiperaktif

  9. Pemeriksaan laboratorium • Anemia • Retikulositosis • Darah tepi : poikilositosis, anisositosis, polikromasi sel target • Hiperbilirubinemia ( Bil I meningkat) • Ferritin meningkat • Sumsum tulang hiperaktif

  10. PENGOBATAN • KAUSAL • TRANSFUSI DARAH • KORTIKOSTEROID • SPLENEKTOMI

  11. ANEMIA HEMOLOTIK OTO-IMUN • PATOFISIOLOGI AUTO-AG ------------ AUTOAB AG-AB KOMPLEKS HEMOLISIS ERITROSIT ANEMIA

  12. DIAGNOSIS • GEJALA KLINIS HEMOLITIK • LABORATORIUM - COOM ’ S TEST COLD ANTIBODI WARM ANTIBODI

  13. PENGOBATAN • IMUNOSUPRESIF : - KORTIKOSTEROID - SIKLOSPORINE - SIKLOFOSFAMIDE 2. IMUNOGLOBULIN • SITOKINE : INTERFERON ALFA • LAIN-LAIN : VAKSINASI LIMFOID

  14. ANEMIA POST-HEMORHAGIK • KLASIFIKASI : - AKUT ---- NORM NORMOKROM - KRONIK ---- MIKROS MIKROHIPOKROM • ETIOLOGI : - AKUT : PERDARAHAN AKUT : TRAUMA OPERASI -

  15. (LANJUTAN) - PERDARAHAN KRONIS ANKILOSTOMIASIS GASTRITIS KRONIS ULKUS PEPTIKUM KOLITIS ULSERATIF MIOMA UTERI

  16. Pengobatan • Etiologi • simptomatik

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