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Biological Membranes. Penghui Lin Nov. 15. 2013. Membranes. http://www.uvm.edu/~inquiryb/webquest/fa06/mvogenbe/. Diffusion across plasma membrane. http://en.wikipedia.org/wiki/Cell_membrane. Plasma Membrane.

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biological membranes

Biological Membranes

Penghui Lin

Nov. 15. 2013

membranes
Membranes

http://www.uvm.edu/~inquiryb/webquest/fa06/mvogenbe/

diffusion across plasma membrane
Diffusion across plasma membrane

http://en.wikipedia.org/wiki/Cell_membrane

plasma membrane
Plasma Membrane

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

man made membrane
Man-made membrane

http://bioweb.wku.edu/courses/biol115/wyatt/biochem/lipid/Lipid_2.asp

liquid crystals
Liquid crystals
  • Nematic phase
  • Smecticphases
  • Chiral phases

http://en.wikipedia.org/wiki/Liquid_crystal

sample preparation
Sample preparation

Jörg Fitter, Thomas Gutberlet, John Katsaras. Neutron Scattering in Biology, Techniques and Applications. 2006ISBN: 978-3-540-29108-4 (Print) 978-3-540-29111-4 (Online)

specular neutron reflectivity
Specular Neutron Reflectivity

Incident angle = reflected angle

Jörg Fitter, Thomas Gutberlet, John Katsaras. Neutron Scattering in Biology, Techniques and Applications. 2006ISBN: 978-3-540-29108-4 (Print) 978-3-540-29111-4 (Online)

density profile 0 z
Density profile ρ0(z)

Fourier Synthesis

Jörg Fitter, Thomas Gutberlet, John Katsaras. Neutron Scattering in Biology, Techniques and Applications. 2006ISBN: 978-3-540-29108-4 (Print) 978-3-540-29111-4 (Online)

location of cholesterol
Location of Cholesterol

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

location of cholesterol1
Location of cholesterol

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

forces between membranes
Forces between membranes

Osmotic pressure

Disjoining pressure

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

osmotic stress experiment
Osmotic stress experiment

Neutron/

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

thermal unbinding
Thermal unbinding

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

single component membrane
Single component membrane

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

lipid mixtures and domains
Lipid mixtures and domains
  • Ideal mixing: no phase separation
  • Non-ideal or non-random mixing: compositional fluctuation happens while no stable domains formed
  • Macroscopic phase separation: micron-size stable lipid domains are formed
no phase separation
No phase separation

Membrane

thickness

Fluctuation

parameter

in DMPC bilayers at 35°

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

macroscopic phase separation
Macroscopic phase separation

DPPC/DOPC/cholesterol

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

supramolecular properties
Supramolecular properties

Tilted phase

Interdigitated phase

Diffused scattering

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

bicelle mixtures
Bicelle mixtures

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

bicelle mixtures1
Bicelle mixtures

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

fluctuation change upon antimicrobial peptide binding
Fluctuation change upon antimicrobial peptide binding

Jörg Fitter, Thomas Gutberlet, John Katsaras. Neutron Scattering in Biology, Techniques and Applications. 2006ISBN: 978-3-540-29108-4 (Print) 978-3-540-29111-4 (Online)

membrane rigidity change
Membrane rigidity change

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

slide25

Pabst G. Applications of neutron and X-ray scattering to the study of biologically relevant model membranes J.ChemPhys Lipids. 2010 Jun;163(6):460-79

thanks

Thanks!

Jörg Fitter, Thomas Gutberlet, John Katsaras. Neutron Scattering in Biology, Techniques and Applications. 2006ISBN: 978-3-540-29108-4 (Print) 978-3-540-29111-4 (Online)