Age-related serum PSA levels among public servants without prostate cancer in Lagos

1. Age-related serum PSA levels among public servants without prostate cancer in Lagos S. Odunayo Ikuerowo FWACS (Urol) Senior Lecturer and Consultant Urologist Lagos State University College of Medicine and Teaching Hospital Ikeja, Lagos, Nigeria

2. Introduction • Serum prostate-specific antigen (PSA) levels increase with age • Varies among different races and communities • The true age-specific range in our community is not known • The study was aimed at defining the age-specific reference ranges of serum PSA in our environment.

3. Methods • We evaluated the relationship between age and serum PSA level • The age-specific reference ranges of serum PSA • Among civil servants in Lagos who underwent routine annual medical checkups • Criteria for inclusion • men who have no lower urinary tract symptoms • normal digital rectal examination • serum PSA ≤20ng/ml. • Age ≥40 and ≤70 years • SPSS Statistic 21 was used for data evaluation • Mean, median, 95th percentile PSA levels were estimated. • Pearson’s correlation was used to examine the relationship • p<0.05 was considered significant.

4. Results • 4032 out of 7105 men met the criteria for inclusion in the evaluation • The mean age was 51.6 (range 40 – 70) years • Strong correlation between serum PSA levels and age (r=0.097, p<0.001

9. Conclusions • The age-specific PSA levels among Nigerian men for each age group is higher than what was described by Oesterling for men in the Western world • These reference ranges of serum PSA may be considered for men aged ≥40 years in our environment.

10. THANK YOU