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Course outline

Course outline. Introduction. Benefits of microsystems. Cost savings Mass production Simplification of structures and machines Less materials Reduced reagent consumption Lower power consumption. Benefits of microsystems. Reduction of size Portable devices Lab-on-a-chip

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Course outline

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  1. Course outline

  2. Introduction

  3. Benefits of microsystems Cost savings • Mass production • Simplification of structures and machines • Less materials • Reduced reagent consumption • Lower power consumption

  4. Benefits of microsystems • Reduction of size • Portable devices • Lab-on-a-chip • Faster processes • Enhanced safety

  5. A very short history Microfluidic chip test tubes flask

  6. Microfluidics sizes a drop a channel 100 μl 50x50 μm2 x 4000 cm

  7. Microfluidics background Microfluidic devices • Micropumps • Microvalves • Micromixers • etc. Microfluidic systems • Chemical analysers • Drug delivery systems • etc.

  8. Microfluidics background • Fluid flow is laminar • No turbulent mixing • Mixing is by diffusion • High electric fields in micro-channels are possible

  9. Laminar flow • Whether flow will be laminar can be determined from the Reynolds number • When Re < 2300, flow is always laminar • When Re > 2300, flow can be turbulent

  10. Laminar flow

  11. Laminar flow

  12. Laminar flow Passive mixer introduce bends, surface texturing

  13. Laminar flow Active mixer pump

  14. Pressure switch Zhao et al., Science 249, February 9 2001

  15. Pattern creation

  16. Pattern creation

  17. Fabrication

  18. PDMS making

  19. PDMS making

  20. Hole making

  21. Hole making

  22. Cleaning

  23. Pumping

  24. Microsystem set-up

  25. Microsystem set-up

  26. Fluidic interface

  27. Control

  28. Control

  29. DNA computing

  30. Beads with DNA

  31. Beads filling

  32. Beads in microreactors

  33. Hybridisation

  34. DNA hybridisation

  35. DNA hybridisation intensity [a.u.] time [3s] micro pico femto

  36. A complete DNA computer 3.5mm

  37. Application

  38. Fluidic logic • In 1950’s, there was a push research in this area for control systems resistant to radiation, temperature, and shock. • Examples of fluidic logic components:

  39. Fluidic logic

  40. Fluidic logic

  41. Fluidic logic

  42. Fluidic logic

  43. FPGA • Evolved configuration showing routing, LUT contents, and simulated fault. Inputs are on the lines labeled MSB and LSB, referring to the least/most significant bit of the input. Wires that are shown crossing perpendicularly (eg, +) are unconnected - only wires that have > junctions are connected

  44. FPGA

  45. FPGA

  46. Microfluidic logic Quake et al., 2002

  47. Microfluidic logic Quake et al., 2002

  48. BioMEMS

  49. BioMEMS Aclara Biosciences LabCard microfluidics system

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