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Resistance mutations in drug-naïve HIV-1 infected pregnant women and their children(after sdNVP ) in China. Jianfeng Han China Center for Disease Control and Prevention 2010-07-19. Background Methods and population Results Conclusion.

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Resistance mutations in drug-naïve HIV-1 infected pregnant women and their children(after sdNVP) in China

Jianfeng Han

China Center for Disease Control and Prevention

2010-07-19

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Background

Methods and population

Results

Conclusion

slide3
Background

Resistance mutations in drug-naïve HIV-1 infected pregnant women and their children(after sdNVP) had not been studied in China before.

We made a cross-sectional study of the resistance information in China.

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Methods and population

165 drug-naïve HIV-1 infected pregnant women

(blood samples, 36-week gestation, four provinces)

Their matched children

(DBS samples, 1 month postpartum)

Mothers and infants had taken sdNVP for PMTCT at intrapartum

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Results-women

138 baseline samples of women were amplified successfully(83.6%, 138/165)

Primary resistance mutations were detected in 14 pregnant women (10.1% ,14/138)

NRTI and NNRTI mutations, no PI major mutations

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Results-women

The subtype of Henan, Guangxi, Xinjiang province was subtype B', CRF 01AE, CRF 07BC respectively.

The subtypes in women from Yunnan province were most diverse

Proportion of recent infections in positive pregnant women: 10.9%(18/165).

Viral-load, CD4 cell counts did not have a good correlation with baseline resistance.

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Results-children

24 (14.5%, 24/165) children got infected with HIV and 9 children harbored resistance mutations(37.5%, 9/24).

6 children developed resistance mutations due to administration of sdNVP and 3 inherited resistance mutations from their mothers.

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Conclusions
  • NRTI and NNRTI resistance mutations were most common in HIV-1 infected pregnant women.
  • Relative high prevalence of drug resistance in them and their children underscored the necessity for resistance testing to guide PMTCT and subsequent therapy.