1 / 22

BIOKIMIA ENDOKRIN dr.Syazili Mustofa . Departemen Biokimia Kedokteran UN IVERSITAS LAMPUNG

BIOKIMIA ENDOKRIN dr.Syazili Mustofa . Departemen Biokimia Kedokteran UN IVERSITAS LAMPUNG. Kenapa penting??. Dasar untuk mempelajari penyakit gangguan endokrin. Gangguan endokrin yang sering ditemui adalah: Diabetes melitus Hipertiroidisme. Mechanism of Hormone Action.

tatum
Download Presentation

BIOKIMIA ENDOKRIN dr.Syazili Mustofa . Departemen Biokimia Kedokteran UN IVERSITAS LAMPUNG

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. BIOKIMIA ENDOKRINdr.Syazili Mustofa.DepartemenBiokimiaKedokteranUNIVERSITAS LAMPUNG

  2. Kenapa penting?? Dasar untuk mempelajari penyakit gangguan endokrin. Gangguan endokrin yang sering ditemui adalah: • Diabetes melitus • Hipertiroidisme

  3. Mechanism of Hormone Action • Hormones are carried by the blood, yet they affect only certain cells. The specific cells that respond to a given hormone have receptor sites for that hormone. • Receptor sites may be located on the surface of the cell membrane or in the interior of the cell.

  4. SISTEM HORMON Hormon = membangkitkan aktivitas • Hormon oleh jar. → sistem sirkulasi → jar. Lain • Parakrin → organ sama jaringan berbeda • Autokrin →organ dan jaringan yg sama Hormon dapat ditargetkan pada lebih dari satu jaringan . Kelenjar target: • ± 200 tipe sel tubuh • ± 50 hormon yang sudah dikenal

  5. Reseptor Hormon Ada dua macam reseptor hormon: 1.Reseptor yang mengikat hormon di luar sel. Hormon polipeptida, protein, dan katekolamin terikat reseptor pada membran plasma → menyalur fungsi ke intrasel melalui aktivitas enzim adenilil siklase  cAMP dan fosfolipase C  Ca++ 2.Reseptor yang mengikat hormon intraselluler Hormon Steroid dan Tiroid,  Transkripsi

  6. Mechanism of Hormone Action • Protein hormones, in general, are water soluble and are unable to diffuse through the cell membrane and react with receptor sites on the surface of the cell. • Steroids are fat soluble and can diffuse through the cell membrane and react with receptors inside the cell.

  7. Mechanism of Hormone Action

  8. Mechanism of Hormone Action

  9. Mekanisme Kerja Insulin

  10. Mekanisme Kerja Insulin

  11. Mekanisme Kerja Insulin

  12. HORMON RESEPTOR MEMBRAN; • ACTH • ADH • FSH • hcG • LIPOPROTEIN = LPH • LUTEINISASI = LH • TSH • PARATIROID (PTH) • GLUKAGON • INSULIN • ADRENALIN DAN NOR ADRENALIN

  13. Mechanism of steroid Hormone Action

  14. Mechanism of steroid Hormone Action

  15. HORMON RESEPTOR INTRASEL: • ESTROGEN • GLUKOKORTIKOID • MINERALOKORTIKOID • PROGESTIN • KALSITRIOL • ANDROGEN • TIROID = T4;T3

More Related