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Cutting-Edge Research Priorities in Degeneracy and Library Design for Genetic Engineering

Explore innovative methods such as partially randomized libraries and single site scans for gene manipulation. Develop new designs for targeting disease genes and Anopheles. Benchmark expression and stability of HEGs.

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Cutting-Edge Research Priorities in Degeneracy and Library Design for Genetic Engineering

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  1. 2009 research priorities • Cleavage degeneracy • partially randomized libraries in vitro Cre, Mso, mCre, mMso (Hui) • single site scans by recombination induction in vivo (Umut, Hui) • end capture from genomic DNA/Solexa sequence (Stefan) • insertion site tagging/sequencing (Stefan w/H-P’s lab,Byoung). • New designs for disease gene/Anopheles targets (Umut) • More active/’up’ mutant versions of Mso (Hui) • Benchmarking of native/engineered HEG’s • - expression/stability/toxicity as f(activity)/in vivo sites above (Stefan)

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