Transcription in E.coli by the numbers. Size of typical gene = 1kb Typical number of mRNAs = 10 Typical rate of mRNA production = 10 min -1 Typical mRNA degradation rate = 1 min -1. mRNA production in E.coli. Golding et al. ‘05. r=1/7min ° =ln2/50min.
Golding et al. ‘05
Master equation for p(m,t):
var(m) = 4 <m>
Poisson: var(m) = <m>
Inconsistent with unregulated transcription model
Transcription occurs in bursts!
Gardner, Cantor and Collins ‘00
Elowitz and Leibler ‘00
What is the distribution
of people per square?