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Cytokines

Cytokines. Slackers Facts by Mike Ori. Disclaimer. The information represents my understanding only so errors and omissions are probably rampant. It has not been vetted or reviewed by faculty. The source is our class notes.

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Cytokines

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  1. Cytokines Slackers Facts by Mike Ori

  2. Disclaimer The information represents my understanding only so errors and omissions are probably rampant. It has not been vetted or reviewed by faculty. The source is our class notes. The document can mostly be used forward and backward. I tried to mark questionable stuff with (?). If you want it to look pretty, steal some crayons and go to town. Finally… If you’re a gunner, buck up and do your own work.

  3. IL-1 Secretor

  4. Macrophage

  5. IL-1 effects

  6. Pyrogenic Acute inflammatory signal

  7. IL-2 Secretor

  8. Activated T helpers

  9. IL-2 effects

  10. Growth of T helpers and cytotoxic T’s

  11. IL-3 secretor

  12. Activated T cells

  13. IL-3 effects

  14. Stem cell growth in marrow similar to GM-GSF

  15. IL-4 Secretor

  16. TH2 cells Mast cells

  17. IL-4 effects

  18. Growth of B cells Ig class switching

  19. IL-5 Secretor

  20. TH2 cells Mast cells

  21. IL-5 Function

  22. B cell differentiation IgA class switch (notes have IgG1) Eosinophil production and activation

  23. IL-6 Secretor

  24. T helpers and macrophages

  25. Il-6 function

  26. Stimulates acute phase reactants and Ig

  27. IL-7 Secretor

  28. Thymic and bone marrow stromal cells

  29. IL-7 function

  30. Survival signal for immature T and B cells

  31. IL-8 secretor

  32. Macrophages

  33. IL-8 Function

  34. Major neutrophil chemotactic factor

  35. IL-10 Secretor

  36. T reg NOTE: Table in notes is different. See Mechanisms of immunity 12.

  37. IL-10 function

  38. Inhibits activated T cells

  39. IL-12 secretor

  40. B cells and macrophages

  41. IL-12 function

  42. Activates TH1 cells and NK cells

  43. IL-13 Secretor

  44. TH2 cells

  45. Il-13 Function

  46. Stimulates allergic response

  47. IFN-gamma Secretor

  48. TH1 cells

  49. IFN-gamma function

  50. Activates macrophages

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