Prions. Alicia Arguelles, Jerry Wang May 4, 2007. What are prions?. pr oteinaceous i nfectious particle an infectious agent made only of protein, containing no nucleic acids The PRNP gene encodes for the prion protein (PrP) PrP is active in the brain and several other tissues
Alicia Arguelles, Jerry Wang
May 4, 2007
We all know that proteins normally are digested down to amino acids in the gut, and transported through the gut epithelium by amino acid transporters. Well if Prions took this route they would not longer be infectious, so…
We already know that Prions are extremely resistant to degradation so they are not broken down and digested.
Even so, they should not be absorbed across the intestinal wall, right?
In fact, they circumvent the normal process of intestinal absorption by passing into the Gut-Associated Lymphoid Tissue (GALT). Related to this, it seems that chronic inflammation predisposes to prion infectivity, e.g. in rheumatoid arthritis, type-I diabetes, or Crohn’s disease.How Prions Access the Brain..
An epidemic in Brittish cattle occurred when farmers started to use animal by-product as the main source of feed for their cattle.
This lead to an over all higher rate of infection and disease.Bovine spongiform encephalopathy(BSE) mad cow disease
Pharmaceutical Biotechnology 2005. 6: 167-177