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Impact of BaP and BPDE on Viability in HCT116 p53-WT and p53-null Cells

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This study examines the effects of Benzo[a]pyrene (BaP) and Benzo[a]pyrene diol epoxide (BPDE) on the viability of HCT116 cells with wild-type (p53-WT) and null (p53-null) p53 status. Cells were treated with up to 5 µM BaP or 1 µM BPDE and assessed for viability after specified exposure times. Control cells were treated with DMSO and deemed 100% viable. The results reflect the mean and range from two independent experiments, demonstrating the differential responses of p53-WT and p53-null cells to these compounds.

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Impact of BaP and BPDE on Viability in HCT116 p53-WT and p53-null Cells

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  1. A B p53-WT p53-null Viable cells (% control) Viable cells (% control) C D BaP (mM) BaP (mM) Viable cells (% control) Viable cells (% control) BPDE (mM) BPDE (mM) Supplementary Figure 2. HCT116 p53-WT (A, C) and p53-null (B, D) cells were treated with up to 5 M BaP (A, B) or 1 µM BPDE (C, D) and harvested after the indicated exposure times for cell viability analysis. Control cells treated with DMSO were taken to be 100% viable and from this percentage viability was calculated for exposed cells. Values are the mean  range of the two independent experiments.

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