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HP DNA

HP DNA. Highly Polymerized Deoxyribonucleic Acid. HP DNA. Highly Polymerized Deoxyribonucleic Acid. Definition. Marine Biopolymer characterized by. Its source. Its special method of extraction. Its determined physico-chimical properties. HP DNA. Highly Polymerized Deoxyribonucleic Acid.

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HP DNA

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  1. HP DNA Highly Polymerized Deoxyribonucleic Acid

  2. HP DNA Highly Polymerized Deoxyribonucleic Acid Definition Marine Biopolymer characterized by Its source Its special method of extraction Its determined physico-chimical properties

  3. HP DNA Highly Polymerized Deoxyribonucleic Acid Origin Natural hydrosoluble substance extracted from the milt of wild salmon By non-denaturating technology • protecting the superstructure of polymer • preserving its physiological activity

  4. HP DNA Highly Polymerized Deoxyribonucleic Acid Aspect White-cream fibers measuring several centimeters

  5. HP DNA Highly Polymerized Deoxyribonucleic Acid Solubility Relatively soluble in water Making a gel with low concentration (1.0 to 3.0 %) insoluble in • alcohol • ethanol • the other oganic solvents

  6. HP DNA Highly Polymerized Deoxyribonucleic Acid Metabolism • half-life of 72 hours at rat • elimination after 96 hours:fecal (62,8 %) and urinary (19,4 %) • hepatic degradation in mononucleotides • biliary elimination • the intestine seems to retain polymerized parts of DNA and to be rapidly saturated in part of low molecular weight • the lymphatic tissue seems to accumulate polymerized parts of DNA then to release them rapidly in venous blood

  7. HP DNA Highly Polymerized Deoxyribonucleic Acid Pharmacovigilance Followed by laboratory Sterlin-Winthrop from 1985 and 1990 • administration almost without secondary effects • excellent clinical tolerance (superior to 90 %)

  8. HP DNA • Highly Polymerized Deoxyribonucleic Acid Antioxidant Properties (1) • It retards and diminishes the formation of dienes conjuges (joined paired),notably by its antiradical activity vis-à-vis the hydroxyl radical (OH°–)

  9. HP DNA • Highly Polymerized Deoxyribonucleic Acid Antioxidant Properties (2) •The capturing of this highly reactive radical by HP DNA accompanies the formation of a stable product, the 8-hydroxy-guanosine (8-OHDG), and avoids the formation of a new free radical and thus terminates the process of peroxydation. => HP DNA protects the cells against extra cellular oxidative aggressions.

  10. HP DNA Highly Polymerized Deoxyribonucleic Acid Antioxidant Properties (3) • protector effect against lipoperoxydation

  11. HP DNA Highly Polymerized Deoxyribonucleic Acid Antioxidant Properties (4)

  12. HP DNA • Highly Polymerized Deoxyribonucleic Acid Anti-asthenia effect(1) Open clinical study : HP DNA 8OO mg/j during 30 days • 44 asthenic adults (having no less than 15 of the 60 asthenia symptoms present) compared to 32 normal adults (having less than 15 of the 60 asthenia symptoms present) •  62.7 % of the physical asthenic symptoms •  40 % of the mental asthenic symptoms • The scores observed in the treated asthenic patients directly approached those patients seen as normal •  58 of 60 of asthenia symptoms •  many of the most debilitating symptoms • action on asthenia by HP DNA globally is positive in 52.4% of the cases

  13. HP DNA • Highly Polymerized Deoxyribonucleic Acid Anti-asthenia effect (2) Open multi-centered study: HP DNA 800 mg/day during 15days • 688 adults (445 women and 243 men) •spontaneous asthenia showed during the interrogation/isolated or associated with a non evolutionary benign organic pathology Treatment by HP DNA: •  Behaviour Rating Scale (61 criteria) - 64.5 % for physical asthenia, - 57.0 % for mental asthenia • improvements more intensively marked when more severe symptoms • global efficacy of the treatment evaluated by researchers in 79.1% of the cases

  14. HP DNA • Highly Polymerized Deoxyribonucleic Acid Anti-asthenia effect (3) Amélioration de l’asthénie physique

  15. HP DNA • Highly Polymerized Deoxyribonucleic Acid Anti-asthenia effect (4) Improvement of psychic asthenia

  16. HP DNA • Highly Polymerized Deoxyribonucleic Acid Anti-asthenia effect (5) Open study • HP DNA 400 mg/day +ascorbic acid 1 g/day during 15 days • 6876 patients Patients did not receive another anti-asthenia treatment (70 % of cases) •  fatigue at night (a reduction of more than 50% of the intense symptoms) in 82.5 % of cases •  fatigue in the morning in 82.9 % of cases •  difficulty concentrating in 76.9 % of cases •  trouble sleeping in 75 % of cases •  trouble with appetite in 80 % of cases

  17. HP DNA • Highly Polymerized Deoxyribonucleic Acid Anti-asthenia effect (6)

  18. HP DNA • Highly Polymerized Deoxyribonucleic Acid Anti-asthenia effect (7) Open clinical trial : ADN-HP 800 mg/day during 1 month • 24 persons of more than 50 years with asthenia of which 16 had anorexia and 8 were chronic alcoholics

  19. HP DNA • Highly Polymerized Deoxyribonucleic Acid Anti-asthenia effect (8) Treatment by HP DNA •  patients general state in 70 % of cases and  mental state in 63% of cases

  20. HP DNA • Highly Polymerized Deoxyribonucleic Acid Effect on basic arthralgies (1) Multicentric clinical study, in a double blind • 116 patients suffering from chronic spinal problems (for a period of more than 1 month) • HP DNA 800 mg/day during 30 days versus placebo Treatement by HP DNA •  43.6 % intensity of the pain, quantified on the numeric scale of Huskinson (versus 25.4 % with placebo) •  32.6 % degree of functional discomfort (handicap) (versus 25.4 % with placebo)  •  43. 3 % importance of the limitation of passive mobilization of the spine (versus 26.9 % with placebo)

  21. HP DNA • Highly Polymerized Deoxyribonucleic Acid Effect on basic arthralgies (2)

  22. HP DNA • Highly Polymerized Deoxyribonucleic Acid Chondrostimulating activity (1) Open study • 2960 persons affected by arthrosis, with an average age of 61.1 years old • ADN-HP 400 mg/day + complex of vitamins (B + E) • during 1 or 2 months Treatment by HP DNA • at the end of the first month of treatment:  pains in 89.5 % of cases – 21 % were completely relieved – 68.5 % were partially relieved  physical performance in 83.6 % of cases

  23. HP DNA • Highly Polymerized Deoxyribonucleic Acid Chondrostimulating activity (2)

  24. HP DNA • Highly Polymerized Deoxyribonucleic Acid Chondrostimulating activity (3) In double blind study • 67 persons affected by arthrosis with average disability of the knees and hips • HP DNA 400 mg/day + complex of vitamins (B + E) • versus diclofénac (anti-inflamatory, non-steroid) • during 42 days

  25. HP DNA • Highly Polymerized Deoxyribonucleic Acid Chondrostimulating activity (4) Treatment by HP DNA •  39 % pain (versus 35 % with diclofénac)

  26. HP DNA Highly Polymerized Deoxyribonucleic Acid Chondrostimulating activity (5) Treatment by HP DNA •  16.1 % degree of impotence (versus 26,1 % with diclofénac)

  27. HP DNA • Highly Polymerized Deoxyribonucleic Acid Consolidation of dental joints (1) Study : with a traditional local method • 108 patients affected by periodontal pathology, • HP DNA 1600 mg/day during 3 months With administration of HP DNA •  the index of dental mobility to a high of 45.7% •  ………………………… to a low of 22.5%

  28. HP DNA • Highly Polymerized Deoxyribonucleic Acid Consolidation of dental joints (2) Success treatment for : • 56 % of patients treated by HP DNA and local treatment • 7 % only of patients treated with a traditional local method

  29. HP DNA • Highly Polymerized Deoxyribonucleic Acid Effect on physical performance (1) Study on mice • HP DNA 200mg/day + ascorbic acid 500 mg/day during 5 days => amelioration of a swimming test

  30. HP DNA • Highly Polymerized Deoxyribonucleic Acid Effect on physical performance (2) Study on dog • HP DNA 400 mg/day ± ascorbic acid 1 g/day • before standard exertion •  50 % the frequency of heart exertion with HP DNA+ vit. C •  the recuperation time after exertion: – 50 % with HP DNA alone – 83 % with HP DNA + vitamin C •  elevation of cortisolemie 50 minutes after exertion: – 71% with HP DNA alone – 100 % with HP DNA + vitamin C

  31. HP DNA • Highly Polymerized Deoxyribonucleic Acid Effect on physical performance (3) Study on men • 30 athletes with an average age of 20 years old • HP DNA 800 mg/day + vitamin C 2000 mg/day during 21 days

  32. HP DNA • Highly Polymerized Deoxyribonucleic Acid Effect on physical performance (4) Effect of the association (1) •  recuperation index, calculated by the Ruffier-Dickson Test

  33. HP DNA • Highly Polymerized Deoxyribonucleic Acid Effect on physical performance (5) Effect of the association (2) •  maximum oxygen intake (VO2 max) evaluated using the Cooper test

  34. HP DNA • Highly Polymerized Deoxyribonucleic Acid Regenerative action on intellectual development in regard to psychomotor and biometrics of subjects with mental defects Double blind study: HP DNA 200 - 600 mg/day versus placebo during 3 months 256 children between the ages of 6 and 21 years with average to profound mental defects The children have benefited by gaining mental age in cases of: • Exogenous defects with an IQ* > 40 • A real age understanding of between 8 and 14 years * intellectual quotient

  35. HP DNA • Highly Polymerized Deoxyribonucleic Acid Immunostimulating activity (1) In mice without spleens 4 weeks before, when injected intra-peratonial 0.03 to 0.3 g/kg with HP DNA for 10 days •  resistance vis-à-vis a parasitic infection ( time augmented for surveying the animal traits with regard to the evidence) •  capacity of the lymphocytes to divide and produce interleukine 2 In vitro, HP DNA exerted a mitogene effect on the splenocytes of naturally immune-depressed mice.

  36. HP DNA • Highly Polymerized Deoxyribonucleic Acid Immunostimulating activity (2) Study with patients: • 66 subjects with leucopenia (leucocytes < 3000) • a treatment with HP DNA (800-1200 mg/day for 3 weeks) was effective in 77% of the cases, and the majority just after the first week of treatment

  37. HP DNA • Highly Polymerized Deoxyribonucleic Acid Regenerative action vis-à-vis the cicatriciels process In mice, after the realization of experimental wounds, the administration of HP DNA accelerated the cicatrisation: • by  proliferative activity • by  the number of polypoid epidermal cells In rats, one hour after the administration of 325 mg/kg of aspirin, the taking of HP DNA (10 to 50 mg/kg per os) • prevented the apparition of gastric ulcers from aspirin

  38. HP DNA • Highly Polymerized Deoxyribonucleic Acid Powerful radioprotective activity Survival level after irradiation proportional to polymerization degree of injected heterologous DNA At rats • 24 hours after a lethal irradiation of 1000 rœntgens after injection of 300 g of HP DNA => definitive survival At animal, the administration of HP DNA •  bone marrow aplasia (anemia and leucopenia) experimental radio-induced •  decrease of spermatogenesis secondary to irradiation

  39. HP DNA • Highly Polymerized Deoxyribonucleic Acid Potential Applications => To stimulate immunity => To accelerate the cicatrization => To restore the general state => For physical and psychic asthenia => To improve cognitive performances •  intellectual quotient •  memorization => To improve physical performance •  VO2 max •  recuperation time => To treat basic arthralgies and arthrosis => To reduce the secondary effects of radiotherapy

  40. HP DNA Highly Polymerized Deoxyribonucleic Acid HP DNA, a marine DNA highly polymerized with a strong antioxidant power, with potential applications in health… For asthenia, arthrosis, immunodeficiency, troubles of cicatrisation,…

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