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Chapter 1: Principles of Pharmacology Psychopharmacology Psychoactive drug. Drug Categories. Historical Use of a Drug: Opium. Opium Wars. Historical Use of a Drug: Opium. Opium use in Europe and US. US drug laws. Pure Food and Drug Act – 1906 Harrison Act – 1914

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Chapter 1: Principles of Pharmacology Psychopharmacology Psychoactive drug


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    1. Chapter 1: Principles of Pharmacology Psychopharmacology Psychoactive drug

    2. Drug Categories

    3. Historical Use of a Drug: Opium • Opium Wars

    4. Historical Use of a Drug: Opium • Opium use in Europe and US

    5. US drug laws • Pure Food and Drug Act – 1906 • Harrison Act – 1914 • Prohibition (18th amendment) – 1920 • Controlled Substances Act – 1970

    6. The Life of a Drug in the Body • Route of administration (getting it in) • Absorption/ Distribution (getting to the brain) • Binding (how it works) • Metabolism/Deactivation (stopping it) • Excretion (getting rid of it)

    7. Routes of Administration – Getting the drugs in first-pass effect:

    8. Administration of nicotine by smoking or chewing Method of Administration Affects Blood Concentration Routes of Administration – Getting the drugs in

    9. Absorption and Distribution- getting drug to the brain lipid/water-solubility:

    10. Absorption and Distribution- getting drug to the brain lipid/water-solubility HO HO Morphine Heroin http://www.ch.ic.ac.uk/rzepa/mim/drugs/gifs/heroin.gif

    11. Absorption and Distribution- getting drug to the brain ionization:

    12. Absorption and Distribution- getting drug to the brain blood-brain barrier:

    13. Binding- how drug works • Drug depots:

    14. Binding- how drug works Receptors:

    15. Metabolism- stopping drug effect Excretion- getting drug out of body Half-life:

    16. Excretion- getting drug out of body Metabolism- stopping drug effect

    17. The Life of a Drug in the Body • Route of administration (getting it in) • Absorption/ Distribution (getting to the brain) • Binding (how it works) • Metabolism/Deactivation (stopping it) • Excretion (getting rid of it)

    18. Dose–response curve Other Important Concepts

    19. Dose–response curves for four analgesic agents Other Important Concepts Potency:

    20. Comparison effects of a drug Other Important Concepts

    21. Other Important Concepts Effects of Repeated Drug Use • Tolerance: • Is reversible • Not all drug effects show equal tolerance • Types of tolerance • Disposition • Pharmocodynamic • Behavioral

    22. Effects of Repeated Drug Use Other Important Concepts • Sensitization

    23. Other Important Concepts • Therapeutic effects • Side effects

    24. Drug Development and Testing Other Important Concepts