The main properties of DNA. The genetic material must be able to: Store information Replicate (when cells divide) Express information (as proteins) Mutate at a low frequency (less than 1 in a million) DNA is a molecule that is very well suited to doing all 4 of these. Mutation.
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DNA polymerase makes about 1 mistake per 105 bp.
DNA polymerase has a “proof-reading” activity to correct its
own mistakes (99%).
After DNA replication there is a “mismatch repair” system to
correct remaining mistakes (99.9%).
This leaves an overall error rate of about 1 base in 1010.
Petri dishes containing chemical to test,
liver extract, no histidine
The more mutagenic the chemical,
the more His+ colonies are produced
Number of colonies