Heart transplantation
Download
1 / 89

HEART TRANSPLANTATION - PowerPoint PPT Presentation


  • 81 Views
  • Uploaded on

HEART TRANSPLANTATION. Overall. NUMBER OF HEART TRANSPLANTS REPORTED BY YEAR. AVERAGE CENTER VOLUME Heart Transplants: January 1, 1997 - June 30, 2003. DISTRIBUTION OF TRANSPLANTS BY CENTER VOLUME Heart Transplants: January 1, 1997 - June 30, 2003.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'HEART TRANSPLANTATION' - talbot


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript


Average center volume heart transplants january 1 1997 june 30 2003

AVERAGE CENTER VOLUMEHeart Transplants: January 1, 1997 - June 30,2003


Distribution of transplants by center volume heart transplants january 1 1997 june 30 2003

DISTRIBUTION OF TRANSPLANTS BY CENTER VOLUMEHeart Transplants: January 1, 1997 - June 30,2003


Heart transplants donor age by year of transplant

HEART TRANSPLANTS: Donor Age by Year of Transplant


Age distribution of heart recipients 1 1982 6 2003

AGE DISTRIBUTIONOF HEART RECIPIENTS(1/1982-6/2003)

% of Transplants



Heart transplantation kaplan meier survival 1 1982 6 2002
HEART TRANSPLANTATION Kaplan-Meier Survival(1/1982-6/2002)


Heart transplantation1

HEART TRANSPLANTATION

Adult Recipients



Adult heart transplantation kaplan meier survival by era transplants 1 1982 6 2002
ADULT HEART TRANSPLANTATIONKaplan-Meier Survival by Era(Transplants: 1/1982-6/2002)

Survival (%)


Adult heart transplantation kaplan meier survival by age group transplants 1 1982 6 2002
ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Age Group(Transplants: 1/1982-6/2002)


Adult heart transplantation kaplan meier survival by age group transplants 1 1996 6 2002
ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Age Group(Transplants: 1/1996-6/2002)


Adult heart transplantation kaplan meier survival by gender transplants 1 1982 6 2002
ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Gender(Transplants: 1/1982-6/2002)


Adult heart transplantation kaplan meier survival by diagnosis transplants 1 1982 6 2002
ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Diagnosis(Transplants: 1/1982-6/2002)


Adult heart transplantation kaplan meier survival by diagnosis transplants 1 1996 6 2002
ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by Diagnosis (Transplants: 1/1996-6/2002)


Adult heart transplantation kaplan meier survival by pvr transplants 1 1996 6 2002
ADULT HEART TRANSPLANTATION Kaplan-Meier Survival by PVR (Transplants: 1/1996-6/2002)



Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality


Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality1
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality


Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality2
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality


Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality3
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality


Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality4
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality


Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality recipient age
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityRecipient Age


Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality donor age
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityDonor Age


Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality recipient height
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityRecipient Height


Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality center volume
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityCenter volume


Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality ischemia time
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityIschemia time


Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality recipient bilirubin
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityRecipient Bilirubin


Adult heart transplants 1 1995 6 2002 risk factors for 1 year mortality recipient creatinine
ADULT HEART TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityRecipient creatinine


Adult heart transplants 1 1995 6 2002 factors not significant for 1 year mortality
ADULT HEART TRANSPLANTS(1/1995-6/2002)Factors Not Significant for 1 Year Mortality

Recipient Factors:

VAD, ABO identical/compatible, symptomatic cerebrovascular disease/cerebrovascular event, pneumothorax, pregnancy, pulmonary embolism, PA systolic, cardiac output, weight


Adult heart transplants 1 1995 6 2002 factors not significant for 1 year mortality1
ADULT HEART TRANSPLANTS(1/1995-6/2002)Factors Not Significant for 1 Year Mortality

Donor Factors:

Clinical infection, history of cancer, history of hypertension, history of diabetes, height, weight, cause of death

Transplant Factors:

Donor/recipient BMI ratio, donor/recipient weight ratio


Adult heart transplants 1995 6 1998 risk factors for 5 year mortality
ADULT HEART TRANSPLANTS (1995-6/1998)Risk Factors for 5 Year Mortality

(N=11,963)


Adult heart transplants 1995 6 1998 risk factors for 5 year mortality1
ADULT HEART TRANSPLANTS (1995-6/1998)Risk Factors for 5 Year Mortality

(N=11,963)


Adult heart transplants 1995 6 1998 risk factors for 5 year mortality2
ADULT HEART TRANSPLANTS (1995-6/1998)Risk Factors for 5 Year Mortality

(N=11,963)


Adult heart transplants 1 1995 6 1998 risk factors for 5 year mortality

Wald

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

Wald

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year Mortality


Adult heart transplants 1 1995 6 1998 risk factors for 5 year mortality recipient age
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityRecipient Age


Adult heart transplants 1 1995 6 1998 risk factors for 5 year mortality donor age
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityDonor Age


Adult heart transplants 1 1995 6 1998 risk factors for 5 year mortality donor bmi
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityDonor BMI


Adult heart transplants 1 1995 6 1998 risk factors for 5 year mortality recipient height
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityRecipient Height


Adult heart transplants 1 1995 6 1998 risk factors for 5 year mortality center volume
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityCenter volume


Adult heart transplants 1 1995 6 1998 risk factors for 5 year mortality ischemia time
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityIschemia time


Adult heart transplants 1 1995 6 1998 risk factors for 5 year mortality recipient creatinine
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityRecipient creatinine


Adult heart transplants 1 1995 6 1998 factors not significant for 5 year mortality
ADULT HEART TRANSPLANTS(1/1995-6/1998)Factors Not Significant for 5 Year Mortality

Recipient Factors:

VAD, in hospital, symptomatic cerebrovascular disease/cerebrovascular event, pneumothorax, pregnancy, pulmonary embolism, PA systolic, PA diastolic, PVR, history of malignancy, weight, gender, history of malignancy, bilirubin, PCW


Adult heart transplants 1 1995 6 1998 factors not significant for 5 year mortality1
ADULT HEART TRANSPLANTS(1/1995-6/1998)Factors Not Significant for 5 Year Mortality

Donor Factors:

Gender, cause of death, clinical infection, history of cancer, history of hypertension, history of diabetes

Transplant Factors:

Donor/recipient BMI ratio, donor/recipient height ratio, CMV mismatch, ABO identical/compatible


Heart transplantation
ADULT HEART TRANSPLANTS (1995-6/1998)Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year

(N=9,182)


Heart transplantation
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityConditional on Survival to 1 Year


Heart transplantation
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearRecipient Age


Heart transplantation
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearDonor Age


Heart transplantation
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearDonor BMI


Heart transplantation
ADULT HEART TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearRecipient creatinine


Heart transplantation
ADULT HEART TRANSPLANTS(1/1995-6/1998)Factors Not Significant for 5 Year Mortality Conditional on Survival to 1 Year

Recipient Factors:

VAD, ventilator, in hospital, IV inotropes, balloon, ABO identical/compatible, symptomatic cerebrovascular disease/cerebrovascular event, pneumothorax, pregnancy, pulmonary embolism, PA systolic, PA diastolic, PCW, PVR, history of malignancy, height, weight, gender, diabetes, PRA, bilirubin


Heart transplantation
ADULT HEART TRANSPLANTS(1/1995-6/1998)Factors Not Significant for 5 Year Mortality Conditional on Survival to 1 Year

Donor Factors:

Gender, cause of death, clinical infection, history of cancer, history of hypertension, history of diabetes

Transplant Factors:

Donor/recipient BMI ratio, donor/recipient height ratio, CMV mismatch, HLA mismatch, center volume, ischemia time

Post-transplant Factors:

Dialysis, prolonged graft dysfunction, permanent pacemaker


Heart transplantation
ADULT HEART TRANSPLANTS (1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years

(N=5,952)


Heart transplantation
ADULT HEART TRANSPLANTS (1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years


Heart transplantation
ADULT HEART TRANSPLANTS(1/1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 YearsRecipient Age


Heart transplantation
ADULT HEART TRANSPLANTS(1/1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Donor Age


Heart transplantation
ADULT HEART TRANSPLANTS(1/1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Donor BMI


Heart transplantation
ADULT HEART TRANSPLANTS(1/1990-6/1992)Risk Factors for 10 Year Mortality Conditional on Survival to 3 Years Center volume


Adult heart recipients functional status follow ups january 1996 june 2003
ADULT HEART RECIPIENTS Functional Status(Follow-ups: January 1996 - June 2003)


Adult heart recipients employment status follow ups january 1996 june 2003
ADULT HEART RECIPIENTSEmployment Status(Follow-ups: January 1996-June 2003)


Adult heart recipients rehospitalization post transplant follow ups january 1996 june 2003
ADULT HEART RECIPIENTSRehospitalization Post-transplant(Follow-ups: January 1996 - June 2003)


Adult heart recipients induction immunosuppression follow ups january 2001 june 2003

ADULT HEART RECIPIENTSInduction Immunosuppression (Follow-ups: January 2001 – June 2003)


Adult heart recipients induction immunosuppression follow ups january 2001 june 20031

ADULT HEART RECIPIENTSInduction Immunosuppression (Follow-ups: January 2001 - June 2003)


Heart transplantation

ADULT HEART RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between January 2001 through June 2003

NOTE: Different patients are analyzed in Year 1 and Year 5


Heart transplantation

ADULT HEART RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-upFor follow-ups between January 2001 through June 2003

NOTE: Different patients are analyzed in Year 1 and Year 5


Heart transplantation

PERCENTAGE OF ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEARStratified by Type of Induction (Transplants: January 1, 2000 - June 30, 2002)


Heart transplantation

NUMBER OF REJECTION EPISODES FOR ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEARStratified by Type of Induction (Transplants: January 1, 2000 - June 30, 2002)


Heart transplantation

PERCENTAGE OF ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEARStratified by Maintenance Immunosuppression (Transplants: January 1, 2000 - June 30, 2002)


Heart transplantation

NUMBER OF REJECTION EPISODES FOR ADULT HEART TRANSPLANT RECIPIENTS TREATED FOR REJECTION IN 1ST YEARStratified by Maintenance Immunosuppression (Transplants: January 1, 2000 - June 30, 2002)


Heart transplantation

POST-HEART TRANSPLANT MORBIDITY FOR ADULTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEARCumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April 1994 - June 2003)


Heart transplantation

POST-HEART TRANSPLANT MORBIDITY FOR ADULTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEARCumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April 1994 - June 2003)


Heart transplantation

POST-HEART TRANSPLANT MORBIDITY FOR ADULTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEARCumulative Prevalence in Survivors within 7 Years Post-Transplant (Follow-ups: April 1994 - June 2003)


Heart transplantation
FREEDOM FROM CAV AND RECIPIENTS TREATED FOR REJECTION IN 1ST YEARFREEDOM FROM SEVERE RENAL DYSFUNCTION*For Adult Heart Recipients (Follow-ups: January 1996-June 2003)


Heart transplantation
FREEDOM FROM CAV RECIPIENTS TREATED FOR REJECTION IN 1ST YEARStratified by DiagnosisFor Adult Heart Recipients (Follow-ups: January 1996-June 2003)


Heart transplantation
MALIGNANCY POST-HEART TRANSPLANTATION FOR ADULTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEARCumulative Prevalence in Survivors(Follow-ups: April 1994-June 2003)

”Other” includes: prostate (11, 33, 25), adenocarcinoma (7, 4, 2), lung (5, 3, 2), bladder (4, 5, 5), sarcoma (3, 3, 1), breast (2, 8, 6), cervical (2, 4, 1), colon (2, 2, 3), and renal (2, 7, 3). Numbers in parentheses are those reported within 1 year, 5 years and 7 years, respectively.


Freedom from malignancy for adult heart recipients follow ups april 1994 june 2003
FREEDOM FROM MALIGNANCY RECIPIENTS TREATED FOR REJECTION IN 1ST YEARFor Adult Heart Recipients (Follow-ups: April 1994 - June 2003)


Adult heart transplants 1996 6 2000 risk factors for developing cav within 3 years
ADULT HEART TRANSPLANTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR(1996-6/2000)Risk Factors for Developing CAV within 3 Years

(N=5,787)


Adult heart transplants 1996 6 2000 risk factors for developing cav within 3 years1

Wald RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

Wald

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

ADULT HEART TRANSPLANTS (1996-6/2000)Risk Factors for Developing CAV within 3 Years


Adult heart transplants 1996 6 2000 risk factors for developing cav within 3 years recipient age
ADULT HEART TRANSPLANTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR(1996-6/2000)Risk Factors for Developing CAV within 3 Years Recipient Age


Adult heart transplants 1996 6 2000 risk factors for developing cav within 3 years donor age
ADULT HEART TRANSPLANTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR(1996-6/2000)Risk Factors for Developing CAV within 3 Years Donor Age


Adult heart transplants 1996 6 2000 risk factors for developing cav within 3 years recipient bmi
ADULT HEART TRANSPLANTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR(1996-6/2000)Risk Factors for Developing CAV within 3 Years Recipient BMI


Adult heart transplants 1996 6 2000 risk factors for developing cav within 3 years center volume
ADULT HEART TRANSPLANTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR(1996-6/2000)Risk Factors for Developing CAV within 3 Years Center Volume


Heart transplantation
ADULT HEART TRANSPLANTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR(1996-6/2000)Risk Factors for Developing CAV within 3 Years Recipient Diastolic PA Pressure


Heart transplantation
ADULT HEART TRANSPLANTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR(1995-6/1996)Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year

(N=1,414)


Heart transplantation

Wald RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

Wald

Label Chi-Square DF Pr > ChiSq

ischtime 11.5639 2 0.0031

bilirubin 4.9749 2 0.0831

volume 7.7569 2 0.0207

recipage 18.1816 2 0.0001

donage 100.0851 2 <.0001

creatinine 37.8649 2 <.0001

rec_hgt 30.9831 2 <.0001

bmi_don 5.9576 2 0.0509

pcw 13.0777 2 0.0014

ADULT HEART TRANSPLANTS (1995-6/1996)Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 Year


Heart transplantation
ADULT HEART TRANSPLANTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR(1995-6/1996)Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 YearRecipient Age


Heart transplantation
ADULT HEART TRANSPLANTS RECIPIENTS TREATED FOR REJECTION IN 1ST YEAR(1995-6/1997)Risk Factors for Developing CAV within 7 Years Conditional on no CAV within 1 YearDonor Age


Adult heart transplant recipients cause of death deaths january 1992 june 2003
ADULT HEART TRANSPLANT RECIPIENTS: RECIPIENTS TREATED FOR REJECTION IN 1ST YEARCause of Death(Deaths: January 1992 - June 2003)