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Maximizing MDS Registry Value with Biobanking Matching

Enhancing the MDS registry by aligning with biobanking cells for comprehensive analysis. Various cell types, including bone marrow mononuclear cells, DNA, RNA, peripheral blood mononuclear cells, granulocytes, buccal swabs, serum, and viable cells are utilized. Method involves isolation of cells locally using Ficoll/red cell lysis, DNA and RNA extraction, and central lab processing. Ownership, research fit, informed consent, ICT integration, and financing are key issues addressed with participant questionnaires.

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Maximizing MDS Registry Value with Biobanking Matching

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  1. Enhancing the value of the MDS registrybymatchingbiobanking Cells: Bonemarrowmononuclearcells: DNA + RNA Peripheralbloodmononuclearcells/granulocytes: DNA + RNA Buccal swap: DNA Serum Viablecells: none /only in dedicated centers (?) Method: Isolation of mononuclearcells (Ficoll/ red celllysis) locally Take up cells in DNA lysis buffer and RNAbee Freeze sample Send to central lab for processing Issues: Ownership Scientific board decideswhether research questions fit the goals of the registry Informed consent ICT database coupled to registry Financing => Questionnaire to participants to evaluatepossibilities & wishes

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