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4- 溴 -2- 氟联苯及其 衍生物的合成

4- 溴 -2- 氟联苯及其 衍生物的合成. 梁爽 2011.12.2. 课题背景 实验进展 实验设想. 课题背景. 4- 溴 -2- 氟联苯（ 4-bromo-2-fluoro-biphenyl ）简称 BFBP ，是最近十几年发展的新型医药中间体，是合成具有特殊功能的含氟化合物的重要原料 。. 实验背景. 国外报道， BFBP 的合成路线为由邻硝基苯胺经溴化、芳烃偶合反应、硝基还原、重氮化、放氮反应合成。反应如下：. 课题背景.

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4- 溴 -2- 氟联苯及其 衍生物的合成

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  1. 4-溴-2-氟联苯及其衍生物的合成 梁爽 2011.12.2

  2. 课题背景 • 实验进展 • 实验设想

  3. 课题背景 4-溴-2-氟联苯（4-bromo-2-fluoro-biphenyl）简称BFBP，是最近十几年发展的新型医药中间体，是合成具有特殊功能的含氟化合物的重要原料。

  4. 实验背景 国外报道，BFBP的合成路线为由邻硝基苯胺经溴化、芳烃偶合反应、硝基还原、重氮化、放氮反应合成。反应如下：

  5. 课题背景

  6. 课题背景 国内BFBP主要是用邻氟苯胺经溴化、重化、催化联苯 反应得到，反应如下

  7. 实验进展

  8. 实验进展

  9. 实验进展

  10. 实验进展

  11. 实验设想

  12. Thank You

  13. 反应机理

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