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Public Cord Blood Banking in the United Kingdom. Derwood Pamphilon Consultant Haematologist Medical Director, NHS Cord Blood Bank NHS Blood and Transplant. The NHS Cord Blood Bank. Started clinical banking in February 1996

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public cord blood banking in the united kingdom

Public Cord Blood Banking in the United Kingdom

Derwood Pamphilon

Consultant Haematologist

Medical Director, NHS Cord Blood Bank

NHS Blood and Transplant

the nhs cord blood bank
The NHS Cord Blood Bank

Started clinical banking in February 1996

Accredited by NetCord-FACT* and licensed by the Human Tissue Authority

Present aim

To bank 20,000 altruistic (unrelated) donations

To bank units from ethnic minority groups

Available for search in the British Bone Marrow Donor Registry (BBMR) and NetCord

First unrelated transplant Feb 1998 in a 5 year old child with advanced acute leukaemia who remains well

*Foundation for Accreditation of Cell Therapy

advantages of cord blood banking
Advantages of Cord Blood Banking
  • Readily available: 600,000 live births each year in the UK
  • Short interval from search to transplant
  • Donations from ethnic minorities
  • Low risk of transmission of latent viruses
  • No attrition once bank established
  • T cells are naïve – less Graft-versus-Host Disease (GvHD)
principal elements of cord blood banking
Principal Elements of Cord Blood Banking

Promotion

Donor mother recruitment

Donor selection

Maternal blood samples

Cord blood collection

Transport

Lab management

Quality system

Testing

HLA typing

Data management

Registration

Traceability

Request

Process

Search

Cryopreservation

Selection

Storage

Reservation

Release & Issue

Archive samples

Follow up

what have we achieved
What Have We Achieved?

Banking

  • 13,500 units banked
  • 4th largest single public bank in the world
  • 2nd highest % of rare tissue types

Issued

  • 260 units to 22 countries
  • 34% units issued were from donors from ethnic minorities
  • 30% for double cord transplants

Survival

  • 2 year survival - 69% in high risk patients receiving HLA (Human Leucocyte Antigen or ‘Tissue Type’) matched or grafts

Geographical Distribution of NHS Cord Blood Bank Units Issued (n=173)

public donation now and in the future
Public Donation Now and in the Future
  • Our emphasis is on providing stem cells for therapy where clinicians agree that benefit is likely
  • Possible increase in collection sites in areas with high ethnic diversity
  • Potential exists for collaboration with the private sector (Technopolis Report)
  • Public donation remains an altruistic choice
should the nhs take steps to increase public awareness
Should the NHS take steps to increase public awareness?
  • Develop a National Policy on Cord Blood with a high-level advisory committee*
  • Provide all hospitals with a level playing field
  • Ensure that all hospitals make clear and accurate information on cord blood banking available
  • Develop clear guidelines for private banks regarding the information they supply

*Technopolis Report, September 2008

the next 10 years of cord blood
The Next 10 Years of Cord Blood
  • Possible further expansion in the UK to 50,000*
  • Double cord blood transplants
  • Cord Blood + half-matched adult stem cells
  • Cord blood for regenerative medicine and tissue repair

Querol et al, Hematologica, 2009

acknowledgements
Acknowledgements

Colin Brown

Hazel Cockburn

Marcela Contreras

Sue Davey

Jon Ellis

Jesmina James

Delordson Kallon

Cristina Navarrete

Fiona Regan

John Smythe

Suzanne Watt

www.cord.blood.co.uk