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All Pathways. Extracellular. Wnt. TGF- β. Click to continue. Cell-matrix junction. Cell-cell junction. GPCR. Adenylyl Cyclase. Black = ligand. PIP 2. Line = inhibits next step. DAG. RTK. Wnt receptor. TGF- β receptor. PIP 2. PIP 3. PI3- kinase. G- protein. PLC.

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all pathways
All Pathways

Extracellular

Wnt

TGF-β

Click to continue

Cell-matrix

junction

Cell-cell

junction

GPCR

Adenylyl

Cyclase

Black = ligand

PIP2

Line = inhibits next step

DAG

RTK

Wnt

receptor

TGF-β

receptor

PIP2

PIP3

PI3-

kinase

G-

protein

PLC

Return to main page

Smad

Click on any yellow box

Click on any yellow box

Click on any yellow box

PTEN

PKB-AKT

β-

catenin

GTP

APC

PKC

Ras

cAMP

IP3

GTP

Apoptosis

Previous pathway

Kinase

cascade

Red = inhibits cell growth

Ca2+

Go to next pathway

FAK

mTOR

Green = increases cell growth

SRC

PKA

Cam-Kinase

Arrow = leads to next step

Nucleus

(cell growth)

Intracellular

all pathways1
All Pathways

Extracellular

Wnt

TGF-β

Cell-matrix

junction

Cell-cell

junction

GPCR

Adenylyl

Cyclase

PIP2

DAG

RTK

Wnt

receptor

TGF-β

receptor

PIP2

PIP3

PI3-

kinase

G-

protein

PLC

Smad

PTEN

PKB-AKT

β-

catenin

GTP

APC

PKC

Ras

cAMP

IP3

GTP

Apoptosis

Kinase

cascade

Ca2+

FAK

mTOR

SRC

PKA

Cam-Kinase

Nucleus

(cell growth)

Intracellular

slide3
GPCR

Extracellular

GPCR

Adenylyl

Cyclase

DAG

PIP2

G-

protein

PLC

GTP

PKC

cAMP

IP3

Kinase

cascade

Ca2+

PKA

Cam-Kinase

Nucleus

(cell growth)

Intracellular

slide4
RTK

Extracellular

PIP2

DAG

RTK

PIP2

PIP3

PI3-

kinase

PLC

PTEN

PKB-AKT

PKC

Ras

IP3

GTP

Apoptosis

Kinase

cascade

Ca2+

mTOR

Cam-Kinase

Nucleus

(cell growth)

Intracellular

slide5
PTEN

Extracellular

PIP2

PIP3

PI3-

kinase

PTEN

PKB-AKT

Apoptosis

mTOR

Nucleus

(cell growth)

Intracellular

pi3 kinase
PI3-Kinase

Extracellular

PIP2

PIP3

PI3-

kinase

PTEN

PKB-AKT

Apoptosis

mTOR

Nucleus

(cell growth)

Intracellular

cell matrix junction
Cell-Matrix Junction

Extracellular

Cell-matrix

junction

Ras

GTP

Kinase

cascade

FAK

SRC

Nucleus

(cell growth)

Intracellular

cell cell junction
Cell-Cell Junction

Extracellular

Cell-cell

junction

β-

catenin

APC

Nucleus

(cell growth)

Intracellular

slide9
Wnt

Extracellular

Wnt

Wnt

receptor

β-

catenin

APC

Nucleus

(cell growth)

Intracellular

slide10
TGF-β

Extracellular

TGF-β

TGF-β

receptor

Smad

Nucleus

(cell growth)

Intracellular

oncogene tumor suppressor molecular pathways

Oncogene/Tumor Suppressor Molecular Pathways

Dan Cushman

Robert Warren, PhD

2009