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AP Biology (An Introduction). Mr. Boswell Room 208. CUSTOMARY INTRODUCTION TO COLLEGE BIOLOGY. INTRODUCTION TO 21 ST CENTURY SCIENCE. Molecular Biology Revolution. Have you heard about it? Increase life span Increase quality of life Compare to The Internet. Alba – GFP bunny

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ap biology an introduction

AP Biology(An Introduction)

Mr. Boswell

Room 208

slide2

CUSTOMARY INTRODUCTION

TO

COLLEGE BIOLOGY

slide3

INTRODUCTION TO

21ST CENTURY SCIENCE

molecular biology revolution
Molecular Biology Revolution
  • Have you heard about it?
  • Increase life span
  • Increase quality of life
  • Compare to The Internet
slide5

Alba – GFP bunny

  • Expired in 2002
  • “Transgenic art”
  • AP Lab #6
human genome project
Human Genome Project
  • Completed in 2003
    • Joint Genome Institute (Walnut Creek, CA)
    • Sequenced entire human genome (DNA)
  • Cost $2.7 billion
  • 2004, Celera (J. Craig Venter) = $300,000,000 (11%)
  • 2010, Illumina (San Diego, CA) = $14,500 (0.0005%)
  • 2013, $1,000 or less (estimate)
slide8

“We are now part of an early radical biological revolution that will dwarf the industrial revolution.”

-- Julian Savulescu (Oxford University)

futurama
Futurama
  • Last year – Juan Enriquez video
    • Now it is outdated
21 st century therapies
21st Century Therapies
  • Gleevec – Chronic Myelogenous Leukemia
    • 1 pill a day
    • Sprycel & Tasigna
  • BrCa-1 and BrCa-2 gene tests for breast and ovarian cancer
  • In 2010, Oncept DNA Vaccine
    • Canine Oral Melanoma
    • Transdermal application
  • June 2010, “siRNA ‘Cure’ for Ebola?” (Geisbert et al.)
venter institute
Venter Institute

August 2009 – 1st Genetically Engineered Organism

Altered Yeast genome  bacterium

May 2010 – Four bottles (ACTG) + signals = Fully functional Mycoplasma mycoides genome

Not just engineering bacteria, but creating them

slide12

http://ung.igem.org/Team_List?year=2011

http://2011.igem.org/Main_Page

tracheal replacement
Tracheal Replacement
  • Lab made organ implanted for first time
    • Trachial Cancer patient
    • Not tissue derived from patient, entirely foreign materials
    • Made in London, UK  Stockholm, Sweden
what does this mean
What does this mean?
  • 2008 Plastic Surgeons performed 10.2 Million procedures
    • Corrections, deletions, augmentations, & enhancements
  • What will happen when you can design organs, limbs, ...?
hugh herr
Hugh Herr

"When you go into my closet, there are many, many pairs of legs. I have a running pair, I have a bionic walking pair, limbs that are waterproof," he says. "I have various legs to climb mountains and to sense steep ice walls, other feet that wedge into small rock fissures [and] others that stand on small rock edges the width of a coin.”

“My biological body will degrade in time…, but the artificial part of my body will improve over time since I can upgrade.”

http://www.npr.org/2011/08/10/137552538/the-double-amputee-who-designs-better-limbs

engineering humans
Engineering Humans
  • Engineering Children
    • Already determine gender & eliminate some diseases
    • What amount of intelligence will your child have?
    • Will you give them the 577R genotype in the ACTN3 gene?
      • 84% of Africans have it, 49% of Eurasians have it
      • What about Olympic athletes?
  • Engineering Adults
    • Hear ultrasound frequencies
    • Telescopic vision
exit interview comments
Exit Interview Comments
  • “…take the class only if you enjoy biology or the sciences.”
  • “If he/she doesn’t wish to go into the field of science, I’d highly dissuade them from taking the course.”
  • “If a student is only taking a course to have it on her transcript then she will have a horrible time.”
  • “…you must learn a ton of information in a short period of time.”
page 2
Page 2
  • “AP Biology is nothing like honors Biology.”
  • “…the teacher should have removed students from the class who were not up to the standards of the course.”
  • “Some people played on the computer or did not pay attention in class. Why are they still here?”
2010 ap biology results
2010 AP Biology Results
  •  Pass Rate = 90%
  • “5”s = 52%
  • “5” + “4” = 77%
  • Students = 64
why this class is difficult
Why this class is difficult…

1. Biology knowledge base is deficient

 How many years ago did you take Honors Biology?

2. Honors Biology ≠ AP Biology

3. 55 Chapters (1,230 pages)

4. 3 credits vs. 8 credits

why this class not difficult
Why this class not difficult…

1. Clear expectations

  • Vocabulary & Objectives

2. Information is readily available

3. Course Materials sourced from 3 Biology textbooks

4. Course materials are easily accessible

5. Few complicated concepts

what is a college level course
What is a College Level Course?
  • Student-Driven Learning
  • Role of teacher is to highlight some important points
  • Will NOT cover every concept in class
  • “students are expected to work independently outside the class”
class discussions
Class Discussions
  • You WILL be called on to attempt an answer
  • I want to hear what you have to say
  • Make all questions and comments relevant to the content discussion
    • If your question is off topic, write it down and ask it later
background
Background
  • Undergrad: Philosophy & Biochemistry
  • Masters: Medical Economics & Epidemiology
  • HHMI (Howard Hughes Medical Institute) Cohort
    • Inaugural Fellow (2008) @ University of Florida
    • Translational Medicine Institute (2011) @ UF
  • AP Summer Institute (2007, 2008, & 2009)
    • Nova SE, BCPS, and Stanford University
  • AP Annual Conference (2008) in Seattle, WA
assignments
Assignments
  • Diagnostic Test due by 2:00 am Tonight !!!
    • Biology: Diagnostic Test – (45 minutes)
    • http://www.quia.com/quiz/3231852.html
  • Student Information Survey
    • http://www.quia.com/sv/540447.html
      • Any questions on the Student Survey, email me @ bb@ap-bio.com
      • Due by 2:00 am Tonight !!
assignment page 2
Assignment (Page 2)
  • http://www.ap-bio.com
  • Student Handbook 2011: Printout, Read, & then Sign
    • Due Wednesday 8/24/11
      • Statement of Understanding (Page 4)
      • Lab Safety Contract (Page 4)
      • Academic Integrity (Honor Code) (Page 5)
      • AP Exam Exception (Page 6)
  • Homework / Summer Project
    • Due in class Wednesday 8/24/11
assignment page 3
Assignment (Page 3)
  • If you have not gotten emails from Mr. Boswell, make sure you add name to email list
  • Chapters 2 & 3 tomorrow