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Haematological and Immunological Profiles of Wild-Type and IL-4Ra-/- Mice

This study investigates the haematological and immunological characteristics of wild-type and IL-4Ra knockout mice. Blood cell counts were analyzed using a veterinary blood counter, revealing no significant differences between the groups. Splenocytes were examined to assess CD8a, CD4, CD11b/Gr1 (myeloid-derived suppressor cells), and CD4.CD25.FoxP3 (regulatory T cells) expression. The analysis shows that the number of MDSCs in IL-4Ra-/- tumor-bearing mice is significantly lower compared to wild-type tumor-bearing mice. No other significant differences were found.

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Haematological and Immunological Profiles of Wild-Type and IL-4Ra-/- Mice

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  1. A B Supplementary Figure 3. Haematological and immunological characteristics of wild-type and IL-4Ra-/-mice. A) Blood cell counts were carried out on each mouse using a veterinary blood counter. No significant difference was observed between the groups. Open symbols indicate data from a tumour-bearing mouse. Filled symbols denote values from non-tumour-bearing animals. B) Splenocytes were examined for CD8a, CD4, CD11b/Gr1 (identifying myeloid-derived suppressor cells [MDSC] )and CD4 CD25 FoxP3 (identifying Treg cells) expression. Female mice only are shown. Open symbols indicate data from a tumour-bearing mouse. Filled symbols denote values from non-tumour-bearing animals. No significant difference was observed between the groups (Kruskal-Wallis test followed by Dunn’s multiple comparison test), except that the number of MDSCs in IL-4Ra-/- tumour-bearing mice was significantly lower than WT tumour-bearing animals (P=0.016; Mann-Whitney test).

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