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Scanpath variation in individuals with 22q11.2 deletion syndrome during the Benton Visual Retention Test . Marie-Christine Ottet, Bronwyn Glaser, Manolo Fuentes, Catherine Pasca, M él anie Chabloz, Martin Debban é , Stephan Eliez. How do we look at things ?. Why is this pertinent to VCFS ?.

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slide1

Scanpath variation in individuals with 22q11.2 deletion syndrome during the Benton Visual Retention Test

Marie-Christine Ottet, Bronwyn Glaser, Manolo Fuentes, Catherine Pasca, Mélanie Chabloz, Martin Debbané, Stephan Eliez

why is this pertinent to vcfs
Why is this pertinent to VCFS ?

Previous findings:

  • Deficits in attentional skills (Simon et al., 2002; Bish et al., 2005)
    • Efficient scanpath needs attention
  • Deficits of visuo-spatial memory (Bearden et al., 2001)
    • Alteration of parietal lobe (Simon et al., 2005)
    • Memory relies on visual exploration
  • Parents report an incomplete visual exploration
population
Population
  • 78 participants
    • 41 VCFS and 38 Controls
    • Range of age : 8 to 26 years
  • 2 types of evaluation :
    • Cognitive: with an Eyetracker
    • Cerebral: with MRI scans
benton visual retention test bvrt computer version
Benton Visual Retention (Test BVRT)Computer version
  • BVRT multiple choice
    • 10 cards with geometric figures
how to measure and analyze the scanpath
How to measure and analyze the scanpath
  • Eyetracker Tobii 1750
  • Measurements of the eyetracker
    • Total time and spread of exploration
    • Number, duration and coordinates of fixation points
  • Analyze regions of interest (AOI)
    • 3 groups of figures
      • Main simple figure
      • Main complex figure
      • Peripheral figure
global results
Global Results
  • Less fixations
  • More spread
  • Same areas oberved

Controls

VCFS

Controls

VCFS

results of aoi
Results of AOI

In red : lower number of fixations made by VCFS

10.78>8.67

8.45>6.83

10.24>8.63

2.68>1.44

Image 3

Image 1

Image 2

5.50>4.59

2.11>1.15

2.29>1.54

Image 4

Image 5

Image 6

3.58>2.56

2.34>1,51

1.45>0.98

1.39>0.83

1.76>1.12

5.87>4.22

Image 7

  • Image 8

Image 9

4.82>3.71

1.42>0.59

Image 10

results analysis of aoi
Results: Analysis of AOI
  • Less fixations on :
      • 7 of 8 peripheral figures
      • 5 of 7 main simple figures
    • 2 influences:
  • Spatial deficits

Lateral « negletion » of the image

      • Less fixations on peripheral figures
      • Alterations of the parietal lobe
  • Attentional deficits

Deficit in attentional disengagement

      • Less fixations on main figures simples
      • Alterations of the frontal lobe

Image 1

Image 2

Image 3

Image 5

Image 6

Image 4

Image 7

  • Image 8

Image 9

Image 10

anatomical cerebral measurments
Anatomical cerebral measurments
  • Method : FreeSurfer (http://surfer.nmr.mgh.harvard.edu/)

Measure of the volume of gray matter of the cortex

  • parcels of frontal lobe
  • parcels of parietal lobe

Automatic subdivision of the cortex: Desikan, R.S., (2006)

analysis of parcel volumes related to the scanpath
Analysis of parcel volumes related to the scanpath

Left hemisphere

  • Correlations controled for age and gender between :
    • Gray matter volume
    • AOIs
  • Caudal middle frontal
  • Precentral
  • Postcentral
  • Superior frontal
  • Anterior cingulate
  • Parahippocampal

Right hemisphere

  • Caudal middle frontal
in summary
In summary
  • Same areas observed between groups but less precise scanpath in VCFS (number, duration and spread)
  • Deficits attentional and spatial on global scanpath
  • Possible alteration of the motor planification
how do our results guide interventions
How do our results guide interventions ?
  • Importance in treatment of attentional deficit:
    • Cognitive remediation
    • Medical treatments
  • Strategies
    • Always start with the sides of images
    • Salient stimulus on important items (e.g. key word in red for homework)
thank you
Thank you…

… for your attention

acknowledgment
Acknowledgment

Thanks to the associations

Generation22

Connect22

Relais22

Financial Support

SNF

CIBM

Eagle

FHMS

NARSAD

Von Meissner

Thanks to collegues

Stephan Eliez

Martin Debbané

Bronwyn Glaser AnnaLaura Lagioia Marie Schaer

Maude Schneider

Catherine Pasca

Mélanie Chabloz

Bertrand Auckenthaler

Michal Epstein

Catherine Audrin

Manolo Fuentes

Ryan Murray

Thanks to all the families