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Parkinson’s & a plant based diet . Danielle Selden Alicia Armeli. Proof in plants . Higher Quality of life . A concerning underlying problem with our current method of treatment- its not working long term .

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parkinson s a plant based diet

Parkinson’s & a plant based diet

Danielle Selden Alicia Armeli

why we chose this article
Proof in plants

Higher Quality of life

  • A concerning underlying problem with our current method of treatment- its not working long term.
  • Two recent studies have shown that a plant-based dietary pattern may protect against PD.
  • This peer-reviewed article looks at the effectiveness of a plant-food diet in the management of PD.
Why we chose this article....
currently there is no cure
Quick Facts about Parkinson’s Disease (PD):

PD is a chronic progressive movement disorder in which the neurons that produce dopamine are impaired.

PD is characterized by slow and decreased movement, muscular rigidly, resting tremor, postural instability, and decreased dopamine transmission to the basal ganglia. Since Dopamine is not available movements can not be controlled.

Etiology is unclear but is thought to arise from both genetic and environmental factors.

Treatment includes medication, surgery, and other modalities to manage symptoms.

Currently there is no cure....
introduction

Preventing a high protein based diet is critical for treatment.

  • Levodopa, a prodrug of dopamine (derived from the A.A tyrosine), remains the most effective treatment to alleviate motor dysfunction in PD.
  • “The Protein Redistribution Diet” was formulated to avoid the risk of nutritional deficiencies linked to extreme restriction in total protein intake.
  • This intervention consists of a normoproteic diet- a pt’s main protein intake occurs in the evening meal in order to limit the negative interaction of LNAA on L-Dopa’s response at daytime, while the negative effects act up during sleep at night.
Introduction
why a plant food diet

A plant-food vegan diet (PFD) is expected to raise L-Dopa availability and bring some advantage in the management of disease.

  • This pilot study was designed to establish whether a PFD normoproteic protein redistribution diet can be just as effective as a protein-redistributed OD in improving motor performance in L-Dopa treated PD patients in the short term.
Why a plant-food diet?
subjects

All 25 participants in the study were PD patients

  • 12 were in the intervention group (PDi) and 13 in the control group (PDc), respectively.
  • Pt’s have had a good response to levodopa in the past, with a daily dose over 350mg, under 850mg, and over 50 years of age, BMI over 18.5 and under 30.
  • Pt’swere already following advices to limit total animal protein and to concentrate them in an evening meal in the context of an OD.
  • Pt’swere given the choice to consume the PFD or the usual OD for a 4-week period.
Subjects
methods and measures
A quasi-experimental non-equivalent group design (NEGD) was utilized.

The PD intervention (PDi) diet/vegan diet- includes plant-protein rich sources only for dinner (2/3 of total daily intake of PRO)

The control group (PDc)/omnivorous diet- limited total animal food and concentrated them in the evening meal

Neurological assessments were made by an experienced neurologist using the comprehensive PD measurement tool United Parkinson’s Disease rating system

Mann-Whitney

Sun Score

Hoehn and Yahr

Methods and Measures
results

After 4 weeksthe PDi group showed a significant reduction with respect to the PDc group in...

  • Metabolic changes in the PDi group- total cholesterol, HDL cholesterol, apo-A1, and apo-B showed significant differences after 4 weeks.
Results
limitations

Lack of random assignment of subjects to intervention or control groups.

  • Both groups have small sample sizes.
  • Short study time- 4 weeks.
  • Lack of blood measurements of levodopa and dietary LNAA at the enrolment and after 4 weeks.
Limitations
conclusions

This study showed after 4 weeks of a PFD in the PDi had a value 27 points (47.67 vs. 74.46) lower than the PDc group, a result that is clinically relevant.

  • Due to its high fiber content, a PFD can potentially raise levodopa bioavailability by reducing the phenomenon of constipation.
  • Consumption of a PFD is may be more effective than an OD for improving motor performances in PD pts.
  • Additional studies need to be performed, especially longitudinal randomized trails of larger groups
Conclusions
a comprehensive plan for pd patients

Increase Antioxidants/ phytochemicals and mitochondrial stabilizers:

    • CoQ10 and Vitamin E
    • Vitamin D and Omega 3’s
    • Magnesium
    • Alpha lipoic acid
  • Fava Beans- 3oz. Contain levodopa
  • Vegan diet
  • Acupuncture- shows reduced sxs
  • Massage- anecdotal evidence of reduced sxs
A comprehensive plan for PD Patients
references

BaroniL, Bonetto C, Tessan F, Goldin D, Cenci L, Magnanini P, Zuliani. Pilot dietary study with normoproteic protein-redistributed plant-food diet and motor performance in patients with Parkinson’s disease. Nutritional Neuroscience. 2011;14:1:1-9.

Mahan K L, Escott-Stump S, Raymond J L. Krause’s Food and the Nutrition Care. St. Louis, MO: Elsevier Saunders; 2012: 675-708.

Parkinson’s Disease Foundation. Available at: http://www.pdf.org. Accessed May 30, 2012.

The Parkinson’s Foundation. Available at http://www.parkinson.org. Accessed May 31, 2012.

The Natural Standard. Parkinson’s Disease. Available at http://www.naturalstandard.com. Accessed May 30, 2012.

References