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Impact of PEG400 on Benzoic Acid Solubility: Results and Discussion

This study explores the effect of PEG400 on benzoic acid solubility, indicating an exponential relationship with volume fraction. The experiment also delves into the impact of cosolvency on mass transfer and the ease of obtaining perfect sink conditions. Enhanced solubility through cosolvency can aid in future experimental data studies.

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Impact of PEG400 on Benzoic Acid Solubility: Results and Discussion

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  1. Results and DiscussionBy: Victor, Eduard and David

  2. Effect of PEG400 on the Solubility of Benzoic acid Drug solubility is dependent on the volume fraction of the cosolvent The solubility of benzoic acid in aqueous PEG 400 is given by: Cs = 4.4 exp(6.27X) at 37° Cs = 2.6 exp(5.41X) at 20° X is the volume fraction of PEG 400

  3. Effect of Cosolvent on Mass Transfer The solubility of benzoic acid in 40% PEG 400 solution Perfect sink conditions could easily be obtained due to high solubility The concentration solution was observed to increase proportionally with time Increased solubility by cosolvency can ease treatment of experimental data in future studies

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