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Medical Research Council Presentation to the Portfolio Committee on Arts, Culture,

Medical Research Council Presentation to the Portfolio Committee on Arts, Culture, Science and Technology September 3, 2002. VISION Building a healthy nation through research. MISSION

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Medical Research Council Presentation to the Portfolio Committee on Arts, Culture,

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  1. Medical Research Council Presentation to the Portfolio Committee on Arts, Culture, Science and Technology September 3, 2002

  2. VISION Building a healthy nation through research

  3. MISSION To improve the nation’s health status and quality of life through relevant and excellent health research aimed at promoting equity and development

  4. KEY STRATEGIC IMPERATIVES Values & Ethics Health Research Priorities Vision & Mission MRC STRATEGY Risk Assessment KPI’s

  5. Board Executive Management Committee President National Programme-Environment and Development Alcohol and Drug Abuse Research Group Exercise Science and Sports Medicine Research Unit Health and Development Research Group Health Promotion Research and Development Group National Programme-Health Systems and Policy Burden of Disease Research Unit Biostatistics Unit Cochrane Centre Health Policy Research Group Health Systems Research Unit National Telemedicine Lead Programme Executive Directors National Programme-Infection and Immunity Amoebiasis Research Unit Clinical and Biomedical Tuberculosis Research Unit Diarrhoeal Pathogens Research Unit Genital Ulcer Disease Research Unit HIV Prevention and Vaccine Research Unit Immunology of Infectious Disease Research Unit Inflammation and Immunity Research Unit Malaria Research Lead Programme Operational and Policy Tuberculosis Research Group Pneumococcal Disease Research Unit South African Traditional Medicines Research Unit Tuberculosis Research Lead Programme National Programme-Non Communicable Diseases Anxiety and Stress Disorders Research Unit Cancer Epidemiology Research Group Chronic Diseases of Lifestyle Research Unit Crime, Violence and Injury Lead Programme Dental Research Institute Diabetes Research Group Interuniversity Cape Heart Research Group Medical Imaging Research Unit PROMEC Unit National Programme-Molecules to Disease Bioinformatics Capacity Development Research Unit Bone Research Unit Centre for Molecular and Cellular Biology Human Genetics Research Unit Human Genomic Diversity and Disease Research Unit Liver Research Centre Molecular Hepatology Research Unit Molecular Mycobacteriology Research Unit Oesophageal Cancer Research Group SA MRC/British MRC Molecular Reproductive Endocrinology Research Group National Programme-Woman and Child Health Gender and Health Research Group Maternal and Infant Health Care Strategies Research Unit Mineral Metabolism Research Unit Nutritional Intervention Research Unit Perinatal Mortality Research Unit Pregnancy Hypertension Research Unit

  6. CAUSES OF DEATH IN 1996

  7. RESEARCH SPENDING Baseline Contract 13% 14% 1% 8% HIV Aids HIV Aids 5% TB TB 6% Malaria 51% Malaria Womens Health 4% 14% Nutrition Womens Health 62% Other 7% Nutrition Other 15% Total 31% HIV Aids 39% TB Malaria Womens Health Nutrition Other 12% 4% 10% 4% •        The MRC spends nearly 40% of its baseline direct research budget on the 5 key areas listed. •        Nearly 85% of all contract income earned is spent on the 5 key areas listed (50% on HIV/AIDS). •        More than 60% of all direct research income (contract and baseline) will be spent on the key areas.

  8. MRC KPI MODEL Building a healthy nation through research Stakeholder Perspective Financial/Investment Perspective Innovation, Learning and Growth Perspective Internal/Organisational Perspective Transformation Perspective • The Financial and Investment Perspective contains indicators for economic sustainability, value adding to stakeholders, investment in organisational processes and innovation/learning. • The Transformation Perspective recognises development through diversity as a business imperative and enables the alignment of skills, processes and systems. • The Innovation and Learning Perspective is key to the future sustainability of the organisation. It is a long-term investment perspective in human resource development and knowledge management. • The Internal/Organisational Perspective provides an enabling environment for relevant and appropriate productive research. • The Stakeholder Perspective forms the vital link between the research function and the socio economic development impact. Key stakeholders include the legislature, community and industry.

  9. STRATEGIC INVESTMENTS (2002/2003) (Baseline) Research Capacity Development/Transformation Human Resource Capital Development and Retention Increase in respect of RFA grants Expanding the MRC Provincial Outreach Programme New Initiatives Biotechnology Information Racial Disparities in Health Research Group Ethics Research Research Translation and Implementation Traditional Medicines Clinical Trial Platform AIDS Portal Africa Research Exchange and Fellowship Programme KPI Additional funding for priority-driven research initiatives HIV Behavioural Science Research Tuberculosis Malaria Violence and Injury

  10. · To reduce the burden of disease and improve service delivery through relevant research and supporting the development of evidence-based policy within an ENHR framework. National health · To become leaders in health research and technology development and implementation through contributing to NACI’s goals and increasing our global scientific competitiveness. National innovation · To become a health and development centre of excellence for the African continent through sustainable global networks, and collaboration with and harnessing of the resources of the continent. International collaboration · To foster an enabling and learning environment that attracts, develops and retains the appropriate HR competencies aligned with both the MRC’s and national S&T strategies. Intellectual capital · To achieve economical sustainability through increasing our contracts and grants income, commercialisation of intellectual assets and the implementation of innovative business models and processes. Economic sustainability · To create an enabling environment by participating in inter-sectoral programmes and initiatives in socio-economic development. Socio-economic development · To become a values-driven organisation through diversity and empowerment embedded in a business orientation. Transformation · To achieve operational/organisational excellence through the implementation of innovative management systems and structures to improve competitiveness, productivity and quality. Operational excellence STRATEGIC AREAS

  11. National Health System To reduce the burden of disease and improve service delivery through relevant research and supporting the development of evidence-based policy within an ENHR framework • Reports • - The impact of HIV/AIDS on adult mortality in South Africa. • - Home-based care for people with HIV/AIDS in South Africa.What will it cost? • - Rapid Appraisal of Mortality Statistics in Cape Metropole. • - Evaluation of the New Death Notification. • Policy Impacts • - Impact of tobacco on health • - Violence against women • Policy Recommendations • - Targeting HIV-prevention efforts on truck drivers and sexworkers: Implications for a decline • in the spread of HIV in southern Africa (December 2000). • - Solving iodine deficiency in South Africa: So near – and yet so far (August 2000) • - Use of insecticide-treated bednets by communities reducemalaria transmission in comparison to house spraying inKwaZulu-Natal (April 2000).

  12. To become a health and development Centre of Excellence for the African continent through sustainable, global networks and collaboration and harnessing the resources of the continent.Scope of Collaboration International Collaboration Some examples of collaboration and partnering in international research projects ·HIV/AIDSPrevention & Vaccine DevelopmentResearchUnit NIH The MRC has received major research grants to conduct and manage (a) the Southern African – New York HIV Vaccine Trials Unit and (b) the South African MRC HIV Prevention Trials Unit.Total fundingR120 million. ·MalariaResearch Programme Mozal Community Development Trust R4,7 million has been granted to provide and manage malaria control systems to the communities living near the Mozal Aluminium Smelter in Maputo, Mozambique. ·Tuberculosis Drug Research The Rockefeller Foundation Money was granted to the MRC to establish an International Co-ordinating Office and Resource Centre for the coalition of TB Research and Development. Funds (R1,52 million over 3 years) have been granted to support a collaborative partnership to create a South African gender based violence and health initiative. ·Gender and Health Group (Womens Health) The Rockefeller Foundation ·HIV/AIDS Prevention & Vaccine Development Research Unit NIH The Institute of Child Health and Human Development has awarded a grant of R1,6 million for 3 years to conduct a study on the Acceptability of Vaginal Microbicides. SADC has contracted the MRC, through funding from the European Union, for the development and Epidemiological Network on Substance Abuse (SENDU) in all SADC member states. The value of the 5 year contract is R2,8 million. ·Alcohol and Drug Abuse Research Group SADC (European Union Funding) ·Malaria Research Programme WHO The WHO has awarded the MRC funding to the value of R1 million for research projects on insecticide resistance and the extension of the “Mapping Malaria Risk in Africa” project. ·Health Technology Research Group GlaxoSmithKline GlaxoSithKline (UK) has renewed its contract with the MRC to manage the South African component of the international “Action TB” project. The value of the contract for 2001/2002 is R5,9 million

  13. Name Name Name Name Number Number Number Number Bone growth Bone growth Bone growth Bone growth 3 3 3 3 CVD diagnostic CVD diagnostic CVD diagnostic CVD diagnostic 1 1 1 1 Palmtop epidemiology software Palmtop epidemiology software Palmtop epidemiology software Palmtop epidemiology software 1 1 1 1 Antimalarials Antimalarials Antimalarials Antimalarials from plant origin from plant origin from plant origin from plant origin 2 2 2 2 TB TB TB TB 1 1 1 1 Anti Anti Anti Anti - - - - Cancer Component Cancer Component Cancer Component Cancer Component 2 2 2 2 TOTAL TOTAL TOTAL TOTAL 10 10 10 10 ·  Innovation and intellectual property A number of new patents in the area of Biotechnology, Information Technology and Materials Technology have been filed and are in various stages of commercialisation.

  14. Health & Socio-Economic Development To create an enabling environment by participating in inter-sectoral programmes and initiatives in socio-economic development. ·  Socio-Economic Impact

  15. ·Job creation and growth Job creation for researchers, and thus increasing the science base of the country, is one of the most important outcomes of the foreign exchange generated by international grants. CONTRACT APPOINTMENTS 1995 - 2000 Staff Total No. of Cont. App. 500 s e 400 e y o 300 l p m e 200 f o . 100 o N 0 1995 1996 1997 1998 1999 2000 451 431 442 477 489 532 3 6 6 22 75 111

  16. Employment Equity RACE GENDER Female 72.0% Black 78.0% White 22.0% Male 28.0%

  17. MRC EMPLOYMENT EQUITY 2002

  18. Capacity Development- Of the 55 masters and doctoral scholarships awarded, 70% wereawarded to black applicants and 25% of the bursars are located at historically black universities (HBUs).- In the past year an additional R1 million was invested on new short-term research grants and 40% of the additional funds were awarded to successful applicants from the HBUs.- In the past year the MRC increased its investment in bursaries and scholarships by 12%. - The number of post-doctoral scholarships awarded was increased from 5 to 9.- A new category of research training scholarships for the allied health professionals was introduced and 8 scholarships were awarded in the first round.-Work-study positions for undergraduate students were created in the MRC units and groups. Five such bursaries were awarded this year.

  19. National Contribution to the Development of Health Researchers MRC Bursaries and Research Trainees (76) Other Funding Sources (123) MRC Employees (56) NRF Bursars (30) Provincial Employees (54) University Support (56)

  20. MRC publication output in peer-reviewed journals: 1996-2001(excluding publications from RFAs) e u l a v d n a r 1997 data exclude National Tuberculosis Research Programme

  21. ·NEPAD (Major intercontinental networks) - SAZA Project Evaluating health financing reform in South Africa and Zambia - Mapping Malaria Risk in Africa Collaboration with 8 data collection centres and Lubombo SDI (South Africa, Swaziland and Mozambique). - Indigenous Knowledge University, Science, Humanities, Engineering Partners in Africa (USHEPIA)- IKS and Malaria - Telemedicine WHO Centre for Telemedicine in the developing world - SENDU South African Development Community Epidemiology Network on Drug Use (SENDU) – Partnership between South Africa, Lesotho and Seychelles.

  22. LUBOMBO SPATIAL DEVELOPMENT INITIATIVEA Regional malaria control project between South Africa, Swaziland and Mozambique to create a malaria free platform for development • In July 1999 President Mbeki, President Chissano and His Majesty, King Mswati III signed the General Protocol which puts in place a platform for regional cooperation and delivery. • In October of 1999 the Lubombo Malaria Protocol and tri-national malaria programme was launched. • In December of 1999 the World Heritage Convention Act was promulgated and the Greater St Lucia Wetlands Park inscribed on the World Heritage Convention list. • In June 2000 the three countries signed the Lubombo Transfrontier Conservation and Resource Area Protocols (TFCA).

  23. HOME-BASED FOOD PRODUCTION OFPRO-VITAMIN A-RICH FOOD-ORANGE FLESHED SWEET POTATO • NIRU showed that home-based production of pro-vitamin A-rich foods, integrated with a community-based nutritional surveillance system, can alleviate vitamin A deficiency and reduce diarrhoea in preschool children significantly • A variety of orange fleshed sweet potato rich in pro-vitamin A introduced during the study proved to be easy to grow and very popular among the community • Only 50-70 g of this sweet potato can provide 100% of the recommended daily intake of vitamin A • Based on our results, NIRU was invited to participate in the Vitamin A for Africa programme which has as an objective the promotion of the production and consumption of orange fleshed sweet potato in Africa to combat vitamin A deficiency and poverty in Africa • The NIRU model will be used as a model in the 5 participating countries, ie RSA, Uganda, Tanzania, Kenya and Ethiopia

  24. Baseline Contract/Grant Economic Sustainability To achieve economical sustainability through increasing our contracts and grants income, commercialisation of intellectual assets and the implementation of innovative business models and processes BASELINE vs CONTRACT/GRANT FUNDING 2000/2001 50,000,000 45,000,000 40,000,000 35,000,000 30,000,000 RANDS 25,000,000 20,000,000 15,000,000 10,000,000 5,000,000 0 Malaria Tuberculosis HIV / SAAVI MRC UNITS

  25. Contract income MRC’s INCOME: CONTRACT RESEARCH AND EXTERNAL GRANTS - R(m) M O I L L I N 67 R 70 62 R 65 R 60 R 55 R 50 R 45 38.2 R 40 R 35 R 30 25.9 R 25 19 R 20 13.1 R 15 10.3 8.5 R 10 R 5 1994/95 1995/96 1996/97 1997/98 1998/99 1999/200 2000/2001 2001/2002 Estimate Projection

  26. Organisational Review • System Wide SETI Review 1997 • MRC SETI Review 23-27 April 2001 • Key findings: • - The MRC has made substantial progress in implementing the recommendations made in 1997. • - The MRC is a national resource and an important national asset that has made substantial progress as a centre of research excellence within the African continent and the global international community. • Future increase in the resource allocations be linked to the recommendations to enable the MRC to implement them fully. • The autonomy of the MRC should be maintained

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