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Advancing ENT Clinical Trials: UCL Research Programme

Discover the cutting-edge ENT Clinical Trials Programme led by Professor Anne Schilder at UCL - focusing on upper respiratory tract infections, allergies, hearing loss, and balance problems. The program aims to establish a world-leading initiative, bridging innovative research with patient care. Powered by the UCL Ear Institute and Clinical Biomedical Research Centre, this initiative pushes boundaries in basic science, clinical trials, and research translation. Join the effort in developing evidence-based guidelines and addressing critical gaps in ENT care.

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Advancing ENT Clinical Trials: UCL Research Programme

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  1. ENT Clinical Trials Programme Professor Anne Schilder- Director

  2. ENT- The Hidden Giant • Upper respiratory tract infections • 6 million GP consultations • most common reason for antibiotics and surgery in children • costs of antibiotics for URTI £24 million • Allergy • 3 million GP consultations • 4.5 million GP prescriptions for nasal allergies • costs of prescriptions £0.9 billion • Hearing loss • 10 million people in UK • 70% of people over 70 years • 40% experience mental health problems • costs of unemployment because of unaided hearing loss £13.5 billion • Balance problems • 14 million GP consultations • benefits claimed for dizziness £ 24 million

  3. ENT Clinical Research Activity

  4. Programme Aim • Establish the world leading ENT Clinical Trials Programme at UCL • Develop the evidence base for ENT

  5. Pathway of Translation to Practice BENCH BEDSIDE PRACTICE T1 Case studies Phase 1 and 2 Clinical Trials • Basic Science Research • Preclinical studies • Animal Research • Human Clinical Research • Controlledobservational studies • Phase 3 clinical trials • ClinicalPractice • Delivery of recommendede care to the right patient at the right time • Identification of new clinicalquestionsandgaps in care T2 TRANSLATION TO HUMANS • T2 • Guidelinedevelopment • Meta-analyses • Systematic research • T3 • Dissemination research • Implementation research • Practice-Based Research • Phase 3 and 4 clinical trials • Observational studies • Survey research TRANSLATION TO PATIENTS TRANSLATION TO PRACTICE

  6. Current Research Strengths at UCL Ear Institute Stem cell facilities UCL Clinical Biomedical Research Centre UCL Partners BENCH BEDSIDE PRACTICE T1 Case studies Phase 1 and 2 Clinical Trials • Basic Science Research • Preclinical studies • Animal Research • Human Clinical Research • Controlledobservational studies • Phase 3 clinical trials • ClinicalPractice • Delivery of recommendede care to the right patient at the right time • Identification of new clinicalquestionsandgaps in care T2 TRANSLATION TO HUMANS UCL Faculty of Population Health Sciences • T2 • Guidelinedevelopment • Meta-analyses • Systematic research • T3 • Dissemination research • Implementation research • Practice-Based Research • Phase 3 and 4 clinical trials • Observational studies • Survey research TRANSLATION TO PATIENTS TRANSLATION TO PRACTICE

  7. The Missing Link ENT Clinical Trials Programme UCL Clinical Trials Unit UCL Joint Research Office UCL Clinical Research Facility UCL Partners Ear Institute Stem cell facilities UCL Clinical Biomedical Research Centre BENCH BEDSIDE PRACTICE T1 Case studies Phase 1 and 2 Clinical Trials • Basic Science Research • Preclinical studies • Animal Research • Human Clinical Research • Controlledobservational studies • Phase 3 clinical trials • ClinicalPractice • Delivery of recommendede care to the right patient at the right time • Identification of new clinicalquestionsandgaps in care T2 TRANSLATION TO HUMANS UCL Faculty of Population Health Sciences • T2 • Guidelinedevelopment • Meta-analyses • Systematic research • T3 • Dissemination research • Implementation research • Practice-Based Research • Phase 3 and 4 clinical trials • Observational studies • Survey research TRANSLATION TO PATIENTS TRANSLATION TO PRACTICE

  8. Key Steps • Work with the Cochrane ENT Disorders group to summarise what is known about treatments and prevention of ENT conditions • Engage clinicians and form national and international collaborations spanning the translational pathway • Obtain funding, develop and open new studies and trials • Work with the UK Clinical Research Network ENT Speciality Group • Disseminate the findings and develop evidence based guidelines • Develop the next generation of research leaders in ENT

  9. Achievements so far • Joint joint Co-ordinating Editor of the Cochrane ENT Disorders Group • Chair of the National and Local Central and East London ENT Specialty Group of the NIHR Clinical Research Network • NIHR Research Professorship • ‘ New research professors will help treatments make the • leap from the bench to the bedside’ February 15, 2012

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