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Clinical Research in Yorkshire: Infrastructure & management

Clinical Research in Yorkshire: Infrastructure & management. Dr David Jackson Clinical Lead for Research YCRN Co-director WYCLRN Yorkshire Palliative Medicine Regional Learning Group April 2008. Yorkshire Cancer Research Network. Background. The NHS Cancer Plan 2000 NCRN 2001 YCRN 2002

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Clinical Research in Yorkshire: Infrastructure & management

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  1. Clinical Research in Yorkshire:Infrastructure & management Dr David Jackson Clinical Lead for Research YCRN Co-director WYCLRN Yorkshire Palliative Medicine Regional Learning Group April 2008

  2. Yorkshire Cancer Research Network

  3. Background • The NHS Cancer Plan 2000 • NCRN 2001 • YCRN 2002 “Allow conduct of clinical trials and other well designed research, to enhance the quality, speed, co-ordination of clinical research and integration with cancer care” • Best Research for Best Health 2006 • UKCRN • Comprehensive Local Research Networks • The Cancer Reform Strategy 2007

  4. Population 2.6M Yorkshire Cancer Network service Acute Trusts Cancer centre Cancer Units Unit alliances Yorkshire Cancer Research Network

  5. NCRN Portfolio “Clinical trials & other well designed studies” • Elligibility • Funding • NIHR, other government, non-commercial partners • Open competition, peer review • Clear value to the NHS • Strategic direction for research • Industry sponsored • Overseas government • Other high quality studies (e.g. EORTC) • Formal adoption process • Cancer • Prevention; screening

  6. YCRN Portfolio

  7. YCRN Functions • National portfolio • Approval processes • Local R&D • Ethics • Training & education • GCP, communication • Recruitment • Follow-up

  8. YCRN funded staff Core Team 7.6 WTE Research Team 9 WTE 1.9 WTE 1.1 WTE 2.3 WTE 0.9 WTE 1.6 WTE 2.7 WTE • Budget • £730K • YCRN staff • 26.6 WTE • Non-YCRN • 59.8 WTE

  9. YCRN funded staff • Non-surgical oncology • Haematology • Breast surgery • Genetics • Psycho-oncology • Paediatrics • Palliative care

  10. Recruitment

  11. Recruitment 15.2% 16.3% 13.8% 12.2% • Vacancy control • Patchy portfolio coverage • Slow approval processes • Service support blocks

  12. Strategic Plan • Strategic development of portfolio • Network site-specific groups • Portfolio development officers • Specialist clinical advisors • Hard-to-recruit areas • Streamline regulatory processes • Devolved teams across network • Integrated within local teams • Developing & maintaining YCRN identity • Training & Education • Service User Partnership Group • Funding • Commissioning • CLRN – service support costs

  13. West Yorkshire Comprehensive Local Research Network

  14. West Yorkshire Comprehensive Local Research Network

  15. West Yorkshire Comprehensive Local Research Network

  16. NCRNAccrual to NCRN Portfolio studies across the UK 30 25 20 15 10 Participants Recruited 5 0 Jan/Feb Mar/Apr May/Jun Jul/Aug Sep/Oct Nov/Dec Jan/Feb 05 05 05 05 05 05 06 MHRN Impact of MHRN Involvement on Study Accrual Recruitment plan updated February 2006 First recruitment recovery plan 19 September 2005 MHRN involvement in the project commenced in June 05. Comparison of recruitment into Myeloma VII (pre-NCRN) and Myeloma IX (post-NCRN) Impact of MHRN on Study Accrual The main aim of research networks: increasing recruitment into research studies West Yorkshire Comprehensive Local Research Network

  17. 25 Comprehensive Local Research Networks CLRNs

  18. N&EY & NL CLRN WY CLRN West Yorkshire Comprehensive Local Research Network

  19. Aim of UKCRN • To provide the NHS infrastructure to support clinical research across all areas of disease and clinical need • To help streamline the research management function for UKCRN portfolio studies supported by the networks To do this by: • Establishing a managed set of clinical research networks • Identifying a national portfolio of studies • Funding infrastructure (NHS support costs) for portfolio studies • Supporting the research management of these studies West Yorkshire Comprehensive Local Research Network

  20. Research Funding • ARCO 2005 • Attributing revenue costs of externally-funded non-commercial research in the NHS • Research costs • Data collection & analysis • Research funding body (NIHR, Charity) • NHS support costs • Additional tests, inpatient care • nursing support, research professionals • R&D support funding CLRN • Treatment costs • Commissioning arrangements West Yorkshire Comprehensive Local Research Network

  21. Comprehensive Local Research Networks • NIHR / UKCRN • All healthcare – primary, secondary, tertiary, MH • NHS service support costs • Infrastructure & running costs • Research staff • Research active clinicians • Research Management & Governance • Streamline across network • CSP / research passports • UKCRN portfolio • Support for Topic Clinical Research Networks • Cancer & Stroke • Primary Care Research Network Replaces Culyer funding West Yorkshire Comprehensive Local Research Network

  22. Health Research Categories West Yorkshire Comprehensive Local Research Network

  23. West Yorkshire Comprehensive Local Research Network

  24. Resources • 08/09 • Core team £413K • Clinical directors, management team • Per capita £2,250K • Activity based £1,424K • FSF £112K • Operational plan • Work in progress! • Sessional payments • RM&G infrastructure • Research infrastructure • Service support costs • “Unblocking blocks” West Yorkshire Comprehensive Local Research Network

  25. Summary • YCRN • Established & successful • Need to maintain & increase recruitment • WYCLRN • Rapid implementation & transition • Streamlined RM&G • Transparent funding streams • Strategic development of local portfolio • Strengths & weaknesses • Unblocking blocks • Local knowledge • Activity based funding

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