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Foldit

Foldit. A computer game that helps scientific research. Wei Bao 2011 11 30. Rosetta @ Home. Protein Structure prediction Protein docking Protein design. Alzheimer’s Disease Antrax Herpes simplex virus 1 HIV Malaria. Powerful, But Never Enough!!!. *From Wiki. Foldit.

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Foldit

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  1. Foldit A computer game that helps scientific research Wei Bao 2011 11 30

  2. Rosetta @ Home Protein Structure prediction Protein docking Protein design Alzheimer’s Disease Antrax Herpes simplex virus 1 HIV Malaria

  3. Powerful, But Never Enough!!! *From Wiki

  4. Foldit • In 2008, the Foldit project submitted solutions to the Critical Assessment of Techniques for Protein Structure Prediction (CASP) contest. The results were announced in early 2009. • In 2011, players of Foldithelped to decipher the crystal structure of the Mason-Pfizer monkey virus (M-PMV) retroviral protease, an AIDS-causing monkey virus. While the puzzle was available to play for a period of three weeks, players produced an accurate 3D model of the enzyme in just ten days. The problem of how to configure the structure of the enzyme had stumped scientists for 15 years.* * From Wiki Website

  5. How Does It Work • Just like playing other games.

  6. Scoring system • Hydrophobicity • Interatomic repulsion • Cavities • To get a lower energy conformation/ Rosetta energy

  7. You do not need to be professional A survey did among top 50 players

  8. Foldit Vs. Rosetta VS

  9. Beats

  10. Foldit Wins for now • Distinguish starting point • More varied methods • Motivation ( competition)

  11. Games for Christmas

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