Sébastien R. Goudreau

1. Enantioselective Carbometallation of Unactivated Olefins Sébastien R. Goudreau Literature Meeting September 16th, 2008

2. Introduction: Formation of C-C Bonds Carbonyl Chemistry Olefines Chemistry

3. Carbometallation Regioselectivity Diastereoselectivity Enantioselectivity Ziegler et al. Chem. Ber.1928, 61, 253

4. Enantioslective Carbometallation of Unactivated Olefines Zn, Cu, Mg, Al, Li Pd and Ni will not be included Marek Perkin Trans. 11999, 535

5. Zinc E. Nakamura The University of Tokyo J. F. Normant Université P. et M. Curie I. Marek Technion-Israel Institute of Technology

6. Addition of Zinc Enolate Marek, Normand et al. JOC1998, 63, 2442

7. Synthesis of Proline Derivative Marek, Normand et al. JOC1998, 63, 2442

8. Allylation of Alkene Marek, Normand et al. TL1998, 39, 4821

9. Allylation of Alkene Marek, Normand et al. TL1998, 39, 4821

10. Allylation of Alkene Marek, Normand et al. Seances Acad. Sci., Ser. II1998, 621 10

11. Allylation of Alkene Marek, Normand et al. Seances Acad. Sci., Ser. II1998, 621

12. Allylation of Alkene Marek, Normand et al. TL1998, 39, 4821 12

13. Allylation of Cyclopropene Nakamura et al. JACS1993, 115, 5867

14. Allylation of Cyclopropene Nakamura et al. JACS1993, 115, 5867

15. Allylation of Cyclopropene ent ent Nakamura et al. JACS1995, 117, 1179

16. Allylation of Cyclopropene Nakamura et al. JACS1995, 117, 1179

17. Addition on Cyclopropene: Enders’ Hydrazone Nakamura et al. JOC1997, 62, 792

18. Addition on Alkene: Enders’ Hydrazone Nakamura et al. Angew1997, 36, 2491

19. Copper E. Nakamura The University of Tokyo

20. Addition on Cyclopropene Nakamura et al. JACS1990, 112, 7428

21. Addition on Cyclopropene Nakamura et al. JACS1990, 112, 7428

22. Addition on Cyclopropene Nakamura et al. JACS1990, 112, 7428

23. Magnesium A. H. Hoveyda, Boston College

24. Addition of Grignard on Cyclopropene Fox et al. JACS2006, 128, 5600

25. Mg: Zr Catalysis ethylene-1,2-bis(η5-4,5,6,7-tetrahydro-1-indenyl)zirconium dichloride Hoveyda et al. JACS1993, 115, 6997

26. Mg: Zr Catalysis Hoveyda et al. JACS1996, 118, 4291

27. Mg: Zr Catalysis Hoveyda et al. JACS1996, 118, 4291

28. Mg: Zr Catalysis Hoveyda et al. JACS1993, 115, 6997

29. Mg: Zr Catalysis Hoveyda et al. JACS1993, 115, 6997

30. Mg: Zr Catalysis Hoveyda et al. JACS1993, 115, 6997

31. Mg: Zr Catalysis Hoveyda et al. JACS1996, 118, 4291

32. Synthesis of Sch 38516 Aglycon Macrolactam Hoveyda et al. JACS1997, 119, 10302 Hoveyda et al. JACS1995, 117, 2943

33. Synthesis of Sch 38516 Aglycon Macrolactam Hoveyda et al. JACS1997, 119, 10302 Hoveyda et al. JACS1995, 117, 2943

34. Kinetic Resolution of Pyrans Hoveyda et al. JACS1996, 118, 4291 Hoveyda et al. JACS1994, 115, 3123

35. Kinetic Resolution of Pyrans Hoveyda et al. JACS1996, 118, 4291 Hoveyda et al. JACS1994, 115, 3123

36. Kinetic Resolution of Pyrans Hoveyda et al. JACS1996, 118, 4291 Hoveyda et al. JACS1994, 115, 3123

37. Kinetic Resolution of Furans Hoveyda et al. Tetrahedron1995, 51, 4383

38. Kinetic Resolution of Furans Hoveyda et al. Tetrahedron1995, 51, 4383

39. Kinetic Resolution of Furans Hoveyda et al. Tetrahedron1995, 51, 4383

40. Kinetic Resolution of Allylic Ethers Hoveyda et al. JACS1996, 118, 3779

41. Kinetic Resolution of Allylic Ethers Hoveyda et al. JACS1996, 118, 3779

42. Synthesis of Nebivolol Hoveyda et al. JACS1998, 120, 8340

43. Synthesis of Nebivolol Hoveyda et al. JACS1998, 120, 8340

44. Synthesis of Nebivolol Hoveyda et al. JACS1998, 120, 8340

45. Addition on Alkene Whitby et al. TL1996, 39, 7139

46. Aluminium Ei-ichi Negishi Perdue University

47. Methylation of Alkene Negishi et al. JACS1995, 117, 10771

48. Methylation of Alkene Negishi et al. JACS1995, 117, 10771

49. Methylation of Alkene Negishi et al. JACS1996, 118, 1577

50. Lithium J. F. Normant Université P. et M. Curie I. Marek Technion-Israel Institute of Technology