meningiomas n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Meningiomas PowerPoint Presentation
Download Presentation
Meningiomas

Loading in 2 Seconds...

play fullscreen
1 / 3

Meningiomas - PowerPoint PPT Presentation


  • 138 Views
  • Uploaded on

Meningiomas. Usually considered benign tumors Comprise 15% of primary intracranial tumors More common in women – F:M 2:1 Highest incidence in the sixth and seventh decades Found along external surfaces of the brain and occasionally within the ventricular system

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Meningiomas' - sonya-holden


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
meningiomas
Meningiomas
  • Usually considered benign tumors
  • Comprise 15% of primary intracranial tumors
  • More common in women – F:M 2:1
  • Highest incidence in the sixth and seventh decades
  • Found along external surfaces of the brain and occasionally within the ventricular system
  • Grossly, they are well-circumscribed and firm
  • Radiologically, they exhibit homogeneous contrast enhancement on CT and MRI; calcification is common
meningiomas1
Meningiomas
  • Microscopically, the cells are relatively uniform, with round or elongated nuclei, and tend to form whorls and psammoma bodies (laminated calcific concretions)
  • Most frequent genetic defect – mutations in the neurofibromatosis 2 gene (merlin) on chromosome 22q
  • Some meningiomas contain estrogen and progesterone receptors
  • Ultrastructurally, they form complex interdigitations between cells
meningioma subtypes
Meningioma Subtypes
  • Syncytial - whorled clusters of cells in tight groups
  • Fibroblastic – elongated cells and abundant collagen deposition
  • Transitional – features of syncytial and fibroblastic types
  • Psammomatous – numerous psammoma bodies
  • Secretory – PAS + intracytoplasmic droplets and intracellular lumens by electron microscopy
  • Microcystic – loose, spongy appearance

Most are considered grade I/IV by the WHO, with a relatively low risk of recurrence; the various histologic appearances carry no prognostic significance