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Zinc Fingers. By Jeffrey Mah Biotechnology 2009-2010. Definition:. A type of small protein with 20-30 amino acids Bonded to a zinc ion Play essential roles in DNA recognition. Found in:. Thousands of other proteins Plants Animals BUT not bacteria . Function/Regulation:.

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zinc fingers
Zinc Fingers

By Jeffrey Mah

Biotechnology 2009-2010

definition
Definition:
  • A type of small protein with 20-30 amino acids
  • Bonded to a zinc ion
  • Play essential roles
  • in DNA recognition
found in
Found in:
  • Thousands of other proteins
  • Plants
  • Animals
  • BUT not bacteria
function regulation
Function/Regulation:
  • The expression of genes
  • Assembly of viruses
  • Reverse transcription
  • Nucleic acid recognition
  • Stabilizes and solidifies DNA and RNA
structure
Structure:
  • Main structure:
    • 1 tetrahedron
    • - 2 Cysteines
    • - 2 Histidines
    • - 1 zinc ion
structure1
Structure:

The other 15-25 amino acids all face more-or-less outwards, and can be used for various functional tasks

significance
Significance:
  • Tiny protein that helps with DNA related work
  • Researchers are currently trying to design artificial zinc fingers with different specificities
work cited
Work Cited
  • http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html
  • http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_2.html
  • http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_3.html
  • http://upload.wikimedia.org/wikipedia/commons/7/79/Zinc_finger_DNA_complex.png
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